Excitatory Adrenergic Receptors in the Human Stomach and Pylorus

Haffner, J. F. W.; Liavåg, I; Setekleiv, J.

doi:10.3109/00365526909179922

Cited by 19 publications

(17 citation statements)

References 9 publications

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“…benzamine failed to block the action of adrenaline(10-7-10-6g/ml),noradrenaline (10-6g/ml)and isoprenaline(10-6g/ml).However,adrenaline 10-5g/ml slightly increased the spike activity. Figure 7(C-F)shows the effects of noradrenaline and adrenaline in the presence of phenoxybenzamine(10-5g/ml).Similar results wre obtained in the fundus preparations which were immersed in TEA (10-20mM and DANIEL,1968;MUNRO,1951;REYNOLDS et al,1967) and stomach (COMLINE and TITCHEN,1951;DUNCAN,1954;OFFERMEIER,1965;SANFORD,1968;TITCHEN and NEWHOOK,1968; VAN MIERT and HUISMAN,1968;GUIMARAES,1969;INNES and KOHLI,1969;HAFFNER,et al,1969;BAILEY,1971 preparations in the normal state.This excitatory action of phenylephrine was also observed in the presence of propranolol or DCI.In the mechanical activity, it has been reported that the excitatory response to phenylephrine was potentiated by propranolol and sotalol (BAILEY,1971).The obtained results seem to confirm with the above findings in mechanical response. On the other hand,the effect of phenylephrine on the antrum and fundus preparations was completely antagonized by phentolamine or phenoxybenzamine.These results suggest that the excitatory action of catecholamines on the electrical activity of the smooth muscle of stomach may be mediated by alpha-adrenoceptors.…”

Section: Effects Of Catecholamines In the Presence Of Propranololsupporting

confidence: 64%

Evidences for Alpha Excitatory Action of Catecholamines on the Electrical Activity of the Guinea-Pig Stomach

Ohkawa

1976

Jpn.J.Physiol

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Effects of catecholamines and their inhibitors on the electrical activity of the smooth muscle of the guinea-pig stomach were studied by using pressure electrodes.The spontaneous electrical activity of antrum and corpus preparations consisted of slow waves with or without superimposed spikes.In quiescent fundus preparations,the spike activity and slow waves were generated by TEA.Catecholamines(noradrenaline, isoprenaline and adrenaline)suppressed or blocked the spike discharges and the generation of slow waves.However,the spike activity was enhanced at a higher concentration of phenylephrine in the antrum and fundus preparations.Inhibitory responses of the smooth muscles from whole regions to adrenaline,noradrenaline or isoprenaline were antagonized by propranolol or DCI but not by phentolamine or phenoxybenzamine.Therefore,inhibitory actions of these amines appear to involve beta-adrenoceptors.After treatment with tetrodotoxin,noradrenaline and isoprenaline blocked the spike activity and the generation of slow waves.Phenylephrine or adrenaline potentiated the spike activity in the presence of tetrodotoxin.After treatment with DCI or propranolol,phenylephrine potentiated the spike activity of the antrum and fundus preparations.These excitatory effects were antagonized by phentolamine or phenoxybenzamine.It is concluded that excitatory actions of these amines are mediated by alpha-adrenoceptors rather than via a nervous pathway.

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Section: Effects Of Catecholamines In the Presence Of Propranololsupporting

confidence: 64%

Evidences for Alpha Excitatory Action of Catecholamines on the Electrical Activity of the Guinea-Pig Stomach

Ohkawa

1976

Jpn.J.Physiol

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“…Similar responses have been recorded from the stomach of the guinea-pig, rat, rabbit and dog (Smith, 1918;McSwiney & Brown, 1926;Lange, 1955;Offermeier, 1966;Ehrreich & Furchgott, 1968;Guimaraes, 1969;Innes & Kohli, 1969); from human stomach (Haffner, Liavag & Setekleiv, 1969) and from ruminant stomach (Duncan, 1954;Sanford, 1968;Titchen, 1968 ; Van Miert & Huisman, 1968). Oesophageal smooth muscle from the cat also contracts in response to sympathomimetic amines (Christensen & Daniel, 1966.…”

Section: Introductionmentioning

confidence: 54%

Inhibitory and excitatory effects of sympathomimetic amines on muscle strips from the stomach of the guinea‐pig

Bailey

1971

British J Pharmacology

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Summay1. Responses of muscle strips from the stomach of the guinea-pig have been recorded. Sympathomimetic amines cause inhibitory, motor or biphasic responses.2. The motor components of the responses of the preparations were greatly enhanced by the removal of the mucosal layers.3. The inhibitory responses to isoprenaline, noradrenaline and phenylephrine were antagonized by propranolol or by sotalol. The inhibitory responses to noradrenaline and phenylephrine but not isoprenaline were antagonized by phentolamine. Therefore, both a-and f3-adrenoceptors may subserve inhibition. 4. The motor responses to noradrenaline and phenylephrine were often potentiated by propranolol or sotalol and were antagonized by phentolamine. Therefore, motor responses to sympathomimetic amines appear to involve a-adrenoceptors. 5. The responses to sympathomimetic amines and their antagonists were not modified by hyoscine or by tetrodotoxin. It is concluded that the adrenoceptors mediating the responses recorded from these preparations are located on the smooth muscle cells rather than on a nervous pathway.

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“…When catecholamine concentrations are lower than 10-6 g/ml, contraction is more frequently observed in both circular and longitudinal muscles, as observed in the human stomach (9) and in the rabbit stomach (8). Therefore, the proportion of responses me diated through the a and 8-receptors varies with the concentration of catecholamines.…”

Section: Changes In Tension By Catecholaminesmentioning

confidence: 94%

“…On the other hand, in isolated human stomach muscle, the inhibitory effect is mediated only through the a-receptor (7,9).…”

mentioning

confidence: 99%

Mechanical Responses to Catecholamines in Isolated Strips of the Guinea-Pig Stomach Muscle

Yamaguchi

Tomita

1974

Japanese Journal of Pharmacology

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Excitatory Adrenergic Receptors in the Human Stomach and Pylorus

Cited by 19 publications

References 9 publications

Evidences for Alpha Excitatory Action of Catecholamines on the Electrical Activity of the Guinea-Pig Stomach

Evidences for Alpha Excitatory Action of Catecholamines on the Electrical Activity of the Guinea-Pig Stomach

Inhibitory and excitatory effects of sympathomimetic amines on muscle strips from the stomach of the guinea‐pig

Mechanical Responses to Catecholamines in Isolated Strips of the Guinea-Pig Stomach Muscle

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