Excitatory, Inhibitory and Peptidergic Pathways in the Mudpuppy Retina

Miller, Robert F.; Slaughter, Malcolm M.; Dick, Evan

doi:10.1007/978-1-4684-1140-9_47

Cited by 16 publications

(8 citation statements)

References 23 publications

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“…Both aspartate and glutamate are neurotransmitter candidates in the plexiform layers (Altschuler et al 1982, Miller et al 1982, Mitchell & Redburn 1982.…”

Section: Discussionmentioning

confidence: 99%

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The release of (³H)‐GABA from the rabbit retina

Agardh

Bauer

1984

Acta Physiologica Scandinavica

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The neuronal and glial release of (3H)-GABA from rabbit retina has been studied. The results indicate, that neither are there any glutamate, aspartate or glycine receptors on the GABA accumulating neurons, nor any GABA autoreceptors. (3H)-GABA was found to be released by 40 mM K+ from retinal neurons, but not from glia, and the release was not dependent on extracellular Ca++. This indicates a release from a non vesicular transmitter pool. Ouabain has been proposed as a pharmacological tool for studying the release of (3H)-GABA located in neuronal cytoplasm. However, it induced an increased release of (3H)-GABA from both neurons and glia and it is therefore unlikely that it can be used for the specific purpose of studying release from neuronal cytoplasm.

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“…Both aspartate and glutamate are neurotransmitter candidates in the plexiform layers (Altschuler et al 1982, Miller et al 1982, Mitchell & Redburn 1982.…”

Section: Discussionmentioning

confidence: 99%

“…Glutamate and aspartate are likely excitatory transmitters in the central nervous system (Watkins & Evans 1981), and are also good candidates as transmitters in at least some parts of the retina (Miller et al 1982). GABA and glycine are likely to be neurotransmitters in certain amacrine cells (Ehinger 1982).…”

mentioning

confidence: 99%

The release of (³H)‐GABA from the rabbit retina

Agardh

Bauer

1984

Acta Physiologica Scandinavica

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“…In nonmammalian retina some authors have found that GABA diminishes the light responses of ON bipolar cells without changing their resting membrane potential ( mudpuppy : [177, 205]). The effects of GABA persist after blockade of synaptic transmission with cobalt + and are blocked by bicuculline and picrotoxin, indicating that they are due to direct action of GABA on ionotropic GABA receptors expressed on the ON bipolar cells.…”

Section: Effects Of Gaba On Bipolar Cellsmentioning

confidence: 99%

Ionotropic GABA Receptors and Distal Retinal ON and OFF Responses

Popova

2014

Scientifica

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In the vertebrate retina, visual signals are segregated into parallel ON and OFF pathways, which provide information for light increments and decrements. The segregation is first evident at the level of the ON and OFF bipolar cells in distal retina. The activity of large populations of ON and OFF bipolar cells is reflected in the b- and d-waves of the diffuse electroretinogram (ERG). The role of gamma-aminobutyric acid (GABA), acting through ionotropic GABA receptors in shaping the ON and OFF responses in distal retina, is a matter of debate. This review summarized current knowledge about the types of the GABAergic neurons and ionotropic GABA receptors in the retina as well as the effects of GABA and specific GABAA and GABAC receptor antagonists on the activity of the ON and OFF bipolar cells in both nonmammalian and mammalian retina. Special emphasis is put on the effects on b- and d-waves of the ERG as a useful tool for assessment of the overall function of distal retinal ON and OFF channels. The role of GABAergic system in establishing the ON-OFF asymmetry concerning the time course and absolute and relative sensitivity of the ERG responses under different conditions of light adaptation in amphibian retina is also discussed.

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“…3 3 , and adenylokinase (EC 2.7.4.3). The mudpuppy retina is of particular interest because extraordinarily little is known about energy metabolism in this structure, which has been the focus of very many studies of central nervous system function at the cellular level (for a recent review see Miller et al, 1982).…”

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confidence: 99%

Enzymes of Energy Metabolism in the Mudpuppy Retina

Dick

1984

Journal of Neurochemistry

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The distributions of glycogen phosphorylase, hexokinase, phosphofructokinase, lactate dehydrogenase, glucose-6-phosphate dehydrogenase, citrate synthase, malate dehydrogenase, beta-hydroxyacyl CoA dehydrogenase, and adenylokinase were determined in the mudpuppy retina. Distinct differences were found in regard to the glycolytic and oxidative capacities of the various layers. In the outer retina, citric acid cycle enzymes were high while glycolytic enzymes were low. Synaptic zones were distinctly enriched in all energy-producing enzymes. Mudpuppy photoreceptors were found to be rich in phosphorylase but poor in glucose-6-phosphate dehydrogenase, suggestive of some evolutionary divergence from mammals in the metabolic machinery which is used to support the visual process.

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Excitatory, Inhibitory and Peptidergic Pathways in the Mudpuppy Retina

Cited by 16 publications

References 23 publications

The release of (³H)‐GABA from the rabbit retina

The release of (³H)‐GABA from the rabbit retina

Ionotropic GABA Receptors and Distal Retinal ON and OFF Responses

Enzymes of Energy Metabolism in the Mudpuppy Retina

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Excitatory, Inhibitory and Peptidergic Pathways in the Mudpuppy Retina

Cited by 16 publications

References 23 publications

The release of (3H)‐GABA from the rabbit retina

The release of (3H)‐GABA from the rabbit retina

Ionotropic GABA Receptors and Distal Retinal ON and OFF Responses

Enzymes of Energy Metabolism in the Mudpuppy Retina

Contact Info

Product

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The release of (³H)‐GABA from the rabbit retina

The release of (³H)‐GABA from the rabbit retina