Exclusive facial porokeratosis: Histopathologically showing follicular cornoid lamellae

Lee, Yoon-Hee; Choi, Eung Ho

doi:10.1111/j.1346-8138.2011.01260.x

Cited by 19 publications

(23 citation statements)

References 24 publications

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“…6 Other forms show punctate lesions that demonstrate the same cornoid lamellae. 4 Systemic immunosuppression, whether iatrogenic or secondary to malignancy, may increase the risk of developing DSAP and PM. It is believed that a genetic predisposition induces a clonal proliferation of abnormal keratinocytes.…”

Section: Discussionmentioning

confidence: 99%

“…An autosomal dominant inheritance pattern with incomplete penetrance is most commonly reported. [1][2][3][4][5] In these cases, the abnormal clonal proliferation of keratinocytes that spreads radially to form the cornoid lamella penetrates the "innocent bystander" hair follicles. 8,9 Other pathophysiologic factors may also be important.…”

Section: Discussionmentioning

confidence: 99%

“…7 Chromosome 18p11.3 has been linked to several subtypes of porokeratosis, and chromosome 12q24.1 has been linked to both DSAP and porokeratosis palmaris et plantaris disseminata. 4 Punctate follicular porokeratosis was previously described in a middle-aged man with multiple static perifollicular papules on the upper arms that had been present for many years. A predilection for sun-exposed skin suggests that ultraviolet radiation exposure plays a role in the induction of DSAP.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] An additional case reported punctate porokeratosis emanating from a hair follicle with no associated annular cornoid lamella. A number of clinical variants have been identified, including porokeratosis of Mibelli (PM), disseminated superficial actinic porokeratosis (DSAP), linear porokeratosis, porokeratosis palmaris et plantaris disseminata, and punctate porokeratosis.…”

Section: Introductionmentioning

confidence: 99%

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Punctate Follicular Porokeratosis

Trikha

Wile²,

King

et al. 2015

The American Journal of Dermatopathology

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Porokeratosis is a disorder of keratinization characterized by an abnormal cornoid lamella surrounding an annular, scaly plaque with an atrophic center. A histologic variant of this condition has been proposed, termed follicular porokeratosis, in cases where follicular involvement was contiguous with an annular cornoid lamella. There has been only 1 report of punctate follicular porokeratosis, in which cornoid lamellae originated exclusively from hair follicles with no associated annular plaque. The authors present the second case of punctate follicular porokeratosis, further supporting the contention that this entity is a unique form of porokeratosis rather than a histologic variant. A 56-year-old African American female presented to the dermatology clinic with a 3-month history of keratotic lesions localized on the right posterior shoulder. Examination revealed an area of perifollicular keratotic papules, each surrounded by an erythematous rim. Histopathology revealed a cornoid lamella originating within a hair follicle, with the parakeratotic column protruding through the follicular orifice. The static nature of the condition along with exclusive involvement of hair follicles supports the notion of punctate follicular porokeratosis as a distinct clinical entity. The diagnosis of this condition relies heavily on proper histopathologic sampling revealing punctate follicular cornoid lamellae.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Punctate Follicular Porokeratosis

Trikha

Wile²,

King

et al. 2015

The American Journal of Dermatopathology

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“…Pathologists having knowledge of this new histopathologic entity will help dermatologists in identifying new cases of follicular porokeratosis. [17]…”

Section: Discuscionmentioning

confidence: 99%

Follicular porokeratosis at alae nasi; A case report and short review of literature

Rifaioğlu

Özyalvaçlı

2014

Indian J Dermatol

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Porokeratosis are disorders of keratinization, characterized histologically by a parakeratotic column, the cornoid lamellae, and clinically by a distinct peripheral ridge. Porokeratosis usually occurs on the trunk or extremities, and facial lesions are rare. Follicular involvement, identified by follicular localization of cornoid lamellae, is uncommon and described only in association with disseminated superficial actinic porokeratosis (DSAP) and porokeratosis Mibelli (PM). A 34-Year- old woman is presented with asymptomatic 1 cm plaque lesion with hyperkeratotic ridge and depressed center on her nose since three years. Histopathological examination of a biopsy revealed cornoid lamellae confined exclusively to the follicle.

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Long-term Clearance of Linear Porokeratosis With Tacrolimus, 0.1%, Ointment

2014

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Porokeratosis is a disorder of abnormal keratinization with multiple clinical variants. It is often difficult to achieve complete resolution of porokeratosis even with a variety of therapies that have been reported to have some efficacy. Report of a CaseA woman in her 40s with no significant medical history was referred for evaluation of a painful dermatitis on her left arm. Approximately 1 year earlier, a painful, pruritic, erythematous papule had developed on her left arm, which subsequently spread into a linear array of papules extending from her left wrist up her arm to her neck, associated with pruritus, paresthesias, and pain; 3-to 10-mm erythematous papules with overlying scales were arranged in a linear pattern extending up the ventral part of her arm, across her shoulder to the left side of her neck and chest ( Figure 1). Several lesions exhibited an outer hyperkeratotic rim. She had similarly shaped areas of hyperpigmentation without overlying epidermal change on her left arm and on the left side of her chest and neck.A skin biopsy sample revealed a vertical column of parakeratosis within the stratum corneum, an absent granular layer underlying the column, and a focal lymphohistiocytic infiltrate underlying the epidermal change. The clinical and histopathologic features confirmed a diagnosis of linear porokeratosis. The patient had been treated with betamethasone dipropionate, 0.05%, ointment for several months with minimal improvement; oral acitretin treatment was subsequently started at 25 mg/d. After 3 months of acitretin treatment, she had no improvement of the lesions on her arm but had adverse effects, including scaling of her palms and soles and dryness of her lips and face.We continued daily treatment with betamethasone dipropionate, 0.05%, ointment and added tacrolimus, 0.1%, ointment, administered twice daily, to the patient's treatment regimen. Oral acitretin treatment was discontinued because it had caused adverse effects with no skin improvement. With the combination of betamethasone and tacrolimus, the skin lesions improved rapidly and dramatically. At the 2-month follow-up examination, the patient had hyperpigmented macules and patches in a linear pattern up the ventral side of her left arm and across the shoulder to her neck on the left side, consistent with postinflammatory hyperpigmentation. The inflammation had completely cleared. In addition to improved skin lesions, the patient reported complete resolution of associated pain, pruritus, and paresthesia.The patient was followed up at 3-to 6-month intervals for 2½ years, during which her skin showed continued improvement. Tacrolimus treatment was tapered down to once-daily administration to areas of postinflammatory hyperpigmentation and any new lesions, with betamethasone used only on new lesions. At 2½-year follow-up, the daily tacrolimus treatment was discontinued. At examination, the patient's skin was essentially back to baseline, with only a few very faint reticulated pale-brown macules (Figure 2), thus demonstrating the long-ter...

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Exclusive facial porokeratosis: Histopathologically showing follicular cornoid lamellae

Cited by 19 publications

References 24 publications

Punctate Follicular Porokeratosis

Punctate Follicular Porokeratosis

Follicular porokeratosis at alae nasi; A case report and short review of literature

Long-term Clearance of Linear Porokeratosis With Tacrolimus, 0.1%, Ointment

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