Exclusive Primary Lesion of Oral Leishmaniasis with Immunohistochemical Diagnosis

Almeida, Tatiana Fernandes Araújo; Silveira, Esmeralda Maria Da; Santos, Cássio Roberto Rocha dos; León, Jorge Esquiche; Mesquita, Ana Terezinha Marques

doi:10.1007/s12105-016-0732-7

Cited by 26 publications

(19 citation statements)

References 18 publications

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“…Paragraph 4: there is no reasonable evidence suggesting MCL is generally associated with VL or immunosuppression. All references supporting this statement (11)(12)(13)(14)(15)(16)(17)(18)(19) are case reports informing unusual clinical presentations. It's highly recommended to authors review https://doi.org/10.1016/B978-0-323-55512-8.00104-6 for a better understanding of the pathobiology and risk factors of MCL.…”

Section: Data Availabilitymentioning

confidence: 86%

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Orofacial manifestations of mucocutaneous leishmaniasis: a case series from Brazil

et al. 2020

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Dentists play a fundamental role in the early diagnosis of oral leishmaniasis. Although these lesions are rare at oral mucosa, this is one of the manifestations sites of the disease This study reports seven clinical cases of orofacial mucocutaneous leishmaniasis. All had leishmaniasis diagnosis confirmed by laboratory tests, with orofacial involvement. Five out of the seven cases were males, and in four cases, patients had associated comorbidities. Late diagnosis was observed, resulting in treatment delay and increased hospitalization stay. One patient had severe psychological consequences due to facial deformity. The lack of differential diagnosis due the great variability of clinical presentation of the lesions and frequent unspecific histopathology represent a challenge for the dentist. In two reported cases, there were unspecific biopsy results. This series of cases highlights the importance of a multidisciplinary approach in the diagnosis and treatment of oral and perioral leishmaniasis. Patients with atypical lesions, originating from or living in endemic regions, should be investigated for leishmaniasis. These procedures could avoid delays in diagnosis and decrease the risk of disease dissemination.

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Section: Data Availabilitymentioning

confidence: 86%

“…Facial involvement of leishmaniasis is a serious complication, since it can lead to disfiguration and be potentially fatal 11,12 . In one case reported, the patient had severe psychological consequences due to facial deformity, reinforcing the importance of early diagnosis and appropriate therapy.…”

Section: Discussionmentioning

confidence: 99%

Orofacial manifestations of mucocutaneous leishmaniasis: a case series from Brazil

et al. 2020

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“…According to Almeida, most mucosal leishmaniasis occur in the tongue (35.0%), followed by the palate (20.0%) and the buccal mucosa (10.0%). In four cases (20.0%), multiple lesions involving different sites on the oral mucosa were observed.…”

Section: Discussionmentioning

confidence: 99%

Case report: Leishmaniasis in the tongue presenting as an SCC

Chapman

Patel

2018

Oral Surgery

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A 72-year-old immunocompetent male with a frequent travel history to Spain presented with a 1 cm diameter ulcer with rolled edges on the left lateral border of the tongue. This was urgently biopsied as a squamous cell carcinoma (SCC) was suspected. Histopathology suggested a Leishmania infection which was confirmed by positive results for Leishmania DAT and K39 tests. This resulted in a diagnosis of mucocutaneous leishmaniasis. This was successfully treated by amphotericin B. Leishmaniasis solely affecting the oral mucosa is rare with few cases documented in literature. Clinical relevanceLeishmaniasis is a tropical disease which can appear in the mouth as ulcers which can resemble SCC's.This overview of leishmaniasis describes the disease, its appearance and the treatment with a case report for description to advise clinicians on the management of this relatively unknown disease.Oral Surgery 12 (2019) 159--162. Figure 1 Showing the 1 cm diameter ulcer on the lateral border of the tongue. Oral Surgery 12 (2019) 159--162.

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“…Leishmaniasis Mucosa (LM) is a chronic infection that affects the upper respiratory tract and/or oral mucosa. The etiological agents Leishmania brazilienses , followed by L. panamensis and L. amazonenses are the main causers of LM [ [1] , [2] , [3] ].…”

Section: Introductionmentioning

confidence: 99%

“…In general, it presents as erythema and ulceration or as exophytic plaque, papules and/or nodules, usually affecting hard palate, soft palate and tongue. However, they can affect any site such as the lip, uvula, gingiva, amygdala and retromolar region, associated with pain, edema, foul smell, bleeding and sialorrhea [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Parasitological association between human leishmaniosis mucosa and paracoccidioidomycosis. Case report

Gonçalves¹,

Carneiro²,

Cruz

et al. 2020

International Journal of Surgery Case Reports

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Highlights It affects the upper part of the aerodigestive tract, with mainly lesions in the oral and nasal mucosa and occasionally in the larynx and pharynx. The exclusive involvement of oral mucosa is quite rare. The diagnosis of leishmaniasis is a real challenge for all professional team. In Brazil, the highest incidence of Leishmaniasis is in the Northern Region, which comprises the States of Acre, Amapá, Amazonas, Pará, Rondônia, Roraima and Tocantins. Coexistence of parasitic diseases between Paracoccidioidomycosis and Leishmaniasis.

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Exclusive Primary Lesion of Oral Leishmaniasis with Immunohistochemical Diagnosis

Cited by 26 publications

References 18 publications

Orofacial manifestations of mucocutaneous leishmaniasis: a case series from Brazil

Orofacial manifestations of mucocutaneous leishmaniasis: a case series from Brazil

Case report: Leishmaniasis in the tongue presenting as an SCC

Parasitological association between human leishmaniosis mucosa and paracoccidioidomycosis. Case report

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