Orofacial manifestations of mucocutaneous leishmaniasis: a case series from Brazil

Falcão, Gleicy Gabriela Vitória Spinola Carneiro; Lins-Kusterer, Liliane; Ribeiro, Patrícia Miranda Leite; Sarmento, Viviane Almeida

doi:10.12688/f1000research.19056.4

Cited by 11 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only one patient tested positive for HIV and only two were women [6]. Falcão et al [7] reported seven new cases involving the oral cavity in Brazil. Of these cases, ve were men, one was HIV-positive, and most had ulcerated lesions on the lips.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Oral Leishmaniasis in HIV-Positive and HIV-Negative Patients: A Comparative Analysis with Two New Case Reports

Rosa,

de Senna,

Passador-Santos

et al. 2024

Preprint

View full text Add to dashboard Cite

Purpose This case report examines the clinical presentation, diagnosis, treatment, and outcomes of mucocutaneous leishmaniasis with primary oral involvement in HIV-positive and HIV-negative patients diagnosed in Brazil. Methods We discuss the clinical manifestations, diagnostic methods, and therapeutic strategies, highlighting the clinical and histopathologic diagnostic features and distinct progression patterns based on HIV status. Our findings are compared with patterns observed in other countries, emphasizing the differences between the New World and Old World. Results In the New World, particularly in Brazil, mucocutaneous leishmaniasis often presents with localized oral lesions, even in the presence of systemic immunosuppression, whereas in the Old World, oral involvement is typically associated with visceral leishmaniasis in immunocompromised patients. These differences were due to variations in the parasite species involved. Conclusion This comparison underscores the importance of regional and immunological factors in the diagnosis and management of this neglected infectious disease.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Therefore, in the New World, oral leishmaniasis is considered a mucocutaneous manifestation of tegumentary leishmaniasis, and is not typically recognized as the primary site of infection. However, cases of mucosal leishmaniasis with primary oral involvement, including isolated lesions on the oral mucosa, have been reported [6,7].…”

Section: Introductionmentioning

confidence: 99%

Oral Leishmaniasis in HIV-Positive and HIV-Negative Patients: A Comparative Analysis with Two New Case Reports

Rosa,

de Senna,

Passador-Santos

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…After the removal of duplicates, 4377 reports were retrieved through the searches in different databases. Of these, 10 were included that reported on a total of 192 ML patients [5,6,16,[34][35][36][37][38][39][40]. 160 full texts were excluded because they reported on less than five ML patients and seven because they presented no data at the individual patient level.…”

Section: Study Selection and Data Obtainedmentioning

confidence: 99%

Clinical criteria for Mucosal Leishmaniasis diagnosis in rural South America: A systematic literature review

et al. 2022

View full text Add to dashboard Cite

Background Mucosal Leishmaniasis (ML), a neglected tropical disease caused by Leishmania parasites, impairs the quality of life of under-resourced populations in South America. If not treated promptly, this disease progresses to facial deformities and death. The low sensitivity of microscopy results and the unavailability of other accurate tests hamper the diagnosis. As clinical criteria are readily available in any setting, these may be combined in a syndromic algorithm, which in turn can be used as a diagnostic tool. We explore potential clinical criteria for a syndromic diagnostic algorithm for ML in rural healthcare settings in South America. Methodology/Principal findings The protocol for this systematic review was pre-registered in PROSPERO with the number: CRD42017074148. In patients with ML, described in case series identified through a systematic retrieval process, we explored the cumulative ML detection rates of clinical criteria. Participants: all patients with active mucosal disease from an endemic area in South America. Any original, non-treatment study was eligible, and case reports were excluded. PUBMED, EMBASE, Web of Science, SCIELO, and LILACS databases were searched without restrictions. The risk of bias was assessed with the JBI checklist for case series. We included 10 full texts describing 192 ML patients. Male gender had the highest detection rate (88%), followed by ulcer of the nasal mucosa (77%), age >15 (69%), and symptom duration >4 months (63%). Significance Within this selection of patients, we found that the male gender, ulcer of the nasal mucosa, age >15, and symptom duration >4 months lead to the highest detection rates. However, higher detection comes -naturally- with a higher rate of false positives as well. As we only included ML patients, this could not be verified. Therefore, the criteria that we found to be most promising should be validated in a well-designed prospective study.

show abstract

“…Respiratory tract invasion and secondary bacterial infection might lead to patient's demise. Being a potentially life-threatening disease, it requires immediate and early diagnosis, treatment and sometimes seen in immunocompromised individuals (Falcao et al, 2020). It is usually found in Latin America, caused by Leishmania braziliensis, Leishmania panamensis and Leishmania guyanensis (Sachdeva and Sharma, 2016).…”

Section: Mucocutaneous Leishmaniasismentioning

confidence: 99%

Overview on Epidemiology of Leishmaniasis in Iraq

Al-Hayali¹,

alkattan²

2021

RJS

View full text Add to dashboard Cite

Leishmaniasis continues to be a significant public health issue and socioeconomic obstacle in Iraq. The various species of leishmania are transmitted by the bite of sandflies belonging to genus phlebtomus, where high temperatures might prolong the breeding season for this fly species. The current review proved that the infection in the southern regions of Iraq is more than in the northern regions. The incidence of leishmaniasis has increased and expanded to most Iraqi governorates, the reason may be due to the population growth, urbanization, pronounced poverty and lack of public health awareness. Furthermore, leishmaniasis is a zoonotic disease with a rodent, cats and dog's reservoir that poses a problem to human health. Leishmaniasis has spread in Iraq from the 1950s until now, additionally, wars forced migration of Iraqi people from their province to other places. All these have encouraged an increase in the infected rate with leishmaniasis in areas previously uninfected.

show abstract

Orofacial manifestations of mucocutaneous leishmaniasis: a case series from Brazil

Cited by 11 publications

References 25 publications

Oral Leishmaniasis in HIV-Positive and HIV-Negative Patients: A Comparative Analysis with Two New Case Reports

Oral Leishmaniasis in HIV-Positive and HIV-Negative Patients: A Comparative Analysis with Two New Case Reports

Clinical criteria for Mucosal Leishmaniasis diagnosis in rural South America: A systematic literature review

Overview on Epidemiology of Leishmaniasis in Iraq

Contact Info

Product

Resources

About