1966
DOI: 10.1136/jnnp.29.1.85
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Excretion of 5-hydroxyindolyl acetic acid (5HIAA) in migraine.

Abstract: During the prodromal phase of a migraine attack, vasoconstriction occurs which is followed during headache by the dilatation of cranial blood vessels (Marcussen and Wolff, 1950). Therefore, the metabolism in migraine of physiologically occurring vasoactive substances such as 5-hydroxytryptamine (5HT) and the catecholamines is of interest. A further indication of the possible importance of 5HT is that ergot alkaloids, such as methysergide, used in the treatment of migraine are pharmacological antagonists of thi… Show more

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Cited by 54 publications
(20 citation statements)
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“…This strengthens the hypothesis of a link between 5-HT metabolism and migraine in the pathogenesis of migraine attacks (18)(19)(20)(21). This strengthens the hypothesis of a link between 5-HT metabolism and migraine in the pathogenesis of migraine attacks (18)(19)(20)(21).…”
Section: Resultssupporting
confidence: 84%
“…This strengthens the hypothesis of a link between 5-HT metabolism and migraine in the pathogenesis of migraine attacks (18)(19)(20)(21). This strengthens the hypothesis of a link between 5-HT metabolism and migraine in the pathogenesis of migraine attacks (18)(19)(20)(21).…”
Section: Resultssupporting
confidence: 84%
“…[6][7][8][9][10][11][12][13] Recent studies have also implicated indolalkylamines and catecholamines in the central nervous system in sleep mechanisms. [6][7][8][9][10][11][12][13] Recent studies have also implicated indolalkylamines and catecholamines in the central nervous system in sleep mechanisms.…”
Section: The Relationship Between Stages Of Sleep and Circulatory Sermentioning
confidence: 99%
“…This observation was confirmed by Curran et al (1965) in 16 out of 31 migraine attacks studied, whilst another group of workers found this correlation to exist in only 2 out of 9 patients similarly investigated (Curzon et al, 1966). The role of serotonin in migraine was further emphasised by the success of the serotonin antagonist methysergide in the treatment of the disorder.…”
Section: Serotoninmentioning
confidence: 70%