Excretion of urea by the rat kidney in isotonic saline diuresis: a micropuncture study

Roch-Ramel, F; Churchill-Borloz, M; Carmignac, Daniele; Michoud, P; Peters, G.

doi:10.1152/ajplegacy.1972.222.2.489

Cited by 4 publications

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“…The urine flow rate, which is markedly affected by saline loading [3,7-9.13,16], has a well-estab lished effect on urea clearance over the range of flow rates under consideration [10,12]. Thus, the failure of the BUN to rise after glycerol administration when a high urine flow rate is maintained by saline drinking may not indicate protection from acute renal failure, but rather the effect of the saline diuresis on the urea clearance and BUN con centration.…”

Section: Discussionmentioning

confidence: 99%

“…The conclusions were mainly based on blood urea nitro gen (BUN) determinations. The use of this indirect meas ure of GFR appears suboptimal on theoretical grounds considering that tissue damage accompanies the glycerol model of acute renal failure [I I], and that the saline diuresis associated with saline loading would be expected to alter urea clearance independent of the GFR [10,12]. More over, the reported protective effect of saline does not alter the renal morphologic changes that characterize glycerolinduced renal failure [8], We therefore reexamined the protective effects of saline loading on the glycerol model of acute renal failure using standard renal inulin clearance techniques to measure GFR.…”

Section: Introductionmentioning

confidence: 99%

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Lack of an Effect of Saline Loading on Glycerol-Induced Acute Renal Failure

Cabili¹,

Charney²

1982

Nephron

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To determine whether saline loading actually protects against acute renal failure, both Gn and BUN were measured in rats drinking either tap water or 1% saline for 1–3 months. At 24 and 48 h after an injection of 10 ml/kg i.m. of 50% glycerol in water, Gn was equally reduced in saline-drinking and water-drinking rats as compared to uninjected rats. The daily intraperitoneal injection of saline for 1–3 months also was not protective. At 48 hours after glycerol injection, the BUN concentration in saline-drinking rats was significantly lower than in water-drinking rats. This was probably due to the greater renal urea clearance in these animals. We conclude from these findings that saline loading does not protect against glycerol-induced acute renal failure in the rat although it affects the C_urea and BUN concentration.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lack of an Effect of Saline Loading on Glycerol-Induced Acute Renal Failure

Cabili¹,

Charney²

1982

Nephron

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“…Body weight averaged 218 ± 6 g. By previously described methods, polyethylene catheters were inserted in a carotid artery (for blood sampling and the measure ment of blood pressure using a transducer and a poly graph), a jugular vein (for fluid administration), and both ureters [15]. The left kidney was prepared for micropuncture as previously described [16], Following surgery, the rats were given an intra venous priming injection of inulin dissolved in isotonic NaCl. Plasma inulin concentration was maintained by continuous intravenous infusion of inulin in iso tonic NaCl given at 0.02 mi/min.…”

Section: Methodsmentioning

confidence: 99%

“…Inulin in these was determined spectrophotometrically (diphenylamine method) as previously described [16].…”

Section: Methodsmentioning

confidence: 99%

Tubulo-Glomerular Feedback in the Rat

Churchill

McDonald

1977

Nephron

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Using conventional micropuncture techniques in 53 adult Sprague-Dawley rats anesthetized with sodium pentobarbital, single nephron GFR at proximal sites (snGFR_prox) averaged 30 ± 1 nl/min (76 tubules) and at distal sites (snGFR_diS), 33 ± 2 nl/min (90 tubules). Thus, in spite of interruption of macula densa fluid flow during its measurement, snGFR_proX was not significantly greater than snGFR_diS (p > 0.05). Whole kidney GFR averaged 0.9 ± 0.07 ml/min before and 1.0 ± 0.05 ml/min during an intravenous infusion of SQ20,881, a substance which inhibits production of angiotensin II. Similarly, snGFR_diS was unaffected by SQ20,881; the mean difference between paired snGFRdis (collection during NaCl infusion minus recollection at same sites during SQ20,881 infusion) was 6 ± 4 nl/min (p > 0.5). These results suggest that under the conditions of the experiments, tubulo-glomerular feedback is not operative and that angiotensin II plays no role in controlling filtration.

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Renal Transport of Urea

Roch-Ramel¹,

Peters

1981

Proceedings in Life Sciences

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Excretion of urea by the rat kidney in isotonic saline diuresis: a micropuncture study

Cited by 4 publications

References 0 publications

Lack of an Effect of Saline Loading on Glycerol-Induced Acute Renal Failure

Lack of an Effect of Saline Loading on Glycerol-Induced Acute Renal Failure

Tubulo-Glomerular Feedback in the Rat

Renal Transport of Urea

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