Excretion of Vanilmandelic Acid in Normal and Clinical Conditions

History and Highlights of Finnish Pharmacology

“…In 50 schizophrenic pa tients they observed that nialamide therapy during five weeks decreased the urinary excretion of vanilmandelic acid to Y;3-Y<i of normal. Six months later it had not yet reverted to the normal level (98) .· Iisalo and associates demonstrated that propranolol inhibited the in crease of heart rate in the high temperature conditions of the Finnish sauna bath (99) and that ambulatory patients receiving alprenoloIl had signifi cantly less need of nitroglycerin than those on placebo (100).…”

Plasma noradrenaline and adrenaline in pre-eclampsia, essential hypertension in pregnancy and normotensive pregnant control subjects

“…In normotensive pregnancy catecholamine excretion was normal (Gemzell et al 1956;Zuspan 1970;Goodall & Diddle 1971) or increased (Bourdon et al 1978;Januszewicz et al (1978) measured reduced noradrenaline excretion early in pregnancy and increased adrenaline excretion late in pregnancy. In pre-eclampsia and eclampsia catecholamine excretion was increased (Zuspan 1972(Zuspan , 1979Zuspan & Kawada 1976) or normal (Pekkarinen & Castren 1968). Due to these divergent results concerning the sympathetic adrenergic activity evaluated by urinary catecholamine excretion, and since no systematic studies are available on plasma catecho¬ lamine levels in arterial hypertension in pregnancy, we determined plasma noradrenaline and adrenal¬ ine in pre-eclampsia and in patients with essential hypertension in pregnancy.…”