We consider a class of time-inhomogeneous optimal stopping problems and we provide sufficient conditions on the data of the problem that guarantee monotonicity of the optimal stopping boundary. In our setting, time-inhomogeneity stems not only from the reward function but, in particular, from the time dependence of the drift coefficient of the one-dimensional stochastic differential equation (SDE) which drives the stopping problem. In order to obtain our results, we mostly employ probabilistic arguments: we use a comparison principle between solutions of the SDE computed at different starting times, and martingale methods of optimal stopping theory. We also show a variant of the main theorem, which weakens one of the assumptions and additionally relies on the renowned connection between optimal stopping and free-boundary problems. 2020 Mathematics Subject Classification. 60G07, 60G40, 60J60, 49N30, 35R35. Key words and phrases. optimal stopping, monotone stopping boundary, time-inhomogeneous diffusions, partial information.1 Here, we mean that if (t, x) = (t, b(t)) and (tn, xn) → (t, x) as n → ∞, then τ * tn,xn → τ * t,x as n → ∞, P-a.s.