Exendin-4 as a Versatile Therapeutic Agent for the Amelioration of Diabetic Changes

Rajabi, Hadi; Ahmadi, Mahdi; Aslani, Somayeh; Saberianpour, Shirin; Rahbarghazi‬, Reza

doi:10.34172/apb.2022.025

Cited by 5 publications

(5 citation statements)

References 104 publications

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“…Although previous studies had hinted at this correlation [ 126 , 127 ], their investigation aimed to elucidate the molecular link between the two conditions. Exendin-4, a peptide agonist of the glucagon-like peptide receptor recognized for its role in insulin secretion and as a versatile therapeutic agent for diabetes, [ 128 ] was administered to APP/PS1 transgenic mice along with infliximab. This intervention resulted in a notable reduction in hippocampal serine phosphorylation of insuline receptor substrate-1 (IRS-1), an event frequently observed in both diabetes and AD [ 129 ].…”

Section: Evidence In Animal Models Of Alzheimer’s Diseasementioning

confidence: 99%

The Role of TNF-α in Alzheimer’s Disease: A Narrative Review

Plantone,

Pardini,

Righi

et al. 2023

Cells

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This review analyzes the role of TNF-α and its increase in biological fluids in mild cognitive impairment, and Alzheimer’s disease (AD). The potential inhibition of TNF-α with pharmacological strategies paves the way for preventing AD and improving cognitive function in people at risk for dementia. We conducted a narrative review to characterize the evidence in relation to the involvement of TNF-α in AD and its possible therapeutic inhibition. Several studies report that patients with RA and systemic inflammatory diseases treated with TNF-α blocking agents reduce the probability of emerging dementia compared with the general population. Animal model studies also showed interesting results and are discussed. An increasing amount of basic scientific data and clinical studies underscore the importance of inflammatory processes and subsequent glial activation in the pathogenesis of AD. TNF-α targeted therapy is a biologically plausible approach for cognition preservation and further trials are necessary to investigate the potential benefits of therapy in populations at risk of developing AD.

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Section: Evidence In Animal Models Of Alzheimer’s Diseasementioning

confidence: 99%

The Role of TNF-α in Alzheimer’s Disease: A Narrative Review

Plantone,

Pardini,

Righi

et al. 2023

Cells

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“…[70][71][72][73] Differentiation of MSCs into insulinproducing cells requires factors such as fibroblast growth factor (FGF), insulin-like growth factor 1 (IGF-1), and activin-A, which is a dimeric glycoprotein belonging to the transforming family growth factors-𝛽 (TGF-𝛽), a betacellulin protein encoded by the BTC gene on chromosome 4 at the 4q13-q21 locus in humans. [74][75][76][77][78][79] ). Paracrine factors secreted by MSCs have a variety of therapeutic effects, including anti-inflammatory, immunomodulatory, and tissue regenerative effects.…”

Section: Mechanism Of Differentiation Of Mscsmentioning

confidence: 99%

“…[ 70–73 ] Differentiation of MSCs into insulin‐producing cells requires factors such as fibroblast growth factor (FGF), insulin‐like growth factor 1 (IGF‐1), and activin‐A, which is a dimeric glycoprotein belonging to the transforming family growth factors‐β (TGF‐β), a betacellulin protein encoded by the BTC gene on chromosome 4 at the 4q13‐q21 locus in humans. [ 74–79 ]…”

Section: Mechanism Of Differentiation Of Mscsmentioning

confidence: 99%

Freeze‐Dried Mesenchymal Stem Cells: From Bench to Bedside. Review

Paresishvili,

Kakabadze

2023

Advanced Biology

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This review describes the freeze‐dried mesenchymal stem cells (MSCs) and their ability to restore damaged tissues and organs. An analysis of the literature shows that after the lyophilization MSCs retain >80% of paracrine factors and that the mechanism of their action on the restoration of damaged tissues and organs is similar to the mechanism of action of paracrine factors in fresh and cryopreserved mesenchymal stem cells. Based on the own materials, the use of paracrine factors of freeze‐dried MSCs in vivo and in vitro for the treatment of various diseases of organs and tissues has shown to be effective. The study also discusses about the advantages and disadvantages of freeze‐dried MSCs versus cryopreserved MSCs. However, for the effective use of freeze‐dried MSCs in clinical practice, a more detailed study of the mechanism of interaction of paracrine factors of freeze‐dried MSCs with target cells and tissues is required. It is also necessary to identify possible other specific paracrine factors of freeze‐dried MSCs. In addition, develop new therapeutic strategies for the use of freeze‐dried MSCs in regenerative medicine and tissue bioengineering.

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“…Production of neural 5-HT is under the control of a different regulatory gene than peripheral 5-HT, and 5-HT cannot readily cross the blood-brain barrier. GLP-1 has recently gained popularity as a therapeutic to combat type 2 diabetes (47)(48)(49), which is produced centrally by the PPGNs of the NTS (and to a lesser extent the OB). 5-HT has been shown to differentially modulate PPGNs via 5-HT 1A and 5-HT 2C receptors, respectively (24).…”

Section: Figure 2)mentioning

confidence: 99%

Involvement of a serotonin/GLP-1 circuit in adolescent isolation-induced diabetes

Kolling

Khan

Balasubramanian

et al. 2023

Preprint

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In 2020, stay-at-home orders were implemented to stem the spread of SARS-CoV-2 worldwide. Social isolation can be particularly harmful to children and adolescents during the pandemic, the prevalence of obesity increased by ~37% in persons aged 2-19. Obesity is often comorbid with type 2 diabetes, which was not assessed in this human pandemic cohort. Here, we investigated whether male mice isolated throughout adolescence develop type 2 diabetes in a manner consistent with human obesity-induced diabetes, and explored neural changes that may underlie such an interaction. We find that isolating C57BL/6J mice throughout adolescence is sufficient to induce type 2 diabetes. We observed fasted hyperglycemia, diminished glucose clearance in response to an insulin tolerance test, decreased insulin signaling in skeletal muscle, decreased insulin staining of pancreatic islets, increased nociception, and diminished plasma cortisol levels compared to group-housed control mice. Using Promethion metabolic phenotyping chambers, we observed dysregulation of sleep and eating behaviors, as well as a time-dependent shift in respiratory exchange ratio of the adolescent-isolation mice. We profiled changes in neural gene transcription from several brain areas and found that a neural circuit between serotonin-producing and GLP-1-producing neurons is affected by this isolation paradigm. Overall, spatial transcription data suggest decreased serotonin neuron activity (via decreased GLP-1-mediated excitation) and increased GLP-1 neuron activity (via decreased serotonin-mediated inhibition). This circuit may represent an intersectional target to further investigate the relationship between social isolation and type 2 diabetes, as well as a pharmacologically-relevant circuit to explore the effects of serotonin and GLP-1 receptor agonists.

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Exendin-4 as a Versatile Therapeutic Agent for the Amelioration of Diabetic Changes

Cited by 5 publications

References 104 publications

The Role of TNF-α in Alzheimer’s Disease: A Narrative Review

The Role of TNF-α in Alzheimer’s Disease: A Narrative Review

Freeze‐Dried Mesenchymal Stem Cells: From Bench to Bedside. Review

Involvement of a serotonin/GLP-1 circuit in adolescent isolation-induced diabetes

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