Exercise And Dietary Weight Loss In Overweight And Obese Older Adults With Knee OA

Effectiveness of Exercise Interventions in Reducing Pain Symptoms among Older Adults with Knee Osteoarthritis: A Review

“…Trials comparing aerobic-and strength-training interventions also demonstrated that both types of exercise interventions yielded signifi cant improvements in pain when compared with control interventions, with between-groups effect sizes ranging from small ) to large (Evcik & Sonel, 2002). Results from two trials (Messier et al, 2000(Messier et al, , 2004) also demonstrate that both exercise alone and exercise in combination with dietary weight loss improve pain in overweight or obese older adults, with signifi cant within-group improvements in pain symptoms ranging from 15% to 46%.…”

“…Five trials examined changes in pain after exercise interventions consisting of both aerobic-and strength-training components (Deyle et al, 2000;Fransen, Crosbie, & Edmonds, 2001;Hughes et al, 2004;Messier, Loeser, Miller, et al, 2004;Messier, Loeser, Mitchell, et al, 2000). Two trials comparing the effects of aerobic-and strength-training interventions are also summarized in this section of the review Evcik & Sonel, 2002).…”

“…Thus, although the exercise-alone and exercise + diet interventions produced signifi cant improvements in self-reported pain, the combination intervention resulted in greater improvements in body weight and mobility-related outcomes that are directly affected by body weight. Messier et al (2004) recently reported results from the Arthritis, Diet and Activity Promotion Trial (ADAPT). ADAPT was a single-blind, 18-month, randomized clinical trial comparing the effects of exercise alone, dietary weight loss alone, a combination of exercise and dietary weight loss, and a healthy-lifestyle control intervention on a variety of functional health outcomes in 316 overweight or obese older adults with knee OA.…”

Is Weight Loss Associated with Less Progression of Changes in Knee Articular Cartilage among Obese and Overweight Patients as Assessed with MR Imaging over 48 Months? Data from the Osteoarthritis Initiative

“…The following four sequences were used for the imaging analysis: (a) two-dimensional intermediate-weighted fast spin-echo sequence in the coronal plane (repetition time msec/echo time msec, 3700/29; field of view, 140 mm; matrix, 310 3 384); (b) twodimensional proton density-weighted fast spin-echo sequences with fat suppression in the sagittal plane (3200/30; field of view, 160 mm; matrix, 314 3 448); (c) three-dimensional dual-echo (BMI change ,3%, n = 1277), moderate weight loss (BMI decrease of 5%-10% [referred to hereafter as 5%-10% weight loss], n = 238), and substantial weight loss (BMI decrease .10%, n = 82). The weight loss groups were chosen on the basis of the weight loss goals of previous studies (5% weight loss in the Arthritis, Diet, and Activity Promotion Trial study; 10% in the Intensive Diet and Exercise for Arthritis study) (27)(28)(29), which suggest that these thresholds reflect the minimal amount of weight loss needed to improve clinical outcome (pain and function) in patients with knee osteoarthritis.…”

Is serum leptin related to physical function and is it modifiable through weight loss and exercise in older adults with knee osteoarthritis?

“…Owing to leptin's role in chondrocyte and osteophyte metabolism, changes in leptin concentrations may be one mechanism by which both dietary weight loss and exercise training interventions improve pain and physical function in older adults with knee OA. [25][26][27] Based on leptin's actions on energy balance, it is reasonable to speculate that the hormone plays a role in predicting weight change in a population, although results from previous studies in this area are conflicting. For example, in young nondiabetic, Pima Indians, those that gained weight over a 3-year period, had lower plasma leptin levels at baseline than those who maintained their weight.…”