Is Weight Loss Associated with Less Progression of Changes in Knee                    Articular Cartilage among Obese and Overweight Patients as Assessed with MR                    Imaging over 48 Months? Data from the Osteoarthritis Initiative

Gersing, Alexandra S.; Schwaiger, Benedikt J.; Nevitt, Michael C.; Joseph, Gabby B.; Chanchek, Nattagan; Guimarães, Júlio Brandão; Wamba, John Mbapte; Facchetti, Luca; McCulloch, Charles E.; Link, Thomas M.

doi:10.1148/radiol.2017161005

Cited by 68 publications

(86 citation statements)

References 63 publications

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“…Weight loss is reported to reduce knee OA symptoms and structural damage . The causal role of BMI in both knee and hip OA has recently been demonstrated in a previous study using first‐release data from the UK Biobank .…”

Section: Discussionmentioning

confidence: 86%

Causal Factors for Knee, Hip, and Hand Osteoarthritis: A Mendelian Randomization Study in the UK Biobank

Funck‐Brentano

Nethander

Movérare‐Skrtic

et al. 2019

Arthritis & Rheumatology

138

112

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Objective There is no curative treatment for osteoarthritis (OA), which is the most common form of arthritis. This study was undertaken to identify causal risk factors of knee, hip, and hand OA. Methods Individual‐level data from 384,838 unrelated participants in the UK Biobank study were analyzed. Mendelian randomization (MR) analyses were performed to test for causality for body mass index (BMI), bone mineral density (BMD), serum high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, and triglyceride levels, type 2 diabetes, systolic blood pressure (BP), and C‐reactive protein (CRP) levels. The primary outcome measure was OA determined using hospital diagnoses (all sites, n = 48,431; knee, n = 19,727; hip, n = 11,875; hand, n = 2,330). Odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated. Results MR analyses demonstrated a robust causal association of genetically determined BMI with all OA (OR per SD increase 1.57 [95% CI 1.44–1.71]), and with knee OA and hip OA, but not with hand OA. Increased genetically determined femoral neck BMD was causally associated with all OA (OR per SD increase 1.14 [95% CI 1.06–1.22]), knee OA, and hip OA. Low systolic BP was causally associated with all OA (OR per SD decrease 1.55 [95% CI 1.29–1.87]), knee OA, and hip OA. There was no evidence of causality for the other tested metabolic factors or CRP level. Conclusion Our findings indicate that BMI exerts a major causal effect on the risk of OA at weight‐bearing joints, but not at the hand. Evidence of causality of all OA, knee OA, and hip OA was also observed for high femoral neck BMD and low systolic BP. However, we found no evidence of causality for other metabolic factors or CRP level.

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Section: Discussionmentioning

confidence: 86%

Causal Factors for Knee, Hip, and Hand Osteoarthritis: A Mendelian Randomization Study in the UK Biobank

Funck‐Brentano

Nethander

Movérare‐Skrtic

et al. 2019

Arthritis & Rheumatology

138

112

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“…Also, Guimaraes showed that subjects who gained weight had increased progression of meniscal lesions compared to stable weight subjects over 48 months 15 . While Guimaraes et al did not find differences in progression of meniscal tears between weight loss and stable weight groups 15 , Gersing et al showed less progression of cartilage degeneration over 4 years weight loss compared to stable weight groups 17 . Another study found that substantial weight loss over 12 months was protective on the biochemical composition of cartilage (dGEMRIC) and reduced cartilage thickness losses 16 .…”

Section: Introductionmentioning

confidence: 92%

Effect of weight change on progression of knee OA structural features assessed by MRI in overweight and obese women

Landsmeer

Vos

Plas³

et al. 2018

Osteoarthritis and Cartilage

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“…Studies have shown an improvement of approximately 40% in pain and function, with a 10% reduction in body mass [21,22]. It is known that the decrease in body mass in overweight and OAJ subjects can lead to pain reduction, increase function, and reduce the progression of joint degeneration [11,14,23]. Conversely, a systematic review has shown that there is no relationship between BMI and the risk of developing PFP, both in adolescents and adults [8].…”

Section: Discussionmentioning

confidence: 99%

“…Despite the possible relationship between body weight and mechanical joint overload, the relationship between a high BMI and the development of PFP is controversial [8]. Regardless of this association, a conservative treatment approach recommends that individuals with knee pain lose weight, as this may lead to the improvement of pain and function related to this joint, as well as reduce the progression of joint degeneration [13,14].…”

Section: Introductionmentioning

confidence: 99%

Influence of body mass index on patellofemoral pain

et al. 2020

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Introduction: Patellofemoral Pain Syndrome is characterized by retro-patellar and peripatellar pain during squatting, kneeling and running whose intensity can be related to Body Mass Index (BMI). Objective: To evaluate the relationship between overweight, pain and function in women with Patellofemoral Pain Syndrome (PFPS). Method: Cross-sectional observational study of fifty-four women with PFPS assessed in the period between January and December 2015, in the physiotherapy outpatient clinic of a tertiary hospital in the city of São Paulo. To verify the variables of pain at rest, at effort and function, the Numerical Pain Rating Scale (NPRS) and the Kujala Anterior Knee Pain Scale (AKPS) were used. The participants were divided into two groups, according to the BMI categories defined by the World Health Organization (WHO): Group 1, composed of women with normal BMI (18-24.9 kg/m²), with 36 patients, and group 2 composed of overweight women (25-29.9 k/m²), with 18 patients. Comparison between groups of pain at rest and effort and AKPS were performed using Student's t-test and Mann-Witney with statistical significance p < 0,05. Results: There was no statistically significant difference between groups for the pain at rest and effort and for AKPS. Conclusion: BMI does not impact pain intensity and function in women with PFPS.

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Is Weight Loss Associated with Less Progression of Changes in Knee Articular Cartilage among Obese and Overweight Patients as Assessed with MR Imaging over 48 Months? Data from the Osteoarthritis Initiative

Cited by 68 publications

References 63 publications

Causal Factors for Knee, Hip, and Hand Osteoarthritis: A Mendelian Randomization Study in the UK Biobank

Causal Factors for Knee, Hip, and Hand Osteoarthritis: A Mendelian Randomization Study in the UK Biobank

Effect of weight change on progression of knee OA structural features assessed by MRI in overweight and obese women

Influence of body mass index on patellofemoral pain

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