Exercise and fluoxetine treatment during adolescence protect against early life stress-induced behavioral abnormalities in adult rats

Zolfaghari, Fatemeh; Pirri, Fardad; Gauvin, Evan; Peeri, Maghsoud; Amiri, Shayan

doi:10.1016/j.pbb.2021.173190

Cited by 20 publications

(12 citation statements)

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“…1. Finally, 20 studies [32,[51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69] met the predefined inclusion criteria and were included in the qualitative synthesis. Of the 20 included studies, 18 trials were suitable for quantitative synthesis (meta-analysis).…”

Section: Search Resultsmentioning

confidence: 99%

“…According to the pre-defined protocol, meta-analyses were performed based on data from the EPM and FST as these tests are the most frequently used for measuring anxiety-and depressive-like behavior in rodents, and supplemented with meta-analyses based on OF data to analyze influence of fluoxetine treatment on a basal locomotor activity. Stress-exposed animals were either subjected to neonatal maternal separation (during the first two weeks of life) [57,60,64,65,68], adolescent social isolation [63] plus social defeat procedure [58] or subthreshold chronic unpredictable mild stress paradigm (SCUMS) [69] (Table 2).…”

Section: Search Resultsmentioning

confidence: 99%

“…Three trials assessed anxiety-like behavior using a measure of time spent in the open arms of the EPM in stress-exposed rodents. Two studies used male rats [63,68] while one study was conducted on a female population [57]. Stress-inducing procedures included maternal separation during the first two weeks of life [57,68] or 4-week adolescent stress exposure induced by social isolation [63].…”

Section: Stress-exposed Animalsmentioning

confidence: 99%

“…Two studies used male rats [63,68] while one study was conducted on a female population [57]. Stress-inducing procedures included maternal separation during the first two weeks of life [57,68] or 4-week adolescent stress exposure induced by social isolation [63]. Fluoxetine doses ranged from 5 to 10 mg/kg/day.…”

Section: Stress-exposed Animalsmentioning

confidence: 99%

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Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents – systematic review and meta-analysis

2022

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Background Drugs prescribed for psychiatric disorders in adolescence should be studied very extensively since they can affect developing and thus highly plastic brain differently than they affect the adult brain. Therefore, we aimed to summarize animal studies reporting the behavioral consequences of chronic exposure to the most widely prescribed antidepressant drug among adolescents i.e., fluoxetine. Methods Electronic databases (Medline via Pubmed, Web of Science Core Collection, ScienceDirect) were systematically searched until April 12, 2022, for published, peer-reviewed, controlled trials concerning the effects of chronic fluoxetine administration vs. vehicle on anxiety and depression measures in naïve and stress-exposed adolescent rodents. All of the relevant studies were selected and critically appraised, and a meta-analysis of eligible studies was performed. Results A total of 18 studies were included in the meta-analysis. In naïve animals, chronic adolescent fluoxetine administration showed dose-related anxiogenic-like effects, measured as a reduction in time spent in the open arms of the elevated plus maze. No significant effects of chronic adolescent fluoxetine on depression-like behavior were reported in naïve animals, while in stress-exposed rodents chronic adolescent fluoxetine significantly decreased immobility time in the forced swim test compared to vehicle. Conclusions These results suggest that although chronic fluoxetine treatment proves positive effects in animal models of depression, it may simultaneously increase anxiety in adolescent animals in a dose-related manner. Although the clinical implications of the data should be interpreted with extreme caution, adolescent patients under fluoxetine treatment should be closely monitored.

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Section: Search Resultsmentioning

confidence: 99%

Section: Search Resultsmentioning

confidence: 99%

Section: Stress-exposed Animalsmentioning

confidence: 99%

Section: Stress-exposed Animalsmentioning

confidence: 99%

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Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents – systematic review and meta-analysis

2022

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“…Research over the recent decades have indicated that inflammation might be involved in the onset and development of depressive disorder (Beurel et al., 2020 ). Overactivation of inflammatory responses and increased levels of inflammatory mediators like interleukin (IL)−1β, IL‐6, tumor necrosis factor alpha (TNF‐α), the acute phase reactant (CRP), and high mobility group box 1 (HMGB1) were seen in both patients and rodents with depressive disorder (Cernackova et al., 2020 ; Liu et al., 2019 ; Xie et al., 2021 ; Zolfaghari et al., 2021 ). Our previous work focused mainly on the role of HMGB1, a late mediator of inflammation in depressive‐like behaviors (Wang et al., 1999 ).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Connexin 36 attenuates HMGB1‐mediated depressive‐like behaviors induced by chronic unpredictable mild stress

Jiang

Zeng

et al. 2022

Brain and Behavior

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Background: High mobility group box 1 (HMGB1) released by neurons and microglia was demonstrated to be an important mediator in depressive-like behaviors induced by chronic unpredictable mild stress (CUMS), which could lead to the imbalance of two different metabolic approaches in kynurenine pathway (KP), thus enhancing glutamate transmission and exacerbating depressive-like behaviors. Evidence showed that HMGB1 signaling might be regulated by Connexin (Cx) 36 in inflammatory diseases of central nervous system (CNS). Our study aimed to further explore the role of Cx36 in depressive-like behaviors and its relationship with HMGB1.Methods: After 4-week chronic stress, behavioral tests were conducted to evaluate depressive-like behaviors, including sucrose preference test (SPT), tail suspension test (TST), forced swimming test (FST), and open field test (OFT). Western blot analysis and immunofluorescence staining were used to observe the expression and location of Cx36. Enzyme-linked immunosorbent assay (ELISA) was adopted to detect the concentrations of inflammatory cytokines. And the excitability and inward currents of hippocampal neurons were recorded by whole-cell patch clamping. Results:The expression of Cx36 was significantly increased in hippocampal neurons of mice exposed to CUMS, while treatment with glycyrrhizinic acid (GZA) or quinine could both down-regulate Cx36 and alleviate depressive-like behaviors. The proinflammatory cytokines like HMGB1, tumor necrosis factor alpha (TNF-α), and interleukin-1β (IL-1β) were all elevated by CUMS, and application of GZA and quinine could decrease them. In addition, the enhanced excitability and inward currents of hippocampal neurons induced by lipopolysaccharide (LPS) could be reduced by either GZA or quinine.Conclusions: Inhibition of Cx36 in hippocampal neurons might attenuates HMGB1mediated depressive-like behaviors induced by CUMS through down-regulation of the proinflammatory cytokines and reduction of the excitability and intracellular ion overload.

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Voluntary wheel running during adolescence prevents the increase in ethanol intake induced by social defeat in male mice

Reguilón,

Ferrer-Pérez,

Manzanedo

et al. 2023

Psychopharmacology

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Rationale Exposure to social defeat (SD) induces a depressive phenotype, increased ethanol seeking and consumption, accompanied by activation of the neuroinflammatory response. However, a resilient response can be potentiated through physical exercise in the form of voluntary wheel running (VWR) during or after exposure to social stress. Therefore, the aim of this study was to test whether physical exercise during adolescence prior to being exposed to SD can enhance resilience to the increase in ethanol intake. Methods Male mice had access to VWR during adolescence and the effects of social defeat (4 sessions every 72 h) on oral ethanol self-administration (SA) was evaluated. Based on the social interaction test, mice were classified as resilient or susceptible to depressive-like behavior. Two weeks after the last encounter, mice were subjected to the drinking in the dark and oral ethanol SA paradigms. Mice were then sacrificed to measure brain-derived neurotrophic factor (BDNF) levels in the striatum and hippocampus. Results As expected, susceptible mice increased ethanol intake in the oral SA protocol. However, susceptible mice in the exercise condition did not increase ethanol intake, showing similar consumption and motivation for ethanol than the control and resilient groups. On the other hand, decreased BDNF levels were observed in susceptible mice in both experimental conditions compared to the control groups after ethanol SA. Conclusions The pre-exposure of VWR prevented the increase in consumption and motivation for ethanol induced by SD in susceptible mice. On the other hand, it appears that VWR did not exhibit any significant long-term effects on BDNF signaling, which is mainly affected in susceptible mice after ethanol intake.

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Exercise and fluoxetine treatment during adolescence protect against early life stress-induced behavioral abnormalities in adult rats

Cited by 20 publications

References 51 publications

Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents – systematic review and meta-analysis

Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents – systematic review and meta-analysis

Inhibition of Connexin 36 attenuates HMGB1‐mediated depressive‐like behaviors induced by chronic unpredictable mild stress

Voluntary wheel running during adolescence prevents the increase in ethanol intake induced by social defeat in male mice

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