Exercise as a coronary protective factor

Chandrashekhar, Y.; Anand, Inder

doi:10.1016/0002-8703(91)90290-x

Cited by 73 publications

(31 citation statements)

References 199 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Benefits to the circulatory system include influences on the lipoprotein metabolism, inflammatory markers, endothelial function and insulin resistance. [39][40][41][42][43][44][45][46] Is physical activity important among those who lose weight? Our study showed that leisure time physical activity had protective effect on all-cause mortality, which is in line with numerous other studies.…”

Section: Discussionmentioning

confidence: 99%

Combined effects of weight loss and physical activity on all-cause mortality of overweight men and women

et al. 2010

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Combined effects of weight loss and physical activity on all-cause mortality of overweight men and women

et al. 2010

View full text Add to dashboard Cite

show abstract

“…However, exercise, particularly when it is not exhaustive, is clearly a healthy practice that results in the prevention of many diseases. For instance, exercise minimises atherognesis induced by diet (19) and has been considered as a cardioprotective factor (20).…”

Section: Training Protects Against Free-radical Formation In Exhaustimentioning

confidence: 99%

Free Radicals in Exhaustive Physical Exercise: Mechanism of Production, and Protection by Antioxidants

et al. 2000

View full text Add to dashboard Cite

SummaryModerate exercise is a healthy practice. However, exhaustive exercise generates free radicals. This can be evidenced by increases in lipid peroxidation, glutathione oxidation, and oxidative protein damage. It is well known that activity of cytosolic enzymes in blood plasma is increased after exhaustive exercise. This may be taken as a sign of damage to muscle cells. The degree of oxidative stress and of muscle damage does not depend on the absolute intensity of exercise but on the degree of exhaustion of the person who performs exercise. Training partially prevents free radical-formation in exhaustive exercise. Treatment with antioxidants such as vitamins C or E protects in part against free radical-mediated damage in exercise. Xanthine oxidase is involved in free-radical formation in exercise in humans and inhibition of this enzyme with allopurinol decreases oxidative stress and muscle damage associated with exhaustive exercise. Knowledge of the mechanism of free-radical formation in exercise is important because it will be useful to prevent oxidative stress and damage associated with exhaustive physical activity. IUBMB Life, 50: 271 -277, 2000

show abstract

“…A higher degree of or an increase in physical activity or physical fitness is associated with a lower risk of mortality or incidence of cardiovascular diseases [1±8], independent of several cardiovascular risk factors including smoking, obesity, blood pressure, serum lipids, socioeconomic status and diabetes [3±5].Physical activity also has a beneficial effect on many cardiovascular risk factors [2]. A higher degree of physical activity has been associated with a lower incidence of Type-II (non-insulin-dependent) diabetes mellitus [9] and a lower degree of insulin resistance [10,11].…”

mentioning

confidence: 99%

“…Physical activity also has a beneficial effect on many cardiovascular risk factors [2]. A higher degree of physical activity has been associated with a lower incidence of Type-II (non-insulin-dependent) diabetes mellitus [9] and a lower degree of insulin resistance [10,11].…”

mentioning

confidence: 99%

Changes in physical activity are associated with changes in metabolic cardiovascular risk factors

2001

View full text Add to dashboard Cite

Several studies have shown a beneficial effect of physical activity and exercise on health. A higher degree of or an increase in physical activity or physical fitness is associated with a lower risk of mortality or incidence of cardiovascular diseases [1±8], independent of several cardiovascular risk factors including smoking, obesity, blood pressure, serum lipids, socioeconomic status and diabetes [3±5].Physical activity also has a beneficial effect on many cardiovascular risk factors [2]. A higher degree of physical activity has been associated with a lower incidence of Type-II (non-insulin-dependent) diabetes mellitus [9] and a lower degree of insulin resistance [10,11]. Fasting concentrations of (immunore- Diabetologia (2001) Abstract Aims/hypothesis. To investigate the effect of changes in physical activity on changes in metabolic cardiovascular risk factors and to investigate what factors affect the association between physical activity and cardiovascular mortality. Methods. Of the 1860 men who were 50 years of age and who were without pre-existing cardiovascular disease participating in a population-based study, 898 were re-examined 20 years later. Altogether 231 died from cardiovascular diseases during the followup (mean = 22.6 years). The examinations which the men underwent at 50 and 70 years of age included assessment of physical activity (self-reported at four alternative levels), anthropometry, measurements of fasting concentrations of glucose, specific insulin, proinsulin, split proinsulin and lipids. Results. During the 20 years, 31 % increased their amount of physical activity while 51 % continued the same amount of exercise. Increased physical activity was associated with significant changes in several important metabolic variables, including fasting glucose, proinsulin and HDL cholesterol, independent of body weight changes. The risk of cardiovascular disease for men performing moderate, regular and athletic physical activity was 25 % (p = 0.127), 34 % (p = 0.022) and 71 % (p = 0.009) lower, respectively, compared with sedentary men. The association was attenuated by adjustment for baseline measurements of insulin, proinsulin and split proinsulin. Additional adjustment for other cardiovascular risk factors did not further attenuate the association. Conclusion/interpretation. Increased leisure time physical activity between the ages of 50 and 70 years, in the absence of active intervention, is associated with improved glucose, insulin and lipid metabolism in men. The concentrations of insulin, proinsulin and split proinsulin could mediate much of the association between a sedentary lifestyle and increased risk of cardiovascular mortality. [Diabetologia (2001)

show abstract

Exercise as a coronary protective factor

Cited by 73 publications

References 199 publications

Combined effects of weight loss and physical activity on all-cause mortality of overweight men and women

Combined effects of weight loss and physical activity on all-cause mortality of overweight men and women

Free Radicals in Exhaustive Physical Exercise: Mechanism of Production, and Protection by Antioxidants

Changes in physical activity are associated with changes in metabolic cardiovascular risk factors

Contact Info

Product

Resources

About