Exercise as a treatment for sarcopenia: an umbrella review of systematic review evidence

Moore, Sarah A.; Hrisos, Nina; Errington, Linda; Rochester, Lynn; Rodgers, Helen; Witham, Miles D.; Sayer, Avan A.

doi:10.1016/j.physio.2019.08.005

Cited by 46 publications

(47 citation statements)

References 37 publications

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“…The treatment of sarcopenia is currently limited to physical exercise and su cient protein intake [31][32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Sarcopenia in metastatic cancer patients: results of a prospective non-randomized study.

Dubu¹,

Septans²,

Dômont³

et al. 2021

Preprint

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Background Prognostic factors can impact the quality of life and overall survival in metastatic situations: sarcopenia and nutritional status disorders. Methods We conducted a non-interventional, observational prospective study during 3 consecutive months (SPACE trial, ClinicalTrials.gov identifier: NCT04714203). Performance status, lumbar skeletal muscle index (by CT scan), albumin, C-reactive protein, or LDH, were collected from medical records in the classic balance sheet at inclusion and then at 3 and 6 months after the day of inclusion. Results 38 patients were included with a median age of 68 years old and 31 were evaluable for sarcopenia. 58.1% of patients with metastatic cancer were sarcopenic at the diagnosis and 61% at 6 months. At the inclusion, 87.5% of sarcopenic patients were men (p < 0.0002) and sarcopenia status was associated with lung localization (p < 0.0332) and non-operable cancer (p < 0.0069). Conclusion The majority of patients in our study were sarcopenic at the inclusion and at 6 months. However, the number of patients was too small to correlate sarcopenia with survival. Further larger studies are needed to establish stronger results. In the future, sarcopenic patients could benefit from specialized care with nutrition and adapted physical activity.

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“…The treatment of sarcopenia is currently limited to physical exercise and su cient protein intake [31][32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Sarcopenia in metastatic cancer patients: results of a prospective non-randomized study.

Dubu¹,

Septans²,

Dômont³

et al. 2021

Preprint

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“…First, we only assessed the post-intervention effects of the two exercise programs; however, the long-term outcomes are supposed to be more important in older patients with sarcopenia. According to a recent overview of systematic reviews, this was a common limitation shared across the relevant literature 11 . Therefore, the long-term effectiveness of different exercise programs needs to be evaluated in the future.…”

Section: Discussionmentioning

confidence: 99%

“…Resistance exercise is the most commonly suggested exercise regimen for sarcopenia by recent consensuses 2 , 4 . However, a recent overview of systematic reviews indicated that the majority of exercise interventions for sarcopenia were mixed exercise programs including aerobic, balance, and resistance exercise (instead of resistance exercise alone) 11 . Whether mixed exercise programs are better than resistance exercise alone for sarcopenic patients has not been reported.…”

Section: Introductionmentioning

confidence: 99%

A randomized controlled trial of resistance and balance exercise for sarcopenic patients aged 80–99 years

Liang

Wang

Jiang

et al. 2020

Sci Rep

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We compared a mixed exercise program (i.e., balance exercise plus resistance exercise) with resistance exercise in a single-blind, randomized controlled trial in a post-acute care unit. In total, 60 sarcopenic patients were randomly assigned to an intervention group (12-week mixed exercise) and a control group (12-week resistance exercise). The primary outcomes were the change of the Barthel Index and the number of fallers. The intervention group showed a mean increase of 9.5 points on the Barthel Index (95% confidence interval (CI) 3.9–15.1), while the control group showed a mean increase of 6.3 points (95% CI 2.3–10.4). The mixed exercise program provided a significant benefit over resistance exercise (adjusted mean difference of the change of Barthel Index: 6.8 points; 95% CI 1.4–12.1). The number of fallers was 13.3% and 23.3% in the intervention and control groups, respectively, but the difference was not significant (risk ratio (RR) 0.89, 95% CI 0.69–1.13, p = 0.506). In conclusion, compared with resistance exercise, the mixed exercise program appears to further improve the activities of daily living and physical performance in our study population. Under the monitoring of experienced physiotherapists, both exercise programs are feasible and safe for this population.

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“…Recent consensus guidance recommends that those at risk of, or with established sarcopenia or frailty, should be offered exercise training with a prominent resistance component (which can be part of a multimodal exercise programme) 11 systematic reviews examining the impact of differences in exercise intensity in trials for sarcopenia or frailty note that although training gains can be achieved at <50% 1-repetition maximum (1RM) intensity, the best results are seen at 80% of 1RM or higher 12 . Most exercise programmes included in systematic reviews for both sarcopenia and frailty have delivered 2-3 training sessions per week for at least 10 weeks; the mean programme duration for trials conducted with older people living with frailty was 23 weeks [13][14][15] . If exercise training in sarcopenia or frailty is to be based on current evidence, such programmes should therefore deliver exercise training with the above characteristics of modality, intensity, duration and frequency.…”

Section: Introductionmentioning

confidence: 99%

Content of exercise programmes targeting older people with sarcopenia or frailty – findings from a UK survey

Witham¹,

Chawner²,

Biase³

et al. 2020

JFSF

Self Cite

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Objectives: To establish whether existing exercise programmes offered to people with sarcopenia or frailty adhere to the current evidence base. Methods: We conducted a national survey of practitioners delivering exercise programmes to older people with sarcopenia or frailty in the UK. The link to the online survey was distributed through email lists of professional societies, practice networks and social media. Questions covered target population and programme aims, type, duration and frequency of exercise, progress assessment and outcome measures. Results: One hundred and thirty-six responses were received. 94% of respondents reported prescribing or delivering exercise programmes to people with sarcopenia or frailty. Most programmes (81/135 [60%]) were primarily designed to prevent or reduce falls. Resistance training was the main focus in only 11/123 (9%), balance training in 61/123 (50%) and functional exercise in 28/123 (23%). Exercise was offered once a week or less by 81/124 (65%) of respondents. Outcome measures suitable for assessing the effect of resistance training programmes were reported by fewer than half of respondents (hand grip: 13/119 [11%]; chair stands: 55/119 [46%]). Conclusions: Current UK exercise programmes offered to older people with sarcopenia or frailty lack the specificity, frequency or duration of exercise likely to improve outcomes for this patient group.

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Exercise as a treatment for sarcopenia: an umbrella review of systematic review evidence

Cited by 46 publications

References 37 publications

Sarcopenia in metastatic cancer patients: results of a prospective non-randomized study.

Sarcopenia in metastatic cancer patients: results of a prospective non-randomized study.

A randomized controlled trial of resistance and balance exercise for sarcopenic patients aged 80–99 years

Content of exercise programmes targeting older people with sarcopenia or frailty – findings from a UK survey

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