2007
DOI: 10.2337/dc06-2487
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Exercise Capacity and Cardiovascular/Metabolic Characteristics of Overweight and Obese Individuals With Type 2 Diabetes

Abstract: Individuals with diabetes who are overweight or obese have impaired exercise capacity, which is primarily related to age, female sex, and race, as well as poor metabolic control, BMI, and central obesity.

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Cited by 85 publications
(82 citation statements)
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“…Impairments in left ventricular diastolic dysfunction, oxygen uptake kinetic response, endothelial vasodilator function and muscle oxidative enzyme capacity along with arterial stiffness and inflammation are believed to contribute to exercise intolerance in individuals with diabetes (Stewart 2002;2003;Ribisl, Lang et al 2007). …”
Section: Decline In Cardiorespiratory Fitness Associated With Type 2 mentioning
confidence: 99%
“…Impairments in left ventricular diastolic dysfunction, oxygen uptake kinetic response, endothelial vasodilator function and muscle oxidative enzyme capacity along with arterial stiffness and inflammation are believed to contribute to exercise intolerance in individuals with diabetes (Stewart 2002;2003;Ribisl, Lang et al 2007). …”
Section: Decline In Cardiorespiratory Fitness Associated With Type 2 mentioning
confidence: 99%
“…Impaired walking capacity is common in obese subjects not only because it is a weight-bearing activity. Obese subjects also have a lower level of exercise capacity and significant comorbidities such as musculoskeletal pain (10)(11)(12). There is a need for clinical tests evaluating obesity per se as well as the effect of intervention that go beyond the actual weight loss.…”
Section: Introductionmentioning
confidence: 99%
“…Our group and others have demonstrated that maximal oxygen uptake is reduced as much as 40% in youth with severe insulin resistance (McGavock et al 2004a(McGavock et al ,b, 2009Ribisl et al 2007). This defect in whole body oxidative metabolism not only impairs exercise capacity, but also is one of the best prognostic indicators of cardiovascular mortality in patients with T2D (Wei et al 2000).…”
mentioning
confidence: 85%