Background: Through the years, breast cancer management evolved toward conservation surgery. It is obvious that the clinical management requires a multidisciplinary approach to restoration of activity if daily living and quality of life after modified radical mastectomy. Aims and Objectives: The objectives of the study were to measure pain after physiotherapy intervention, to measure chest expansion after physiotherapy intervention, and to measure and improve shoulder range of motion (ROM) after physiotherapy intervention. Materials and Methods: This was a cross-experimental study in which initial data were recorded from the medical records, and then, after assuming proper resting status of the patient, the patients were assessed first numeric pain rating scale (NRS) for pain, ROM of shoulder joint, and chest expansion before and after the physiotherapy treatment given till patient get discharged. Results: In the present study, a total of 7 participants were included who fulfilled inclusion criteria. All the participants underwent routine physiotherapy treatment started from the day 1 till discharged, and NRS for pain, ROM of shoulder joint, and chest expansion all parameters were statistically significant (P < 0.005). Conclusion: The present study concluded that physiotherapy is more effective in modified radical mastectomy.