Exercise hyperventilation in patients with McArdle's disease

Hagbèrg, James M.; Coyle, Edward F.; Carroll, James E.; Miller, J. M.; Martin, W. H.; Brooke, Michael H.

doi:10.1152/jappl.1982.52.4.991

Cited by 186 publications

(82 citation statements)

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“…Additionally, exogenous administration of lactate does not cause appreciable dilation (247). Finally, patients with McArdle's disease (myophosphorylase deficiency) do not produce lactic acid even in response to heavy exercise (189,276,277). These patients also show a hyperdynamic circulatory response to exercise, indicating that their vasodilator responses to exercise are excessive in the absence of lactic acid production.…”

Section: Potassium and Osmolaritymentioning

confidence: 99%

Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy of Competing Physiological Needs

Joyner

Casey

2015

Physiological Reviews

581

513

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LJoyner MJ, Casey DP. Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy of Competing Physiological Needs. Physiol Rev 95: 549 -601, 2015; doi:10.1152/physrev.00035.2013.-This review focuses on how blood flow to contracting skeletal muscles is regulated during exercise in humans. The idea is that blood flow to the contracting muscles links oxygen in the atmosphere with the contracting muscles where it is consumed. In this context, we take a top down approach and review the basics of oxygen consumption at rest and during exercise in humans, how these values change with training, and the systemic hemodynamic adaptations that support them. We highlight the very high muscle blood flow responses to exercise discovered in the 1980s. We also discuss the vasodilating factors in the contracting muscles responsible for these very high flows. Finally, the competition between demand for blood flow by contracting muscles and maximum systemic cardiac output is discussed as a potential challenge to blood pressure regulation during heavy large muscle mass or whole body exercise in humans. At this time, no one dominant dilator mechanism accounts for exercise hyperemia. Additionally, complex interactions between the sympathetic nervous system and the microcirculation facilitate high levels of systemic oxygen extraction and permit just enough sympathetic control of blood flow to contracting muscles to regulate blood pressure during large muscle mass exercise in humans.

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Section: Potassium and Osmolaritymentioning

confidence: 99%

Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy of Competing Physiological Needs

Joyner

Casey

2015

Physiological Reviews

581

513

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“…Entretanto, nessa intensidade não se verifica diminuição significante do pH sanguíneo 8,9 . Para eventos fisiológicos ocorridos nessa intensidade de exercício, a percentagem do consumo de oxigênio de pico verificada no LV 1 ficou levemente acima da faixa de variação do modelo hipotético proposto por Skinner & McLellan 10 .…”

Section: Resultsunclassified

“…Foram avaliadas 37 jogadoras de futebol, com média de idade de 21,5 ± 5,9 anos (14-34), peso de 57,0 ± 8,3kg (45-79), estatura de 161 ± 7cm (146-179), índice de massa corpó-rea (IMC) de 21,8 ± 2,1kg.m 2 (18,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)3). Suas característi-cas cardiovasculares em repouso estão listadas na tabela 1.…”

Section: Methodsunclassified

Perfil de limiares ventilatórios durante o exercício e o consumo de oxigênio de pico verificado em jogadoras de futebol

Silva¹,

Andrade²,

Riça³

et al. 1999

Rev Bras Med Esporte

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Ventilatory threshold profile during exercise and peak oxygen uptake verified in female soccer playersThirty-seven female soccer players aged 21.5 ± 5.9, weight 57.0 ± 8.3 kg, height INTRODUÇÃOO futebol feminino para o mundo ainda não é uma realidade. Tradicionalmente, ele tem sido praticado por homens, o que de certo modo tem inibido a coragem de muitas mulhe- RESUMOForam avaliadas 37 jogadoras de futebol, com média de idade de 21,5 ± 5,9 anos, peso de 57,0 ± 8,3kg, estatura de 161 ± 7cm e índice de massa corpórea de 21,8 ± 2,1kg/m 2 . Todas as atletas foram submetidas à avaliação espirométrica e metabólica, por meio de um sistema computadorizado de aná-lise de gases expirados (modelo Vmax 29c, SensorMedics, EUA). A resposta cardiovascular foi verificada por meio de um eletrocardiógrafo computadorizado (modelo 6.4, HeartWare, BRA). A capacidade física máxima foi avaliada por meio de teste de esforço realizado em esteira rolante (modelo ATL-10.100, Inbramed, BRA) utilizando-se protocolo escalonado contínuo. Os seguintes parâmetros e os resultados encontrados foram: no limiar ventilatório 1 (LV 1 ): VO 2 = 30,5 ± 3,7ml O 2 .kg -1 .min -1 ; % VO 2 = 64 ± 7%; velocidade de corrida = 8,1 ± 0,3km.h -1 ; FC = 154 ± 9bpm. No limiar ventilatório 2 (LV 2 ): VO 2 = 40,9 ± 4,5ml O 2 .kg -1 .min -1 ; % VO 2 = 85,7 ± 4,9%; velocidade de corrida = 11,4 ± 1,1km.h -1 ; FC = 179 ± 7bpm. O VO 2 de pico foi de 47,4 ± 4,1ml O 2 .kg -1 .min -1 . Conclusão: a verificação de limiares ventilatórios e a potência aeróbia em jogadoras de futebol são parâmetros fisiológicos de grande importância, pois permitem ampliar suas aplicações práticas,

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“…Recently, there have been several studies wherein VT is not always consistent with LT (GREEN et al, 1983;SIMoN et al, 1983;POWERS et al, 1984;GLADDEN et al, 1985), and which are negative about the cause-effect relationship between LT and VT (HAGBERG et al, 1982;HUGHES et al, 1982). Only two studies (GREEN et al, 1983;GLADDEN et al, 1985) reported a disassociation of LT and VT, using the objective method for determining both LT and VT. GREEN et al (1983) showed that VT occurred at a significantly higher work rate than LT, and GLADDEN et al (1985) showed that agreement between both was poor (r=0.29).…”

Section: Methodsmentioning

confidence: 99%

Comparison of objective methods for determining ventilatory threshold.

et al. 1988

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This study was undertaken to compare and re-examine the relation of lactate threshold (LT) and ventilatory threshold (VT), using six objective determination methods proposed previously. Twenty-one young male subjects performed a cycle exercise test in which the work rate was increased by 150 kg m every 2 min up to his limit of volitional fatigue. Through each test, gas exchange parameter measurements were made every 1 min (every 30s at nearly maximal level), and the venous blood samples were taken from a warmed ear lobe at each work rate for determining blood lactate concentration. LT and its variance were determined by the intersecting straight lines regression. LT ranged from 0.72 to 1.401/min in terms of V02 , and the mean value of S.D. for each LT was about 0.11/min. Each objective method for determining VT used in this study was based on the simple modelling of the criterion for visual detection of VT, that is the non-linear increase in VE or the systematic increase in VE/Voz. When the relationship between LT and VT was examined, VT by the objective methods based on determining minimum value of VE/Voz showed relatively high consistency with LT. Of 16-20 individuals out of all 21 subjects, there were VT within LT + 0.2 in Voz. It is concluded that VE/Voz is a more sensitive index for detecting VT than VE in the gas exchange parameters, and the objective VT determination method based on minimum value of VE/Voz could facilitate estimation of LT within an error of + 0.2 1/mmn Voz in most normal individuals.

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Exercise hyperventilation in patients with McArdle's disease

Cited by 186 publications

References 0 publications

Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy of Competing Physiological Needs

Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy of Competing Physiological Needs

Perfil de limiares ventilatórios durante o exercício e o consumo de oxigênio de pico verificado em jogadoras de futebol

Comparison of objective methods for determining ventilatory threshold.

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