Exercise in neuromuscular disease

Anziska, Yaacov; Sternberg, Alex

doi:10.1002/mus.23771

Cited by 59 publications

(37 citation statements)

References 215 publications

(384 reference statements)

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“…As the loss of motoneurons in old age is an irreversible process, it is important to understand the mechanisms that bring about the preservation of motoneurons through physical activity (Anziska & Sternberg, 2013). In this context, the protective effect of neurotrophic factors on motoneurons, the release of which is to be determined by neuromuscular activity, shall be discussed (Ogborn & Gardiner, 2010).…”

Section: Munix and Muscle Mass: Master Athletes Versus Community-dwelmentioning

confidence: 99%

Relation between muscle mass, motor units and type of training in master athletes

Drey

Sieber

Degens

et al. 2014

Clin Physio Funct Imaging

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The present data of master athletes are compatible with the hypothesis of an age-related decline in whole body muscle mass and motor units. Nevertheless, the data suggest that the master athletes' high level of physical activity may protect motoneurons. In addition, power training seems to have a positive effect on muscle mass and could therefore be an effective method of training to prevent sarcopenia.

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Section: Munix and Muscle Mass: Master Athletes Versus Community-dwelmentioning

confidence: 99%

Relation between muscle mass, motor units and type of training in master athletes

Drey

Sieber

Degens

et al. 2014

Clin Physio Funct Imaging

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“…Several systematic reviews have synthesised the available evidence of exercise in general neuromuscular disorders, reporting numerous benefits (Neill et al, 2006;Cup et al, 2007;Hall et al, 2008;Dibble et al, 2009;Clauw, 2014). Only one recent review (Anziska and Sternberg, 2013) provided an overview of exercise studies conducted in CMT, however, no methodology for the selection of studies was included, nor were the studies critiqued. Information regarding safe levels of exercise, such as the optimal amount, frequency, timing, and type of exercise to optimise function may assist in the development of exercise guidelines.…”

Section: Introductionmentioning

confidence: 99%

Systematic review of exercise for Charcot‐Marie‐Tooth disease

Sman

Hackett

Singh

et al. 2015

J Peripheral Nervous Sys

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Charcot-Marie-Tooth disease (CMT) is a slowly progressive hereditary degenerative disease and one of the most common neuromuscular disorders. Exercise may be beneficial to maintain strength and function for people with CMT, however, no comprehensive evaluation of the benefits and risks of exercise have been conducted. A systematic review was completed searching numerous electronic databases from earliest records to February 2015. Studies of any design including participants of any age with confirmed diagnosis of CMT that investigated the effects of exercise were eligible for inclusion. Of 13,301 articles identified following removal of duplicates, 11 articles including 9 unique studies met the criteria. Methodological quality of studies was moderate, sample sizes were small, and interventions and outcome measures used varied widely. Although the majority of the studies identified changes in one or more outcome measurements across exercise modalities, the majority were non-significant, possibly due to Type II errors. Significant effects described included improvements in strength, functional activities, and physiological adaptations following exercise. Despite many studies showing changes in strength and function following exercise, findings of this review should be met with caution due to the few studies available and moderate quality of evidence. Well-powered studies, harmonisation of outcome measures, and clearly described interventions across studies would improve the quality and comparability of the evidence base. The optimal exercise modality and intensity for people with CMT as well as the long-term safety of exercise remain unclear.

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“…Clinicians do not encourage patients with SMA to participate in PRT due to the lack of definitive literature disputing the long‐standing concern about performing PRT in NMD. Therefore, given the encouraging results in the animal model of SMA and in studies of adults with NMD, and the historical clinical practice of not prescribing participation in PRT to individuals with SMA further research is needed.…”

mentioning

confidence: 99%

“…44 Widely accepted PRT recommendations in pediatrics include providing supervision, targeting all major muscle groups, including a warm-up and cool-down period, and performing 2-3 sets of 8-15 repetitions. 37,40,41,45 Clinicians do not encourage patients with SMA to participate in PRT 46,47 due to the lack of definitive literature disputing the long-standing concern about performing PRT in NMD. Therefore, given the encouraging results in the animal model of SMA and in studies of adults with NMD, and the historical clinical practice of not prescribing participation in PRT to individuals with SMA further research is needed.…”

mentioning

confidence: 99%

Resistance strength training exercise in children with spinal muscular atrophy

et al. 2015

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Introduction Preliminary evidence in adults with spinal muscular atrophy (SMA) and in SMA animal models suggests exercise has potential benefits in improving or stabilizing muscle strength and motor function. Methods We evaluated feasibility, safety, and effects on strength and motor function of a home-based, supervised progressive resistance strength training exercise program in children with SMA types II and III. Up to 14 bilateral proximal muscles were exercised 3 times weekly for 12 weeks. Results Nine children with SMA, aged 10.4±3.8 years, completed the resistance training exercise program. Ninety percent of visits occurred per protocol. Training sessions were pain-free (99.8%), and no study-related adverse events occurred. Trends in improved strength and motor function were observed. Conclusions A 12-week supervised, home-based, 3 days/week progressive resistance training exercise program is feasible, safe, and well tolerated in children with SMA. These findings can inform future studies of exercise in SMA.

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Exercise in neuromuscular disease

Cited by 59 publications

References 215 publications

Relation between muscle mass, motor units and type of training in master athletes

Relation between muscle mass, motor units and type of training in master athletes

Systematic review of exercise for Charcot‐Marie‐Tooth disease

Resistance strength training exercise in children with spinal muscular atrophy

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