Exercise increases endostatin in circulation of healthy volunteers

Gu, Jian‐Wei; Gadonski, Giovani; Wang, Julie; Makey, Ian A.; Adair, Thomas H.

doi:10.1186/1472-6793-4-2

Cited by 46 publications

(24 citation statements)

References 32 publications

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“…Some researchers have reported minor, time dependent fluctuations in the arterial-venous difference in plasma endostatin levels, but no change in tissue endostatin levels, following an acute exercise bout (787). Others have reported increases in circulating endostatin in response to exercise (322, 893), although muscle levels of endostatin decrease after exercise training (323). Endostatin levels are increased in skeletal muscle of diabetic patients compared to non-diabetic controls (873), suggesting that endostatin may play a role in maintaining an angiostatic environment in the muscle of diabetic patients.…”

Section: Training Adaptations Within the Active Muscle: Increased mentioning

confidence: 99%

Exercise Training and Peripheral Arterial Disease

Haas

Lloyd

Yang

et al. 2012

Comprehensive Physiology

120

108

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Peripheral arterial disease (PAD) is a common vascular disease that reduces blood flow capacity to the legs of patients. PAD leads to exercise intolerance that can progress in severity to greatly limit mobility, and in advanced cases leads to frank ischemia with pain at rest. It is estimated that 12–15 million people in the United States are diagnosed with PAD, with a much larger population that is undiagnosed. The presence of PAD predicts a 50–1500% increase in morbidity and mortality, depending on severity. Treatment of patients with PAD is limited to modification of cardiovascular disease risk factors, pharmacological intervention, surgery, and exercise therapy. Extended exercise programs that involve walking ~5 times/wk, at a significant intensity that requires frequent rest periods, are most significant. Pre-clinical studies and virtually all clinical trials demonstrate the benefits of exercise therapy, including: improved walking tolerance, modified inflammatory/hemostatic markers, enhanced vasoresponsiveness, adaptations within the limb (angiogenesis, arteriogenesis, mitochondrial synthesis) that enhance oxygen delivery and metabolic responses, potentially delayed progression of the disease, enhanced quality of life indices, and extended longevity. A synthesis is provided as to how these adaptations can develop in the context of our current state of knowledge and events known to be orchestrated by exercise. The benefits are so compelling that exercise prescription should be an essential option presented to patients with PAD in the absence of contraindications. Obviously, selecting for a life style pattern, that includes enhanced physical activity prior to the advance of PAD limitations, is the most desirable and beneficial.

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Section: Training Adaptations Within the Active Muscle: Increased mentioning

confidence: 99%

Exercise Training and Peripheral Arterial Disease

Haas

Lloyd

Yang

et al. 2012

Comprehensive Physiology

120

108

View full text Add to dashboard Cite

show abstract

“…As Van Craenenbroeck et al (24) showed, the serum levels of VEGF increased after acute exercise. On the other hand, Suhr et al (14) reported no change in serum VEGF following acute exercise while Gu et al (25) reported a decrease in serum VEGF concentration.…”

Section: Discussionmentioning

confidence: 99%

Effect of Resistance Training and Berberine Chloride Supplementation on IGF-1, PDGF, and VEGF Gene Expression in Hippocampal Tissue of Diazinon-Poisoned Rats

Far

Azarbayjani

Peeri

et al. 2019

Thrita

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Background:One of the most common agricultural pesticides is organophosphorus pesticides. Diazinon is one of the most widely used organophosphorus pesticides used in the fight against pesticides in the country. Much research has recently been done on the impact of exercise on brain function and several biological mechanisms have been proposed for the effects of exercise and physical activity on brain function. It is said that resistance training increases neuronal plasticity due to an increase in insulin-like growth factor-1 (IGF-1). Research has shown that IGF-1 can cross the blood-brain barrier and play an important role as a neurotrophic factor, especially in the hippocampus, and activate various important central mechanisms related to cognitive processes. Exercise also affects the expression of angiogenic genes such as PDGF and VEGF. Methods:We randomly divided 40 male Wistar rats weighing 250 ± 50 g into eight groups of five and treated them with diazinon, berberine chloride, and resistance training. The groups were treated for five weeks. At the end of the fifth week, the levels of IGF-1, PDGF, and VEGF gene expression in hippocampal tissue homogenates were measured using Quantitative real-time PCR. Data were analyzed using ANOVA and Tukey's post hoc test. Results: The results showed that resistance training and berberine chloride significantly increased the levels of IGF-1, PDGF, and VEGF gene expression in poisoned rats. Conclusions: Based on the results of this study, resistance training and berberine supplementation have significant effects on reducing the harmful effects of diazinon toxin (P < 0.05) and increasing IGF-1, PDGF, and VEGF gene expression in poisoned rats.

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“…Results of the present study revealed increased VEGF levels for sprint-endurance training groups without supplementation, which are consistent with the results of some studies 23,25,28 while different from the results of some other studies. 8,29 The specific training method applied in this study could account for such contradictory results. In addition to the aforesaid training method, different timings of the blood sample collection may also account for the contradictory results of the present study and the study conducted by Thorell et al 17 In fact, in the latter study blood sampling was performed 1 hour after exercise, whereas in the present study blood samples were collected 24 hours after the last training session and in the morning on an empty stomach.…”

Section: Discussionmentioning

confidence: 99%

“…8,27 In addition, Gu et al reported reduced serum VEGF concentration after exercise. 29 Several studies have also contemplated the effect of free radicals on angiogenesis. Zhao et al, analyzing the effect of reactive oxygen species (ROS) on cardiac angiogenesis following myocardial infarction (MI), found that angiogenesis occurs in the first week of MI, developed in spatio-temporal symmetry with ROS.…”

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confidence: 99%