Exercise-Induced Anaphylactic Syndromes

Casale, Thomas B.

doi:10.1001/jama.1986.03370150091034

Cited by 61 publications

(5 citation statements)

References 16 publications

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“…Exercise is associated with significant alterations of endocrine (Irvine 1982) and metabolic parameters (Snow 1979). Disorders specifically linked with onset of exercise have been described in man (Casale et al 1986) and horses (Logan et al 1992). The potential role for a physiological lowering of the threshold for photic headshaking with exercise remains to be investigated.…”

Section: Discussionmentioning

confidence: 99%

Photic headshaking in the horse: 7 cases

Madigan

Kortz

Murphy

et al. 1995

Equine Veterinary Journal

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Summary Seven horses with headshaking are described. No physical abnormalities were detected in any of the cases. Six of these horses had onset of clinical signs in the spring. The role of light was assessed by application of a blindfold or dark grey lens to the eyes, covering the eyes with a face mask and observing the horse in total darkness outdoors. Cessation of headshaking was observed with blindfolding (5/5 horses), night darkness outdoors (4/4 horses) and use of grey lenses (2/3 horses). Outdoor behaviour suggested efforts to avoid light in 4/4 cases. The photic sneeze in man is suggested as a putative mechanism for equine headshaking. Five of 7 horses had improvement with cyproheptadine treatment (0.3 mg/kg bwt b.i.d.). Headshaking developed within 2 calendar weeks of the same date for 3 consecutive years in one horse. Neuropharmacological alterations associated with photoperiod mechanisms leading to optic trigeminal summation are suggested as possible reasons for spring onset of headshaking.

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Section: Discussionmentioning

confidence: 99%

Photic headshaking in the horse: 7 cases

Madigan

Kortz

Murphy

et al. 1995

Equine Veterinary Journal

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“…In addition, exercise-induced histamine release has been demonstrated in exercise-induced urticaria and anaphylaxis (8). Moreover, there was a marked increase in the wheal response to compound 48/80 (a cutaneous mast cell secretagogue) and not to histamine after a combination of food and exercise challenge in patients with food-associated exercise-induced urticaria-angioedema (9).…”

Section: Introductionmentioning

confidence: 99%

Increased Releasability of Skin Mast Cells after Exercise in Patients with Exercise-induced Asthma

et al. 2004

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The role of lung mast cells in exercise-induced asthma (EIA) is controversial. To investigate whether the skin mast cell releasability is increased after exercise in EIA, 49 young atopic men with or without asthma took part in a free-running test for 6 min and were given skin prick tests using morphine, a mast cell secretagogue, before and after the exercise. The mean diameters of the wheal induced by morphine in patients with EIA were not significantly different from those in patients without EIA before exercise, although the baseline lung function was significantly lower and the airway hyperresponsiveness, the peripheral blood eosinophil count, and the size of the wheal in response to Dermatophagoides pteronyssinus were significantly higher in patients with EIA. However, the differences of the morphine-induced wheal diameter between patients with EIA and those without EIA became significant at 120 min after exercise (p<0.05), while the responses to histamine were not significantly different. These results suggest that exercise increases the releasability of skin mast cells in EIA patients whose asthma/allergy are relatively severe.

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“…Although EIA used to be reported as a component of severe cholinergic urticaria, 9 it appears to be a distinct entity 10,11 . EIA can be distinguished from cholinergic urticaria by passive heat challenge 11 . After a passive heat challenge that increases core body temperature by more than 0·7 °C, only patients with cholinergic urticaria develop an anaphylactic reaction.…”

Section: Discussionmentioning

confidence: 99%

“…Cholinergic urticaria is associated with sweating 1 . Although EIA used to be reported as a component of severe cholinergic urticaria, 9 it appears to be a distinct entity 10,11 . EIA can be distinguished from cholinergic urticaria by passive heat challenge 11 .…”

Section: Discussionmentioning

confidence: 99%

A case of cold-dependent exercise-induced anaphylaxis

2002

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Exercise-induced anaphylaxis (EIA) is a form of physical urticaria that is induced by exercise. A 16-year-old Japanese boy had a 4-year history of recurrent wealing and dyspnoea after physical exercise such as jogging, playing handball or riding a bicycle in winter. The episodes were not associated with ingestion of foods including wheat or soya bean. A provocation test, with 15 min of exercise and 2 min of cold stimulation immediately before or immediately after the exercise, elicited a weal that was localized to the test area. A challenge test with ingestion of boiled soya beans and exercise did not elicit a weal. Therefore, in this case, cold exposure, but not food ingestion, was essential for inducing EIA. Cold-dependent EIA is different from cold urticaria, food-dependent EIA, cholinergic urticaria and cold-induced cholinergic urticaria, and may be a distinct entity.

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Exercise-Induced Anaphylactic Syndromes

Cited by 61 publications

References 16 publications

Photic headshaking in the horse: 7 cases

Photic headshaking in the horse: 7 cases

Increased Releasability of Skin Mast Cells after Exercise in Patients with Exercise-induced Asthma

A case of cold-dependent exercise-induced anaphylaxis

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