Exercise-induced changes in cardiac gene expression and its relation to spatial maze performance

Schweitzer, Natalie B.; Alessio, Helaine M.; Berry, Stephen D.; Roeske, Kirk; Hagerman, Ann

doi:10.1016/j.neuint.2005.08.006

Cited by 37 publications

(32 citation statements)

References 28 publications

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“…A large prospective study concluded that regular exercise in AD patients delays the onset of dementia and AD (Larson et al, 2006). This human data is supported by animal research demonstrating that exercise can facilitate learning in AD mouse models (O'Callaghan et al, 2007;Radak et al, 2006;Schweitzer et al, 2006;van Praag et al, 2005;Vaynman et al, 2004). Previous work from our laboratory explored the effects of exercise on cognition using the TgCRND8 mouse model of AD (Adlard et al, 2005).…”

Section: Introductionmentioning

confidence: 75%

“…We propose that exercise exerts its beneficial effects on cognition in the aged Tg2576 runners in part by altering the expression level of inflammatory molecules; including increasing levels of the chemokines CXCL1 (Groα) and CXCL12 (SDF1). In support of this, exercise has been repeatedly shown to exert positive effects on cognitive function in humans (Colcombe and Kramer, 2003;Heyn et al, 2004;Kramer et al, 1999;Weuve et al, 2004;Young, 1979) and enhance learning/memory in mice (Fordyce and Wehner, 1993;Nichol et al, 2007;O'Callaghan et al, 2007;Schweitzer et al, 2006;van Praag et al, 2005;Vaynman et al, 2004). Studies in the periphery have documented leukocytosis and changes in circulating cytokines including TNFα, IL1, IL6, IL10 with physical exercise (Bruunsgaard, 2005;Jonsdottir et al, 2000;Lancaster et al, 2004;Ostrowski et al, 1998a;Ostrowski et al, 1998b;Pedersen et al, 1997;Rohde et al, 1997).…”

Section: Discussionmentioning

confidence: 96%

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Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition

Parachikova

Nichol

Cotman

2008

Neurobiology of Disease

171

113

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Exercise is a treatment paradigm that can ameliorate cognitive dysfunction in Alzheimer disease (AD) and AD mouse models. Since exercise is also known to alter the peripheral immune response, one potential mechanism for the cognitive improvement following exercise may be by modulating the inflammatory repertoire in the central nervous system. We investigated the effects of voluntary exercise in the Tg2576 mouse model of AD at a time-point at which pathology has already developed. Inflammatory mRNA markers are increased in sedentary Tg2576 mice versus non-transgenic controls. We demonstrate that short-term voluntary wheel running improved spatial learning in aged transgenic mice as compared to sedentary Tg2576 controls. Inflammatory profiles of the Tg2576 and non-transgenic mice were different following exercise with the non-transgenic mice showing a broader response as compared to the Tg2576. Notably, exercising Tg2576 exhibited increases in a few markers including CXCL1 and CXCL12, two chemokines that may affect cognition.

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Section: Introductionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 96%

Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition

Parachikova

Nichol

Cotman

2008

Neurobiology of Disease

171

113

View full text Add to dashboard Cite

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“…Numerous studies on rodents suggested that exercise improves acquisition and retention in memory-dependent tasks such as the radial arm maze, 79 the Morris water maze, 80,81 passive avoidance, 82 and object recognition. 83 There is no clear explanation for this relation between physical activity and brain function.…”

Section: Basic Researchmentioning

confidence: 99%

Healthy Brain Aging: Role of Exercise and Physical Activity

Rolland¹,

Kan²,

Vellas³

2010

Clinics in Geriatric Medicine

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“…Research shows that exercise can improve memory in different behavioral tasks (Samorajski et al 1985;Anderson et al 2000;Radak et al 2006;Chen et al 2008). For example, exercise could facilitate memory in various hippocampus-dependent tasks, such as passive and active avoidance (Radak et al 2006;Greenwood et al 2007;Saadipour et al 2009), radial arm maze (Schweitzer et al 2006), radial arm water maze (Nichol et al 2007;Khabour et al 2010), novel object recognition (O'Callaghan et al 2007), Y maze ( Van der Borght et al 2007) and Morris water maze (Vaynman et al 2004;Van Praag et al 2005). Hence, physical activity could enhance memory and cognitive function via different mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Effect of forced exercise and exercise withdrawal on memory, serum and hippocampal corticosterone levels in rats

et al. 2015

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Evidence suggests that there are positive effects of exercise on learning and memory. Moreover, some studies have demonstrated that forced exercise plays the role of a stressor. This study was aimed at investigating the effects of different timing of exercise and exercise withdrawal on memory, and serum and hippocampal corticosterone (CORT) levels. Wistar rats were randomly divided into five groups: control, sham, exercise-rest (exercise withdrawal), rest-exercise (exercised group), and exercise-exercise (continuous exercise). Rats were forced to run on a treadmill for 1 h/day at a speed 20-21-m/min. Memory function was evaluated by the passive avoidance test in different intervals (1, 7 and 21 days) after foot shock. Findings showed that after the exercise withdrawal, short-term and mid-term memories, had significant enhancement compared to the control group, while the long-term memory did not present this result. In addition, the serum and hippocampal CORT levels were at the basal levels after the rest period in the exercise-rest group. In the rest-exercise group, exercise improved mid- and long-term memories, whereas continuous exercise improved all types short-, mid- and long-term memories, particularly the mid-term memory. Twenty-one and forty-two days of exercise significantly decreased the serum and hippocampal CORT levels. It seems that exercise for at least 21 days with no rest could affect biochemical factors in the brain. Also, regular continuous exercise plays an important role in memory function. Hence, the duration and withdraw of exercise are important factors for the neurobiological aspects of the memory responses.

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Exercise-induced changes in cardiac gene expression and its relation to spatial maze performance

Cited by 37 publications

References 28 publications

Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition

Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition

Healthy Brain Aging: Role of Exercise and Physical Activity

Effect of forced exercise and exercise withdrawal on memory, serum and hippocampal corticosterone levels in rats

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