Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players

Amin, Mohamed N.; El‐Mowafy, Mohammed; Mobark, Ali; Abass, Naglaa; Elgaml, Abdelaziz

doi:10.1016/j.sjbs.2020.10.065

Cited by 9 publications

(8 citation statements)

References 51 publications

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“…Several studies have investigated the responses of pro-inflammatory cytokines, inflammatory cytokines and inflammatory markers to different exercise intensities and modalities, and these studies report distinct results [ 11 , 13 , 16 , 17 , 33 , 34 ]. The conflicting results from previous literature may arise from differences in exercise intensities, exercise modalities, VO2 max capacities, the timing of blood sampling and biological variations.…”

Section: Discussionmentioning

confidence: 99%

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Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude

Baygutalp

Buzdağlı

Ozan

et al. 2021

BMC Sports Sci Med Rehabil

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Background This study aims to determine and compare the effects of exercise modalities with different intensities on the secretion of key inflammation and hypoxia markers in amateur athletes. Methods Twenty-three athletes with a mean age of 20.1 years, living at low altitude (1850 m) participated in this study. The participants' maximal oxygen consumption values (VO2 max) were determined with an incremental cycle exercise test as 54.15 ± 6.14 mL kg min−1. Athletes performed four protocols: at rest, 50% VO2 max, 75% VO2 max and 100% VO2 max (until exhaustion) with one-week intervals. 50% VO2 max, 75% VO2 max sessions were performed continuously for 30 min on a bicycle ergometer and 100% VO2 max session was performed by cycling until exhaustion. Blood samples were obtained at rest and immediately after each exercise session. Serum tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), interleukin-10 (IL-10), and hypoxia inducible factor-1 alpha (HIF-1α) levels were measured. Results There were significant differences in serum TNF-α levels in 75% VO2 max and 100% VO2 max sessions (489.03 ± 368.37 and 472.70 ± 365.21 ng/L, respectively) compared to rest conditions (331.65 ± 293.52 ng/L). Serum CRP levels of 50% VO2 max and 75% VO2 max sessions (1.19 ± 0.50; 1.07 ± 0.52 mg/L) were significantly higher than the rest condition (0.74 ± 0.35 mg/L). There were significant differences in serum IL-10 levels of rest condition and 50% VO2 max; 50% VO2 max, and 100% VO2 max sessions (328.09 ± 128.87; 446.36 ± 142.84; 347.44 ± 135.69; 324.88 ± 168.06 pg/mL). Serum HIF-1α levels were significantly higher in 75% VO2 max session compared to rest (1.26 ± 0.16; 1.08 ± 0.19 ng/mL) (P < 0.05 for all comparisons). Conclusions Both inflammatory and anti-inflammatory pathway is induced on different exercise intensities. Exercise protocols performed until exhaustion may lead to activation of inflammatory pathways and hypoxia-induced damage.

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Section: Discussionmentioning

confidence: 99%

“…The TNF-α level is decreased by moderate exercise (exercise intensity HRmax 60–70%) [ 33 ], and mRNA expression of TNF-α is known to be slightly elevated in skeletal muscle by endurance exercise [ 35 ]. In the previous study, a gradient increment was observed in serum TNF-α levels as exercise intensity increases.…”

Section: Discussionmentioning

confidence: 99%

Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude

Baygutalp

Buzdağlı

Ozan

et al. 2021

BMC Sports Sci Med Rehabil

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“…The researchers discovered that individuals who engaged in high-intensity aerobic and resistive exercises experienced reduced levels of TNF-α and IL-1β. Amin et al investigated 18 Egyptian male handball players, comparing their serum IL-6 and TNF-α before and after intermediate-to-high intensity exercise [ 39 ]. Post-exercise downregulation of both cytokines was observed, coupled with an increase in the white count level.…”

Section: Discussionmentioning

confidence: 99%

Enhanced serum levels of tumor necrosis factor-α, interleukin-1β, and -6 in sarcopenia: alleviation through exercise and nutrition intervention

Chang,

Wu,

Chen

et al. 2023

Aging

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Background: Limited research has been conducted on the post-intervention inflammatory status in sarcopenic patients, despite previous studies revealing elevated pro-inflammatory markers. This study aimed to investigate the potential elevation of specific pro-inflammatory cytokines in sarcopenic patients and evaluate the effects of exercise and nutritional support interventions on these cytokine levels. Methods: In this post-hoc analysis of a randomized controlled trial (RCT), 57 individuals with sarcopenia from the RCT and 57 non-sarcopenic participants from the same geriatric community cohort that did not participate in the RCT were enrolled. Grip strength and body composition measurements were recorded. Tumor necrotizing factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-15 levels were assessed at baseline for both groups and after a 12-week intervention consisting of resistive exercise and supplementation with branched-chain amino acids, calcium, and vitamin D3 in the patients with sarcopenia. Results: The sarcopenic group demonstrated significantly lower body weight, body mass index, grip strength, and skeletal muscle mass index. Moreover, sarcopenic patients exhibited higher levels of TNF-α ( p =0.007), IL-1β ( p <0.001), and IL-6 ( p <0.001), while no significant difference was observed in IL-15 ( p =0.345) between participants with and those without sarcopenia. Following the intervention, the sarcopenic group experienced significant improvements in grip strength and skeletal muscle mass index with a notable reduction in TNF-α ( p =0.003), IL-1β ( p =0.012) and IL-6 ( p =0.001) levels. Conclusions: Sarcopenic patients exhibit elevated levels of TNF-α, IL-1β, and IL-6, which declined after nutrition support and exercise interventions. However, further research is necessary to evaluate the long-term impact of these interventions on cytokine levels.

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“…Despite the fact they are positively correlated with each other, some inflammatory biomarkers are negatively associated with the WBC and platelet count, which, in contrast, are elevated after training [ 72 ]. Therefore, in addition to these biomarkers, a CBC/diff may add certain value to the diagnosis approach.…”

Section: Interleukins and Tumor Necrosis Factor: More Than Classical Inflammatory Biomarkersmentioning

confidence: 99%

Beyond the Finish Line: The Impact and Dynamics of Biomarkers in Physical Exercise—A Narrative Review

Costache

Miftode

et al. 2021

JCM

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The research of biomarkers continues to emerge as a developing academic field which is attracting substantial interest. The study of biomarkers proves to be useful in developing and implementing new screening methods for a wide variety of diseases including in the sports area, whether for leisure activities or professional sports. Novel research has brought into question the immune system and the limitations it may impose on sports practicing. As the well-being of athletes is a priority, the state of their immune function offers valuable information regarding their health status and their ability to continue training. The assessment of various biomarkers may contribute to a more accurate risk stratification and subsequent prevention of some invalidating or even fatal pathologies such as the sudden cardiac death. Therefore, we have reviewed several studies that included sports-related pathology or specific morphofunctional alterations for which some immune biomarkers may represent an expression of the underlying mechanism. These include the defensins, immunoglobulin A (IgA), interleukin-6 (IL-6), the tumoral necrosis factor α (TNF-α), and the white blood cells (WBC) count. Similarly, also of significant interest are various endocrine biomarkers, such as cortisol and testosterone, as well as anabolic or catabolic markers, respectively. Literature data highlight that these values are greatly influenced not only by the duration, but also by the intensity of the physical exercise; moderate training sessions actually enhance the immune function of the body, while a significant increase in both duration and intensity of sports activity acts as a deleterious factor. Therefore, in this paper we aim to highlight the importance of biomarkers’ evaluation in connection with sports activities and a subsequent more adequate approach towards personalized training regimens.

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Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players

Cited by 9 publications

References 51 publications

Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude

Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude

Enhanced serum levels of tumor necrosis factor-α, interleukin-1β, and -6 in sarcopenia: alleviation through exercise and nutrition intervention

Beyond the Finish Line: The Impact and Dynamics of Biomarkers in Physical Exercise—A Narrative Review

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