Exercise-induced hyperkalemia in hypothyroid dogs

Schaafsma, I. A.; Emst, Maarten G. van; Kooistra, Hans S.; Verkleij, C.B.; Peeters, Marijke E.; Boer, P. de; Rijnberk, A.; Everts, M. E.

doi:10.1016/s0739-7240(01)00130-8

Cited by 16 publications

(10 citation statements)

References 23 publications

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“…In hypothyroid Beagles subjected to the same exercise protocol as in the present study a peak in plasma K + was seen immediately after exercise [2]. This plasma K + peak was not observed in dogs with PDH, which may be explained in two ways.…”

Section: Treadmill Exercise Testsupporting

confidence: 44%

“…This was essentially the same for the exercise-mediated plasma changes found in the present study. Although changes in plasma pCO 2 were not significantly different in dogs with PDH before and after hypophysectomy, calculation with exact values revealed that the decreased pCO 2 in dogs with PDH led to decreased plasma K + concentration thereby flattening the plasma K + peak. The more pronounced respiratory alkalosis during and after exercise in dogs with PDH may be caused by enhanced panting [42] due to an enlarged abdomen, or in response to glucocorticoid-mediated body heat production [43].…”

Section: Treadmill Exercise Testmentioning

confidence: 74%

“…The justification to apply this method to quantify the Na + -, K + pump content as an estimate of Na + , K + -ATPase activity in dog skeletal muscle is based on the methodological studies reviewed in [26] and its previous validation on muscle tissue of hypothyroid dogs [2]. During the measurement biopsies were kept in baskets with a gas inlet attached to the bottom allowing continuous gassing with air to ensure agitation.…”

Section: [ 3 H]-ouabain Bindingmentioning

confidence: 99%

“…Exercise consisted of a 5 min-walk on a treadmill at a speed of 4.5 km/h. Prior to the exercise test, all dogs were familiarized with the treadmill [2]. At 2 and 0 min before exercise, and 0, 2 and 10 min after exercise blood samples were taken from the jugular vein and collected in tubes preheparinized with 60 IU dry electrolyte balanced lithium/sodium heparin (Radiometer Medical A/S, Copenhagen, Denmark).…”

Section: Exercise Testmentioning

confidence: 99%

“…In contrast studies in humans give equivocal results, and for example may even show an increase in free T 4 in patients with Cushing disease, followed by a fall after surgery [34]. As thyroid hormones are important regulators of Na + , K + -ATPase content in skeletal muscle [2][3][4][5][6], the possibly stimulating effect of corticosteroids may be overruled by the chronically low thyroid hormone concentrations in dogs with PDH, ultimately resulting in decreased Na + , K + -ATPase contents. Similarly, because hypophysectomy and hormone replacement therapy was associated with normalization of plasma T 4 concentration, this may have contributed to restoration of Na + , K + -ATPase content.…”

Section: Hormonal Regulation Of Na + K + -Atpase Contentmentioning

confidence: 99%

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Na+, K+-ATPase content in skeletal muscle of dogs with pituitary-dependent hyperadrenocorticism

Schotanus

Meij

Vos

et al. 2006

Domestic Animal Endocrinology

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Several hormones regulate Na + , K + -ATPase content in the muscle cell membrane, which is essential for maintaining muscle cell excitability. Chronic glucocorticoid excess is associated with muscle weakness and reduced endurance. We hypothesized that chronic glucocorticoid excess affects Na + , K + -ATPase content in canine skeletal muscle, and contributes to reduced endurance and muscle weakness associated with pituitary-dependent hyperadrenocorticism (PDH) in dogs. Therefore, Na + , K + -ATPase content in skeletal muscle was evaluated before and after hypophysectomy and hormone replacement (cortisone and l-thyroxin) in dogs with PDH (n = 13), and in healthy controls (n = 6). In addition, baseline and exercise-induced changes in plasma electrolyte concentrations and acid-base balance were evaluated before and after hypophysectomy in dogs with PDH. Na + , K + -ATPase content of gluteal muscle in dogs with PDH was significantly lower than in control dogs (201 ± 13 pmol/g versus 260 ± 8 pmol/g wet weight; P < 0.01). Similar differences were found in palatine muscle. After hypophysectomy and on hormone replacement, Na + , K + -ATPase was increased (234 ± 7 pmol/g wet weight). Both plasma pH and base excess in dogs with PDH (7.44 ± 0.01; 1.7 ± 0.6 mmol/l, respectively) were significantly higher (P < 0.05) than after hypophysectomy and hormone replacement (7.41 ± 0.01; −0.2 ± 0.4 mmol/l, respectively). Exercise induced respiratory alkalosis, but did not result in hyperkalemia in dogs with PDH. In conclusion, chronic glucocorticoid excess in dogs with PDH is associated with decreased Na + , K + -ATPase content in skeletal muscle. This may contribute to reduce endurance in canine PDH, although dogs with PDH did not exhibit exercise-induced hyper- * Corresponding author.

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Section: Treadmill Exercise Testsupporting

confidence: 44%