Exercise‐induced modulation of neuroinflammation in ageing

Barad, Zsuzsanna; Augusto, Joana; Kelly, Aine Marie

doi:10.1113/jp282894

Cited by 10 publications

(3 citation statements)

References 138 publications

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“…It is possible that exercise also reduces gliosis and glial proliferation [103]. Moreover, via its action on CNS glial cells, regular aerobic exercise has been shown to provide an adaptive advantage against perturbations to homeostasis, such as immunological challenge or ageing in animal models [174]. A systematic review and meta-analysis involving 13 RCTs and 514 participants, revealed that physical activity had positive effects on decreasing TNF-α and CRP (pro-inflammatory), while significantly improving BDNF and IGF-1 (neuroprotective) [175].…”

Section: Specifically Targeting Neuroinflammation To Improve Sleep An...mentioning

confidence: 99%

The Putative Role of Neuroinflammation in the Interaction between Traumatic Brain Injuries, Sleep, Pain and Other Neuropsychiatric Outcomes: A State-of-the-Art Review

Babiloni

Baril

Charlebois-Plante

et al. 2023

JCM

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Sleep disturbances are widely prevalent following a traumatic brain injury (TBI) and have the potential to contribute to numerous post-traumatic physiological, psychological, and cognitive difficulties developing chronically, including chronic pain. An important pathophysiological mechanism involved in the recovery of TBI is neuroinflammation, which leads to many downstream consequences. While neuroinflammation is a process that can be both beneficial and detrimental to individuals’ recovery after sustaining a TBI, recent evidence suggests that neuroinflammation may worsen outcomes in traumatically injured patients, as well as exacerbate the deleterious consequences of sleep disturbances. Additionally, a bidirectional relationship between neuroinflammation and sleep has been described, where neuroinflammation plays a role in sleep regulation and, in turn, poor sleep promotes neuroinflammation. Given the complexity of this interplay, this review aims to clarify the role of neuroinflammation in the relationship between sleep and TBI, with an emphasis on long-term outcomes such as pain, mood disorders, cognitive dysfunctions, and elevated risk of Alzheimer’s disease and dementia. In addition, some management strategies and novel treatment targeting sleep and neuroinflammation will be discussed in order to establish an effective approach to mitigate long-term outcomes after TBI.

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Section: Specifically Targeting Neuroinflammation To Improve Sleep An...mentioning

confidence: 99%

The Putative Role of Neuroinflammation in the Interaction between Traumatic Brain Injuries, Sleep, Pain and Other Neuropsychiatric Outcomes: A State-of-the-Art Review

Babiloni

Baril

Charlebois-Plante

et al. 2023

JCM

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show abstract

“…Exercise has also been shown to enhance expression of neurotrophins, such as brain derived neurotrophic factor (BDNF), that regulate neurogenesis, neuronal function and survival ( 27 ). Finally, exercise may also modulate glia cell phenotype and function ( 28 ).…”

Section: Exercise Intervention Studies Are Conducted Late In People W...mentioning

confidence: 99%

Multiple sclerosis and exercise—A disease-modifying intervention of mice or men?

Martin,

Schneider

2023

Front. Neurol.

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Research suggests that physical exercise can promote an anti-inflammatory and neuroprotective state. If so, increasing or optimizing exercise could be considered a 'disease-modifying intervention' in neuroinflammatory diseases, such as multiple sclerosis (MS). Exercise intervention studies conducted in animal models of MS are promising. Various aerobic and strength training regimes have been shown to delay disease onset and to reduce both the clinical and pathological disease severity in mice. However, fundamental differences between the physiology of animals and humans, the disease states studied, and the timing of exercise intervention are significant. In animal models of MS, most exercise interventions begin before disease initiation and before any clinical sign of disease. In contrast, studies in humans recruit participants on average nearly a decade after diagnosis and often once disability is established. If, as is thought to be the case for disease-modifying treatments, the immunomodulatory effect of exercise decreases with advancing disease duration, current studies may therefore fail to detect the true disease-modifying potential. Clinical studies in early disease cohorts are needed to determine the role of exercise as a disease-modifying intervention for people with MS.

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“…In the paper 'Exercise-induced modulation of neuroinflammation in ageing' , Barad, Augusto and Kelly discuss age-related disequilibrium within the central nervous system (CNS) and the critical role that inter-organ communication may play in CNS dysfunction, particularly highlighting the role of immune cells (Barad et al, 2023). They assess the evidence showing that endurance exercise can induce adaptive benefits to neuroimmune communications that can help ameliorate homeostatic challenges caused by immunological stresses or ageing.…”

mentioning

confidence: 99%

Can exercise prevent the age‐related decline in adaptive homeostasis? Evidence across organisms and tissues

Hamilton

Selman

2023

The Journal of Physiology

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Exercise‐induced modulation of neuroinflammation in ageing

Abstract: support-information-section).

Cited by 10 publications

References 138 publications

The Putative Role of Neuroinflammation in the Interaction between Traumatic Brain Injuries, Sleep, Pain and Other Neuropsychiatric Outcomes: A State-of-the-Art Review

The Putative Role of Neuroinflammation in the Interaction between Traumatic Brain Injuries, Sleep, Pain and Other Neuropsychiatric Outcomes: A State-of-the-Art Review

Multiple sclerosis and exercise—A disease-modifying intervention of mice or men?

Can exercise prevent the age‐related decline in adaptive homeostasis? Evidence across organisms and tissues

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