Exercise-induced neutrophil activation in claudicants: a physiological or pathological response to exhaustive exercise?

Turton, Philip; Spark, J.I.; Mercer, K. G.; Berridge, David; Kent, P.; Kester, R. C.; Scott, D. J. A.

doi:10.1016/s1078-5884(98)80219-0

Cited by 22 publications

(16 citation statements)

References 30 publications

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“…The time course of this response merits further investigation as PLA and PNA levels remained high even after 60 min of rest. Given that the pattern of exercise‐induced platelet P‐selectin expression was not significantly different between patients with claudication and controls, the protracted increase in PLA and PNA levels is consistent with evidence in the literature that leucocytes are stimulated by exercise in patients with claudication23–25.…”

Section: Discussionsupporting

confidence: 87%

“…An exercise‐induced inflammatory response was demonstrated both in patients with claudication and in control subjects. This has been shown in previous studies, although often to a greater degree in patients with claudication23–25. The present study suggested that platelet fibrinogen binding and P‐selectin expression were not increased after exercise in patients with claudication any more than the physiological response observed in healthy people of a similar age.…”

Section: Discussionsupporting

confidence: 80%

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Effects of warm-up on exercise capacity, platelet activation and platelet–leucocyte aggregation in patients with claudication

Pasupathy

Naseem

Homer‐Vanniasinkam

2005

Journal of British Surgery

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 80%

Effects of warm-up on exercise capacity, platelet activation and platelet–leucocyte aggregation in patients with claudication

Pasupathy

Naseem

Homer‐Vanniasinkam

2005

Journal of British Surgery

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“…Exercise has been described to produce the secretion of several neutrophil granule proteins in blood (Camus et al 1998;Turton et al 1998;Walsh et al 2000). These proteins are present either in individual types of granules (the specific granules that contain lactoferrin and elastase and the azurophilic granules that contain MPO) or in granules of both types (lysozyme).…”

Section: Discussionmentioning

confidence: 99%

Effect of exercise to exhaustion on myeloperoxidase and lysozyme release from blood neutrophils

et al. 2003

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Exercise sessions (swimming in rats and treadmill running in humans) resulted in stimulation of neutrophil degranulation in the experiments with animals and in the human study. Myeloperoxidase (MPO) (+67%) and lysozyme (+51%) quantities in the plasma of rats increased significantly immediately after exercise. The blood plasma lysozyme concentration was increased by 41% at the 6th min of treadmill exercise in athletes. The blood concentrations of neutrophil proteins normalized both in humans and animals at rest. The neutrophil protein concentrations in blood increased in parallel with the decrease of their level in leukocytes. The neutrophil capacity for an oxidative burst was not changed by the exercise, but decreased for 3-6 h in the post-exercise period. Such dynamics of the oxidative burst activity suggest a lack of association between this parameter and the degranulation process. The neutrophil proteins that appear in blood during degranulation can be involved in enhancing the bactericidal potency of blood, the activation of granulopoiesis, neutrophil efflux from bone marrow, and the conditioning of blood endothelium for leukocyte extravasation.

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“…Exercise-induced muscle ischemia in patients with IC evokes a potent increase in local and systemic markers of inflammation and oxidative stress (33,47,56), as well as an acute impairment in vascular reactivity (48). Repeated exposure to cycles of ischemiareoxygenation injury during ambulatory activity in these patients is thought to contribute, among others, to the development of skeletal muscle abnormalities, including fibrosis and mitochondrial dysfunction (39).…”

Section: Effects Of Sildenafil On Muscle Oxygenationmentioning

confidence: 99%

Sildenafil improves skeletal muscle oxygenation during exercise in men with intermittent claudication

Roseguini

Hirai

Alencar

et al. 2014

American Journal of Physiology-Regulatory, Integrative and Comp

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Endothelial dysfunction caused by defective nitric oxide (NO) signaling plays a pivotal role in the pathogenesis of intermittent claudication (IC). In the present study, we evaluated the acute effects of sildenafil, a phosphodiesterase type 5 inhibitor that acts by prolonging NO-mediated cGMP signaling in vascular smooth muscle, on blood pressure (BP), skeletal muscle oxygenation, and walking tolerance in patients with IC. A randomized, double-blind, crossover study was conducted in which 12 men with stable IC received two consecutive doses of 50 mg of sildenafil or matching placebo and underwent a symptom-limited exercise test on the treadmill. Changes in gastrocnemius deoxy-hemoglobin by near-infrared spectroscopy estimated peripheral muscle O2 delivery-to-utilization matching. Systolic BP was significantly lower during the sildenafil trial relative to placebo during supine rest (∼15 mmHg), submaximal exercise (∼14 mmHg), and throughout recovery (∼18 mmHg) (P < 0.05). Diastolic BP was also lower after sildenafil during upright rest (∼6 mmHg) and during recovery from exercise (∼7 mmHg) (P < 0.05). Gastrocnemius deoxygenation was consistently reduced during submaximal exercise (∼41%) and at peak exercise (∼34%) following sildenafil compared with placebo (P < 0.05). However, pain-free walking time (placebo: 335 ± 42 s vs. sildenafil: 294 ± 35 s) and maximal walking time (placebo: 701 ± 58 s vs. sildenafil: 716 ± 62 s) did not differ between trials. Acute administration of sildenafil lowers BP and improves skeletal muscle oxygenation during exercise but does not enhance walking tolerance in patients with IC. Whether the beneficial effects of sildenafil on muscle oxygenation can be sustained over time and translated into positive clinical outcomes deserve further consideration in this patient population.

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Exercise-induced neutrophil activation in claudicants: a physiological or pathological response to exhaustive exercise?

Abstract: The inflammatory response associated with exercise in claudicants is not simply a physiological response to exhaustive exercise.

Cited by 22 publications

References 30 publications

Effects of warm-up on exercise capacity, platelet activation and platelet–leucocyte aggregation in patients with claudication

Effects of warm-up on exercise capacity, platelet activation and platelet–leucocyte aggregation in patients with claudication

Effect of exercise to exhaustion on myeloperoxidase and lysozyme release from blood neutrophils

Sildenafil improves skeletal muscle oxygenation during exercise in men with intermittent claudication

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