Exercise-induced proteinuria in children and adolescents with Type 1 (insulin dependent) diabetes

Abstract

The urinary excretion excretion of albumin and Beta2-microglobulin was measured by radioimmunoassay in 64 children and adolescents with Type 1 (insulin dependent) diabetes and in 68 non-diabetic subjects aged from 9 to 19 years. At rest the albumin excretion of te diabetic subjects did not differ from that of te non-diabetic children and adolescents but during exercise the albumin excretion was significantly higher in children and adolescents with Type 1 diabetes (p less than 0.02). the excretion rate of Beta2-microglobulin in diabetic subjects did not differ from that of the healthy subjects. Both at rest and during exercise the albumin excretion rate was highest in those diabetics with poorest metabolic control of their disease.

Postexercise albuminuria in children with different duration of type-1 diabetes mellitus

“…An albumin excretion in the controls during exercise was not expected because of the moderate workload of our protocol. Nearly all diabetic children had a normal AER at rest; these data confirm the results of previous studies in diabetic children [10][11][12]. In our trial, the duration of diabetes did not correlate with albuminuria at rest.…”

“…In our trial, the duration of diabetes did not correlate with albuminuria at rest. The close correlation of exercise-induced microalbuminuria and disease duration confirms the results of Huttunen et al [12] in children and adolescents, but are at variance with the results of Mogensen et al [2] in young adults. The differences can be explained by different study groups, exercise regimes, and urine sampling periods after exercise.…”

The Role of Physical Exercise on Lipid Peroxidation in Diabetic Complications

“…In diabetes mellitus, the kidneys are more sensitive to the haemodynamic exercise stress [122]. Under exercise, patients with Type 1 diabetes show a partial depletion of negative charges on the glomerular capillary wall [126] that permits the increase of urinary albumin excretion [127]. Reports indicate that urinary albumin excretion increases after exercise, without correlation with glycaemic control, renal function, disease evolution or resting urinary albumin excretion [128,129].…”

“…Reports indicate that urinary albumin excretion increases after exercise, without correlation with glycaemic control, renal function, disease evolution or resting urinary albumin excretion [128,129]. In contrast, postexercise albuminuria has been found to be associated with HbA1c [127,129].…”

Exercise-induced proteinuria in diabetic children

“…Dear Sir, The November 1981 issue of Diabetologia contained an article on exercise-induced proteinuria in children with Type I (insulin-dependent) diabetes [1]. In view of the results of studies on exercise proteinuria obtained in our laboratory, it would seem likely that the use of a radioimmunoassay as a means of estimating glomerular permeability in early diabetes may be providing correct, but less than optimal, information.…”