Exercise‐induced release of pancreatic polypeptide and its inhibition by propranolol: evidence for adrenergic stimulation

Feurle, Gerhard E.; Wirth, Alfred; Diehm, Curt; Lorenzen, M.; Schlierf, G.

doi:10.1111/j.1365-2362.1980.tb00028.x

Cited by 25 publications

(14 citation statements)

References 12 publications

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“…In general, adequate cholin ergic tone is almost indispensible for the se cretory activity of the PP cell: not only stim ulation of PP release by mechanisms that involve activation of the vagal nerves (e.g. sham feeding, insulin hypoglycemia) is atro pine sensitive [9,[11][12][13], but also the re sponse to food [7], histamine [24], gastroin testinal hormones [25,26], and adrenergic stimulation [27], and this strong cholinergic activity is also necessary under in vitro con ditions [9,28], Recently, it has been reported that adren ergic mechanisms contribute to the rnodula-tion of PP secretion; PP levels increased dur ing exercise [17,18,29] and p-sympathomimetics [30], The stimulatory action of cate cholamines is preserved in vitro [31]. It has been shown by Kronborg et al [32] and Christensen and Stadil [33] that stimulation of gastrin release during insulin hypoglyce mia involves adrenergic pathways.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Polypeptide and Gastrin Release during Sham Feeding in Man

Koop¹,

Arnold²,

Creutzfeldt³

1984

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During modified sham feeding (MSF) the role of endogenous gastric acid secretion and the influences of the autonomic nervous system on the release of pancreatic polypeptide (PP) and gastrin have been studied in 12 healthy subjects (aged 24–38 years). Sham feeding was performed without pretreatment (control) and after pretreatment with 400 mg cimetidine, 80 mg propranolol (both given orally) or 1 mg atropine administered subcutaneously 60 min prior to sham feeding. MSF induced a significant increase (about 100%) in PP release. Its early peak was reduced by pretreatment with propranolol whereas cimetidine had no effect. Atropine completely abolished the PP response. Gastrin release was stimulated by MSF only after prior administration of cimetidine and, to a lesser extent, after atropine pretreatment. It is concluded that: (1) the PP release after stimulation is under strong cholinergic control but is also mediated – particularly in the early phase – by adrenergic mechanisms; (2) endogenously released acid during vagal stimulation plays a minor role in the modulation of PP secretion, but (3) masks gastrin response to MSF.

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Section: Discussionmentioning

confidence: 99%

Pancreatic Polypeptide and Gastrin Release during Sham Feeding in Man

Koop¹,

Arnold²,

Creutzfeldt³

1984

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“…After a basal period of 30 min 11 subjects underwent a physical exercise on a bicycle-ergometer for 15 min, as described previously by Feurle et al [3] with slight modifications. The subjects remained in a horizontal position during the whole test procedure.…”

Section: Physical Exercisementioning

confidence: 99%

Role of circulating catecholamines in the control of pancreatic polypeptide and gastrin release

et al. 1989

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The influence of circulating catecholamines on the release of pancreatic polypeptide (PP) and gastrin was studied in volunteers. Physical exercise increased plasma epinephrine by 374 +/- 123% and plasma norepinephrine by 167 +/- 30%, but plasma PP concentrations remained unchanged during standardized bicycle ergometry. Immediately after cessation of exercise catecholamine levels decreased rapidly, whereas PP concentrations increased by 55%. In a second series, epinephrine infusion (5, 25, and 75 ng.kg-1.min-1) increased epinephrine levels by 38 +/- 12, 331 +/- 69, and 1229 +/- 131%, respectively, whilst norepinephrine was unaffected. Neither during nor after catecholamine infusion PP secretion was affected. Gastrin release increased by a maximum of 85 +/- 38% (at epinephrine 75 ng.kg-1.min-1). It is concluded, that (1) changes in circulating adrenaline do not significantly influence PP secretion in man; (2) the PP increase immediately following physical exercise cannot be attributed to a rapid fall of catecholamine levels; (3) endogenous catecholamines are of minor importance in the control of gastrin secretion.

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“…The radioimmunoassay for PP was performed as published [12], insulin was determined with the RIAgnost insulin, cross-reacting about 5% with proinsulin (Behringwerke, Marburg). As canine PP and insulin were not available, serial dilutions of canine pan creatic extracts were placed in the radioimmunoassay for the respective hormones.…”

Section: Methodsmentioning

confidence: 99%

Dose-Response Study of Somatostatin on Meal-Stimulated Levels of Pancreatic Polypeptide and Insulin in the Dog

Feurle¹,

P²,

Stauder³

et al. 1982

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A dose-response study of the effect of 0.1–5.0 μg kg^-1 h^-1 somatostatin was performed on food-induced rise of pancreatic polypeptide and insulin in 4 dogs. There was a dose-dependent suppression of the release of pancreatic polypeptide and insulin with an ED₅₀of approximately 0.65 and 0.8 μg kg^-1 h^-1, respectively, during the first 45-min period. In the second 45-min period, high doses of somatostatin failed to suppress insulin concentrations whereas, the serum concentrations of pancreatic polypeptide were reduced by a similar degree as in the first 45 min. The differing effects of somatostatin on food-stimulated serum concentrations of insulin and pancreatic polypeptide indicate that somatostatin does not represent a uniform suppressor of pancreatic hormones.

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Exercise‐induced release of pancreatic polypeptide and its inhibition by propranolol: evidence for adrenergic stimulation

Cited by 25 publications

References 12 publications

Pancreatic Polypeptide and Gastrin Release during Sham Feeding in Man

Pancreatic Polypeptide and Gastrin Release during Sham Feeding in Man

Role of circulating catecholamines in the control of pancreatic polypeptide and gastrin release

Dose-Response Study of Somatostatin on Meal-Stimulated Levels of Pancreatic Polypeptide and Insulin in the Dog

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