Exercise Intensity Modulation of Hepatic Lipid Metabolism

Lira, Fábio Santos; Carnevali, Luiz Carlos; Zanchi, Nelo Eidy; Santos, Ronaldo Vt; Lavoie, Jean-Marc; Seelaender, Marília

doi:10.1155/2012/809576

Cited by 38 publications

(42 citation statements)

References 60 publications

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“…A large number of epidemiological and experimental studies found that long-term regular exercise improved their poor lipid structures effectively, so that the risk of cardiovascular disease was significantly reduced (27). The present study also showed that the continuous and intermittent exercises affected the plasma lipid metabolism, decreasing the levels of LDL, TC and TG, while increasing the HDL level, which may be associated with increased lipoprotein lipase activity to release more fatty acids from lipoproteins (28).…”

Section: Discussionsupporting

confidence: 64%

Improvement of thoracic aortic vasoreactivity by continuous and intermittent exercise in high-fat diet-induced obese rats

Liu

Yang

et al. 2015

Biomedical Reports

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Abstract. The aim of the present study was to explore the effects of continuous and intermittent exercise on the thoracic aortic vasoreactivity and free radical metabolism in rats fed with a high-fat diet (HD). Sprague-Dawley (SD) rats were randomly divided into four groups (n=8, each group): Conventional diet (CD), HD, HD with continuous exercise (HCE) and HD with intermittent exercise (HIE). HCE rats swam once/day for 90 min; HIE rats performed swimming exercises 3 times/day, 30 min each time with an interval of 4 h. In these two groups, the exercise was conducted 5 days a week for 8 weeks. Rats in the CD and HD groups were fed without swimming training. At the end of the exercise, all the rats were sacrificed and the blood, thoracic aorta and myocardium were collected immediately. The thoracic aortic vasoreactivity, the plasma total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), superoxide dismutase (SOD), malondialdehyde (MDA) and vascular endothelial nitric oxide synthase (eNOS) gene expression were measured. Compared to the control group, in the HD group the enhanced contractile response of the thoracic aortic rings to noradrenaline (NA) was observed (P<0.01). The levels of TC and LDL (P<0.01) were also increased in serum while the HDL level was reduced without statistical significance. In addition, the MDA content was upregulated in the myocardium, but the SOD level decreased (P<0.01). Furthermore, the expression of vascular eNOS mRNA was reduced (P<0.01). However, following the exercise the contraction of the thoracic aorta vascular rings to NA was reduced in the HCE and HIE groups (P<0.01), and the decreased contractile response was more evident in the HIE group compared to the HCE group (P<0.01). Additionally, in the HCE group the level of TG (P<0.01) was decreased, while the HDL (P<0.01) level was increased. Although the reduction of the TC and LDL level was also observed there was no significant difference compared to the HD group. In the HIE group, the TG, TC and LDL were downregulated while the HDL was enhanced (P<0.01). The TC and LDL levels were decreased more than those of the HCE group; however, there was no significant difference in the TG and HDL levels between these two groups; additionally, in these two exercise groups, the MDA level was decreased in the myocardium (P<0.01) while the SOD level was increased (P<0.01). Furthermore, the expression of eNOS was upregulated (P<0.01), but the increase was much more in the HIE group than that in the HCE group. In conclusion, exercise may attenuate the aggravated contraction induced by NA and improve the activity of the thoracic aorta in obese rats, which may be associated with enhanced antioxidant enzyme activity and reduced free radical generating. Additionally, intermittent exercise is better than the continuous exercise in improving the thoracic aorta vasoreactivity.

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Section: Discussionsupporting

confidence: 64%

Improvement of thoracic aortic vasoreactivity by continuous and intermittent exercise in high-fat diet-induced obese rats

Liu

Yang

et al. 2015

Biomedical Reports

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“…Our group (de Mello et al, 2011;Lira, Carnevali, et al, 2012;Lira, Rosa, et al, 2012) showed reduced inflammatory status after changing their lifestyle in the interdisciplinary program.…”

Section: Discussionmentioning

confidence: 75%

“…In a review, Bouassida et al (2010) concluded that physical training improves fitness levels and affect body composition, which could increase adiponectin levels. In addition, our group has demonstrated that reduced endotoxin levels are also related to the improvement in insulin resistance (Lira, Carnevali, et al, 2012).…”

Section: Discussionmentioning

confidence: 91%

Linear and undulating periodized strength plus aerobic training promote similar benefits and lead to improvement of insulin resistance on obese adolescents

Inoue

Mello²,

Foschini³

et al. 2015

Journal of Diabetes and its Complications

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“…Simultaneously, aerobic exercise can improve lipid metabolism in the CD, particularly intermittent exercises. The experimental results showed that in the HD group, improved blood lipids lead to the decreased levels of LDL, TC and TG, while the HDL level was increased, which may be associated with the increased lipoprotein lipase activity, so that the lipoprotein releases more fatty acids (35). In the CIE group, blood lipids were also improved, which reduced the LDL, TC and TG levels, suggesting that intermittent exercise could improve lipid metabolism in the two diets.…”

Section: Discussionmentioning

confidence: 94%

Intermittent exercise improves the vasoreactivity of the thoracic aorta in rats

Luo

et al. 2016

Biomedical Reports

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Abstract. Vasoreactivity is the most basic and direct indicator to reflect the artery vascular functional state in the body. The majority of previous studies have shown that a high-fat diet (HD) is often associated with a variety of cardiovascular diseases. However, the type of exercise that improves vasoreactivity, as is induced by a HD, remains to be elucidated. In the present study, the effects of aerobic moderate-intensity intermittent exercise through swimming were investigated on thoracic aorta vascular ring contraction and free radical metabolism using Sprague-Dawley rat models of common diet (CD; 23 g protein, 49 g carbohydrate, 4 g fat, 5 g fiber, 7 g bone meal and 6 g vitamins per 100 g), HD (peanuts, milk chocolate and sweet biscuits, in a weight ratio of 3:2:2:1), CD with intermittent exercise (CIE) and HD with intermittent exercise (HIE). The food utilization rate in the swimming group (CIE) decreased in comparison with the CD group. Lee's index in the CIE group decreased in comparison to that of CD after 8 weeks (P<0.05) and also HIE decreased compared to HD (P<0.05) after 8 weeks. Compared with the HD group, contractile response of the thoracic aortic rings to NA decreased in the HIE group, while high-density lipoprotein cholesterol content increased, total cholesterol, triglycerides and low-density lipoprotein cholesterol decreased (P<0.05); the malondialdehyde (MDA) concentration reduced in the myocardium, but the superoxide dismutase (SOD) level improved (P<0.05). In the HIE group, nitric oxide level was similar to the CD group. Compared with CD, contractile response of the thoracic aortic rings to NA increased in the CIE (P<0.05), the MDA concentration reduced in the myocardium, but the SOD level improved (P<0.05). Tunica media smooth muscle of the thoracic aortic rings in the CIE group arranged more regularly in comparison with the CD group (without swimming training). In conclusion, intermittent exercise improves the thoracic aorta vasoreactivity and function by enhanced antioxidant enzyme activity and reduced free radical generating. IntroductionAs living standards improve, high-fat diet-induced obesity has become a common phenomenon (1). Obesity is often associated with a variety of diseases, such as atherosclerosis, hyperlipidemia, hypertension, diabetes and cardiovascular diseases (2-10). Vasoreactivity is the most basic and direct indicator of reflecting artery vascular function state, which has become an important indicator of cardiovascular disease (11). Studies have found that a high-fat diet (HD) and lack of exercise training are the most important factors in the development of obesity. Therefore, exercise training can control obesity and cardiovascular disease, and it has become a research focus. However, the exercise intensity, duration and different diets will produce different effects on metabolic activity (12). Long-term aerobic exercise could markedly improve the abnormal hemorheological property and the oxidative stress in rats with hypercholesterolemia (13). Inadequate nutri...

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Exercise Intensity Modulation of Hepatic Lipid Metabolism

Cited by 38 publications

References 60 publications

Improvement of thoracic aortic vasoreactivity by continuous and intermittent exercise in high-fat diet-induced obese rats

Improvement of thoracic aortic vasoreactivity by continuous and intermittent exercise in high-fat diet-induced obese rats

Linear and undulating periodized strength plus aerobic training promote similar benefits and lead to improvement of insulin resistance on obese adolescents

Intermittent exercise improves the vasoreactivity of the thoracic aorta in rats

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