Exercise may impact on lumbar vertebrae marrow adipose tissue: Randomised controlled trial

Belavý, Daniel L.; Miller, Clint T.; Owen, Patrick J; Rantalainen, Timo; Connell, David; Hahne, Andrew J.; Ford, Jon; Trudel, Guy

doi:10.1016/j.bone.2022.116338

Cited by 8 publications

(6 citation statements)

References 46 publications

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“…A small longitudinal study by Belavy et al is generally consistent with the cross-sectional data [27]. In a pilot RCT of aerobic and resistance exercise in 40 adults, the exercise group experienced a decrease in L2 and L4 BMAT by MRI Dixon at 3 months but not 6 months, although for both time points there were no between group effects.…”

Section: Bone Marrow Adipose Tissue Interventional Studiessupporting

confidence: 61%

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Bone marrow adiposity in diabetes and clinical interventions

Shu

Kim

2022

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of reviewThis study aims to review bone marrow adipose tissue (BMAT) changes in people with diabetes, contributing factors, and interventions. Recent findingsIn type 1 diabetes (T1D), BMAT levels are similar to healthy controls, although few studies have been performed. In type 2 diabetes (T2D), both BMAT content and composition appear altered, and recent bone histomorphometry data suggests increased BMAT is both through adipocyte hyperplasia and hypertrophy. Position emission tomography scanning suggests BMAT is a major source of basal glucose uptake. BMAT is responsive to metabolic interventions. SummaryBMAT is a unique fat depot that is influenced by metabolic factors and proposed to negatively affect the skeleton. BMAT alterations are more consistently seen in T2D compared to T1D. Interventions such as thiazolidinedione treatment may increase BMAT, whereas metformin treatment, weight loss, and exercise may decrease BMAT. Further understanding of the role of BMAT will provide insight into the pathogenesis of diabetic bone disease and could lead to targeted preventive and therapeutic strategies.

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Section: Bone Marrow Adipose Tissue Interventional Studiessupporting

confidence: 61%

“…Cross-sectional studies in T2D have not demonstrated sex differences, but this may reflect small sample sizes. However, interventions may act in a sex-dependent manner as described below [24,26,27]. In obesity, there are mixed data on whether BMAT findings are different in people with T2D.…”

Section: Nondiabetes Related Factorsmentioning

confidence: 99%

Bone marrow adiposity in diabetes and clinical interventions

Shu

Kim

2022

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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“…True-axial Dixon images were used to trace the vertebral bodies and intervertebral discs across the entire lumbar spine (Supplementary Fig. 3 ) 47 . For each anatomical slice, the signal intensity for both water and fat images was recorded.…”

Section: Methodsmentioning

confidence: 99%

Towards data-driven biopsychosocial classification of non-specific chronic low back pain: a pilot study

Tagliaferri,

Owen,

Miller

et al. 2023

Sci Rep

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The classification of non-specific chronic low back pain (CLBP) according to multidimensional data could guide clinical management; yet recent systematic reviews show this has not been attempted. This was a prospective cross-sectional study of participants with CLBP (n = 21) and age-, sex- and height-matched pain-free controls (n = 21). Nervous system, lumbar spinal tissue and psychosocial factors were collected. Dimensionality reduction was followed by fuzzy c-means clustering to determine sub-groups. Machine learning models (Support Vector Machine, k-Nearest Neighbour, Naïve Bayes and Random Forest) were used to determine the accuracy of classification to sub-groups. The primary analysis showed that four factors (cognitive function, depressive symptoms, general self-efficacy and anxiety symptoms) and two clusters (normal versus impaired psychosocial profiles) optimally classified participants. The error rates in classification models ranged from 4.2 to 14.2% when only CLBP patients were considered and increased to 24.2 to 37.5% when pain-free controls were added. This data-driven pilot study classified participants with CLBP into sub-groups, primarily based on psychosocial factors. This contributes to the literature as it was the first study to evaluate data-driven machine learning CLBP classification based on nervous system, lumbar spinal tissue and psychosocial factors. Future studies with larger sample sizes should validate these findings.

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“…1,25 dihydroxy vitamin D is the active form of vitamin D, and its main function in bone is to modulate osteoblast proliferation, differentiation, and providing suitable microenvironment for bone mineralization. Presence of calcitriol in aging osteoblast cultures revealed enhanced osteoblastic function ( 164 ). Different mechanisms of action have been proposed for the effect of vitamin D on osteoblast differentiation and bone formation ( 165 , 166 ).…”

Section: Interventions To Reduce Bma Enhance Bone Mass and Reduce Bon...mentioning

confidence: 99%

The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity

Ali

Tencerová²,

Figeac³

et al. 2022

Front. Endocrinol.

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Osteoporosis is defined as a systemic skeletal disease characterized by decreased bone mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis incidence increases with age in both post-menopausal women and aging men. Among other important contributing factors to bone fragility observed in osteoporosis, that also affect the elderly population, are metabolic disturbances observed in obesity and Type 2 Diabetes (T2D). These metabolic complications are associated with impaired bone homeostasis and a higher fracture risk. Expansion of the Bone Marrow Adipose Tissue (BMAT), at the expense of decreased bone formation, is thought to be one of the key pathogenic mechanisms underlying osteoporosis and bone fragility in obesity and T2D. Our review provides a summary of mechanisms behind increased Bone Marrow Adiposity (BMA) during aging and highlights the pre-clinical and clinical studies connecting obesity and T2D, to BMA and bone fragility in aging osteoporotic women and men.

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Exercise may impact on lumbar vertebrae marrow adipose tissue: Randomised controlled trial

Cited by 8 publications

References 46 publications

Bone marrow adiposity in diabetes and clinical interventions

Bone marrow adiposity in diabetes and clinical interventions

Towards data-driven biopsychosocial classification of non-specific chronic low back pain: a pilot study

The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity

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