Exercise, Obesity, and Cutaneous Wound Healing: Evidence from Rodent and Human Studies

Pence, Brandt D.; Woods, Jeffrey A.

doi:10.1089/wound.2012.0377

Cited by 84 publications

(80 citation statements)

References 44 publications

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“…EGF has previously been described as promoting cell growth [21], enhancing keratinocyte migration [23], inhibiting apoptosis under hypoxic conditions [24], and supporting reepithelization and skin healing [25,26]. Additionally, EGF supports the healing process of chronic wounds [27], nonhealing chronic wounds and ulcers, which are, for example, observed in diabetic patients known to lack the necessary growth factors to maintain the healing process [28,29]. Thus, such patient groups may benefit from the application of PRF matrices as an autologous drug delivery system.…”

Section: Discussionmentioning

confidence: 99%

Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept)

Bagdadi

Kubesch

et al. 2017

Eur J Trauma Emerg Surg

148

135

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Moreover, platelets were located homogenously throughout the matrix in the A-PRF and A-PRF+ groups, whereas platelets in PRF were primarily observed within the lower portion. Discussion the present results show an increase growthfactor release by decreased RCF. However, further studies must be conducted to examine the extent to which enhancing the amount and the rate of released growth factors influence wound healing and biomaterial-based tissue regeneration. Conclusion These outcomes accentuate the fact that with a reduction of RCF according to the previously LSCC (described low speed centrifugation concept), growth factor release can be increased in leukocytes and platelets within the solid PRF matrices.

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Section: Discussionmentioning

confidence: 99%

Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept)

Bagdadi

Kubesch

et al. 2017

Eur J Trauma Emerg Surg

148

135

View full text Add to dashboard Cite

show abstract

“…The systemic changes characteristic of diabetes progression, including hyperglycemia (6,7), insulin resistance (8), obesity (9,10), and subsequent microvascular (11)(12)(13)(14) or macrovascular complications (15), as well as localized factors, have been associated with an increased risk of diabetic foot ulcers. Multiple treatment modalities using cytokine replacement (16) and transplantation of keratinocytes or fibroblasts are effective in nondiabetic populations (17)(18)(19), but their efficacy in patients with diabetes is diminished as a result of undetermined mechanisms (17).…”

Section: Introductionmentioning

confidence: 99%

PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts

Khamaisi¹,

Katagiri²,

Keenan³

et al. 2016

Journal of Clinical Investigation

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“…These clinical and biochemical results suggest that preoperative exercise can lead to improved flap survival or, at the very least, that sedentary behavior is conducive for necrosis and ultimately partial flap failure. Although our data may attempt to explain the mechanism of previous reports [1][2][3][4] of the benefits of exercise in wound healing, we have only begun to scratch the surface. Our results suggest that preoperative cardiovascular exercise may improve flap outcomes in patients undergoing reconstructive surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies [2][3][4] have found that cardiovascular exercise hastens wound healing in not only the rodent population but also humans. Indeed, the effect on humans varies from biochemical and immunologic measures to emotional and cognitive effects.…”

mentioning

confidence: 99%

Biochemical Effects of Exercise on a Fasciocutaneous Flap in a Rat Model

Aksamitiene

Baker

Roy

et al. 2017

JAMA Facial Plast Surg

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IMPORTANCE An overwhelming amount of data suggest that cardiovascular exercise has a positive effect on the mind and body, although the precise mechanism is not always clear.OBJECTIVE To assess the clinical and biochemical effects of voluntary cardiovascular exercise on pedicled flaps in a rodent model. DESIGN, SETTING, AND PARTICIPANTSEighteen adult Sprague-Dawley male rats were randomized into a resting animal group (RAG) (n=9) and an exercise animal group (EAG) (n=9) for 14 days (July 23, 2013, through July 30, 2013. A pedicled transposition flap was performed on the ventral surface of the rat, and biopsy specimens were taken from the proximal, middle, and distal portions on postoperative days 0, 2, 5, and 9. Flap survival was analyzed planimetrically, and biopsy specimens were analyzed by hematoxylin-eosin-stained microscopy and immunoblotting. The housing, exercise, surgery, and analysis of the rats were conducted at a single basic science research laboratory at the tertiary care center campus of

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Exercise, Obesity, and Cutaneous Wound Healing: Evidence from Rodent and Human Studies

Cited by 84 publications

References 44 publications

Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept)

Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept)

PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts

Biochemical Effects of Exercise on a Fasciocutaneous Flap in a Rat Model

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