Exercise, oxidative stress and hormesis

Radák, Zsolt

doi:10.1016/j.toxlet.2014.06.090

Cited by 71 publications

(101 citation statements)

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“…High intensity or prolonged duration may produce an open window indicating higher risk for infections 13 . However, carbohydrate sup- plementation may improve the immune function in response to exercise since it preserves glutamine and maintains the glucose availability to the leukocytes 14 .…”

Section: Discussionmentioning

confidence: 99%

Efeitos da suplementação carboidratada e de diferentes tipos de treinamento físico sobre as concentrações de células sanguíneas

Rombaldi¹,

Leite²,

Hartleben³

et al. 2013

Rev Bras Med Esporte

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Introduction: The participation of athletes in sessions of intense and prolonged exercise can lower the number and functional capacity of circulating leukocytes. On the other hand, the intake of a carbohydrate solution can attenuate the immunosuppressive effects of exercise. Objective: To evaluate the effects of aerobic and anaerobic exercises, and carbohydrate supplementation on blood concentrations of total and differential counts of leukocytes, hemoglobin and serum glucose in Wistar rats. Methods: 69 Male Wistar rats (60 days) were divided into six groups: sedentary non--supplemented (n = 12) and supplemented (n = 12); trained in Maximum Lactate Steady State (MLSS) not supplemented (n = 11) and supplemented (n = 11); trained at high intensity non-supplemented (n = 12) and supplemented (n = 11). The training protocol consisted of eight weeks of continuous swimming pattern MLSS (60min.day

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Section: Discussionmentioning

confidence: 99%

Efeitos da suplementação carboidratada e de diferentes tipos de treinamento físico sobre as concentrações de células sanguíneas

Rombaldi¹,

Leite²,

Hartleben³

et al. 2013

Rev Bras Med Esporte

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“…It is possible that life-long high volume, high intensity aerobic exercise training may not be optimal for protecting brain perfusion from the age-related decline. 24,25 In this regard, our recent study demonstrated that 3 months of moderate aerobic exercise training increased global CBF in the elderly women over 60 years. 26 Thus, further longitudinal studies are needed to determine if indeed there is a 'dose-response' relationship between exercise training and brain perfusion.…”

Section: Effects Of Age and Exercise On Basal Cerebral Blood Flowmentioning

confidence: 92%

Cerebral Vasomotor Reactivity during Hypo- and Hypercapnia in Sedentary Elderly and Masters Athletes

Zhu

Tarumi

Tseng

et al. 2013

J Cereb Blood Flow Metab

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Physical activity may influence cerebrovascular function. The objective of this study was to determine the impact of life-long aerobic exercise training on cerebral vasomotor reactivity (CVMR) to changes in end-tidal CO2 (EtCO2) in older adults. Eleven sedentary young (SY, 27 ± 5 years), 10 sedentary elderly (SE, 72 ± 4 years), and 11 Masters athletes (MA, 72 ± 6 years) underwent the measurements of cerebral blood flow velocity (CBFV), arterial blood pressure, and EtCO2 during hypocapnic hyperventilation and hypercapnic rebreathing. Baseline CBFV was lower in SE and MA than in SY while no difference was observed between SE and MA. During hypocapnia, CVMR was lower in SE and MA compared with SY (1.87 ± 0.42 and 1.47 ± 0.21 vs. 2.18 ± 0.28 CBFV%/mm Hg, Po0.05) while being lowest in MA among all groups (Po0.05). In response to hypercapnia, SE and MA exhibited greater CVMR than SY (6.00 ± 0.94 and 6.67 ± 1.09 vs. 3.70 ± 1.08 CBFV1%/mm Hg, Po0.05) while no difference was observed between SE and MA. A negative linear correlation between hypo-and hypercapnic CVMR (R 2 ¼ 0.37, Po0.001) was observed across all groups. Advanced age was associated with lower resting CBFV and lower hypocapnic but greater hypercapnic CVMR. However, life-long aerobic exercise training appears to have minimal effects on these age-related differences in cerebral hemodynamics.

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“…These data suggest that exerciseassociated PPARγ signalling effects appear, at least in monocytes, to be mediated by Exercise is well recognised as a systemic oxidative stressor [1][2][3][4][5]. This has been attributed to reactive oxygen species (ROS) being released from contracting skeletal myocytes; for example, H 2 O 2 's long half-life is known to permit its diffusion across the myocyte membrane and thence its transport to other regions of the body [1,2].…”

mentioning

confidence: 99%

“…Hence, whereas prolonged exposure to high levels of ROS brings about cell damage, repeated exerciseassociated transient increases in ROS may -via triggering of PPARγ/PGC-1α signalling -underpin adaptive signalling processes which ultimately prove to be beneficial to health [4,21].…”

mentioning

confidence: 99%

The contributions of oxidative stress, oxidised lipoproteins and AMPK towards exercise-associated PPARγ signalling within human monocytic cells

Davies

Watkeys

Butcher

et al. 2014

Free Radical Research

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Exercise, oxidative stress and hormesis

Cited by 71 publications

References 0 publications

Efeitos da suplementação carboidratada e de diferentes tipos de treinamento físico sobre as concentrações de células sanguíneas

Efeitos da suplementação carboidratada e de diferentes tipos de treinamento físico sobre as concentrações de células sanguíneas

Cerebral Vasomotor Reactivity during Hypo- and Hypercapnia in Sedentary Elderly and Masters Athletes

The contributions of oxidative stress, oxidised lipoproteins and AMPK towards exercise-associated PPARγ signalling within human monocytic cells

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