Exercise prevents sleep deprivation-associated anxiety-like behavior in rats: Potential role of oxidative stress mechanisms

Vollert, Craig; Zagaar, Munder; Hovatta, Iiris; Taneja, Manish; Vu, Anthony; Dao, An T.; Levine, Amber T.; Alkadhi, Karim A.; Salim, Samina

doi:10.1016/j.bbr.2011.05.010

Cited by 180 publications

(203 citation statements)

References 54 publications

Supporting

Mentioning

193

Contrasting

Order By: Relevance

“…Our data indicated that TSD and to a greater extent CPSR, induced anxiolytic-like effect. This is in contrary to some reports showing that multiple platform method-induced SD was anxiogenic that might be due to the induced-oxidative damage in the brain (40,41); however, our results replicated and extended findings of Tartar et al indicating that 24 hours of treadmill-induced TSD increases exploratory behavior in an open-field test of anxiety (OAT%) in comparison to cage or exercise controls (42). Therefore, it is plausible that the anxiolytic-like effect of SD, which might be due to the method we used for SD induction, made the animals exercise while being sleep deprived.…”

Section: Discussioncontrasting

confidence: 99%

Aversive Memory, Anxiety-Related Behaviors, and Serum Neurochemical Levels in a Rat Model of Labored Sleep Loss

et al. 2014

View full text Add to dashboard Cite

Background: Sleep deprivation (SD) is emerging as a hot topic due to its health concerns. There are compelling reasons for a tremendous interest in neuroscience of sleep in recent years. Objectives: We aimed to evaluate how total sleep deprivation (TSD) and chronic partial sleep restriction (CPSR) might affect memory, anxiety-related behaviors, and the serum level of neurochemical markers such as brain-derived neurotrophic factor (BDNF) and corticosterone in a rat model. Materials and Methods:The disk-over-water (DOW) apparatus was employed to induce TSD and CPSR in male Wistar rats. The six study arms were as follows: cage control, 48 hours; cage control, seven days; DOW control, 48 hours; DOW control, seven days, TSD, and CPSR. Elevated plus-maze (EPM) was used to measure parameters (percentage of OAT, percentage of OAE, and locomotor activity) corresponding to anxiety and aversive memory. To measure serum BDNF and corticosterone levels using the ELISA method, blood samples were drawn from all rats on the fourth day at 5 P.M. Results: Our results demonstrated that TSD (P < 0.001) and CPSR (P < 0.001) induce memory impairment while exert anxiolytic-like effects in comparison with controls. Data showed that CPSR causes more memory impairment and anxiolytic-like effect in comparison to TSD (P < 0.001).These interventions however, did not alter the locomotor activity. Serum corticosterone level raised dramatically in CPSR rats in comparison to TSD and controls. Although the difference in serum BDNF level between TSD and CPSR arms was insignificant, it was markedly decreased in comparison to corresponding controls (P < 0.001). Conclusions: Our findings suggest the more pronounced effect of CPSR rather than TSD in impairing aversive memory and reducing anxiety. Decreased BDNF and peaked corticosterone level in TSD and CPSR suggest the probable inflammatory processes involved in possible insults to the brain caused by SD.

show abstract

Section: Discussioncontrasting

confidence: 99%

Aversive Memory, Anxiety-Related Behaviors, and Serum Neurochemical Levels in a Rat Model of Labored Sleep Loss

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Extensive research has been conducted to reveal multiple neural substrates and mechanisms that contribute to the etiology of depression and anxiety, among which the imbalance between oxidation and antioxidant defense system has gained attention (30). Some studies demonstrated the role of oxidative stress in anxiety of rodents (47,48). According to this, it has been shown that induction of oxidative stress in mice occurs in same time with anxiety (49).…”

Section: Discussionmentioning

confidence: 99%

Anxiolytic Effect of Borago officinalis (Boraginaceae) Extract in Male Rats

Komaki‬¹,

Rasouli²,

Shahidi³

2015

Avicenna J Neuro Psych Physio

View full text Add to dashboard Cite

Background: Medicinal plants with natural antioxidants have been shown to be beneficial in a variety of complications such as anxiety. The elevated plus-maze (EPM) is one of the most widely used models to assess anxiety in small rodents. Objectives: This study was designed to characterize the anxiolytic-like activity of Borago officinalis (Linnaeus, family Boraginaceae) or Borage flowers extract, using an EPM test. Materials and Methods: Male Wistar rats weighing 220-250 grams were used in the present study. Thirty minutes after an intraperitoneal (IP) injection of the Borage extract (50, 100, 200 mg/kg) or saline, each animal was placed in the EPM. Animal behaviors in the experimental sessions were recorded by a video camera located above the maze, interfaced with a monitor and a computer in an adjacent room. The time spent in the open arms, the percentage of entries into the open arms of the EPM and the numbers of entries into the closed arms were recorded for five minutes. Results: Statistical analysis indicated that acute IP injection of Borage extract before an EPM trial significantly increased the time spent in open arms and percentage of open arms entries. Whereas, the extract had no effect on the number of closed arm entries. Conclusions: Our results demonstrated that injection of Borage extract might have an anxiolytic profile in rats. However, the exact mechanism (s) related to the active compound (s) in Borage extract should be elucidated in future studies.

show abstract

“…It seems that sleep is the main factor in the acquisition and consolidation of memory (4,5). Therefore, sleep deprivation (SD) impairs spatial (6,7), emotional (8), and working memories (9), and augments anxiety like behaviors (10). As a result, hippocampus is very sensitive to sleep loss (11,12).…”

Section: Introduction and Statement Of The Problemmentioning

confidence: 99%

A Review of Protective Effects of Exercise on Cognitive Impairments Induced by Sleep Deprivation in Female Rats

Saadati

2017

Arch Neurosci

View full text Add to dashboard Cite

Sleep is an important factor in memory consolidation and brain health. In addition, sleep disorder is a common complaint among females in comparison with males. In menopausal females, to relieve sleep disturbances and other menopausal symptoms, hormone therapy may be used. Furthermore, although estrogen had helpful effects on the brain performance, hormone replacement therapy augmented unfavorable cardiovascular and oncological side effects. It is implied that exercise is a powerful nonpharmacological intervention that can develop the cognitive performances. The current study used the behavioral, physiological, and molecular evidence supporting these views.

show abstract

Exercise prevents sleep deprivation-associated anxiety-like behavior in rats: Potential role of oxidative stress mechanisms

Cited by 180 publications

References 54 publications

Aversive Memory, Anxiety-Related Behaviors, and Serum Neurochemical Levels in a Rat Model of Labored Sleep Loss

Aversive Memory, Anxiety-Related Behaviors, and Serum Neurochemical Levels in a Rat Model of Labored Sleep Loss

Anxiolytic Effect of Borago officinalis (Boraginaceae) Extract in Male Rats

A Review of Protective Effects of Exercise on Cognitive Impairments Induced by Sleep Deprivation in Female Rats

Contact Info

Product

Resources

About