Exercise reduces hyperlipidemia‑induced kidney damage in apolipoprotein E‑deficient mice

Qian, Chengsi; Yang, Qin; Guo, Lipeng; Zhu, Hupei; You, Xi; Li, Hongyang; Sun, Yan

doi:10.3892/etm.2020.9585

Cited by 6 publications

(6 citation statements)

References 41 publications

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“…In addition, the increase of oxidative stress is also reflected in the upregulation of key regulatory factors of the oxidative stress response ( Loboda et al, 2016 ). Qian et al. (2021) used ApoE-/- mice to study the effect of 12 weeks of swimming exercise on high-fat induced renal injury.…”

Section: Survey Methodologymentioning

confidence: 99%

“…Exercise may regulate blood lipid metabolism and significantly decrease TG, TC, and LDL-C values ( Banz et al, 2003 ; Hui et al, 2015 ). Recently, Qian et al (2021) found that exercise also protects against renal damage caused by hyperlipidemia. The effects of exercise on hyperlipidemia-renal injury have gradually emerged, but the specific mechanism remains to be explored ( Qian et al, 2021 ; Wang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, Qian et al (2021) found that exercise also protects against renal damage caused by hyperlipidemia. The effects of exercise on hyperlipidemia-renal injury have gradually emerged, but the specific mechanism remains to be explored ( Qian et al, 2021 ; Wang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Few studies have examined the mechanisms of hyperlipidemia-renal injury in terms of different kidney cells, which have different functions, and the injury mechanism in the disease ( Kang & Zhang, 2022 ; Ruan, 2018 ). Additionally, the role of exercise is not clear and the regulatory mechanism has only been partially studied ( Qian et al, 2021 ; Wang et al, 2021 ). As more patients are afflicted by this disease, it is important to understand the pathogenesis and pathomechanism of hyperlipidemia-renal injury from the perspective of different cells in order to find appropriate therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

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The role of exercise in improving hyperlipidemia-renal injuries induced by a high-fat diet: a literature review

Chen

Xie

Hong

2023

PeerJ

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A diet that is high in sugar and fat is a precursor to various chronic diseases, especially hyperlipidemia. Patients with hyperlipidemia have increased levels of plasma free fatty acids and an ectopic accumulation of lipids. The kidney is one of the main organs affected by this disease and, recently, there have been more studies conducted on renal injury caused by hyperlipidemia. The main pathological mechanism is closely related to renal lipotoxicity. However, in different kidney cells, the reaction mechanism varies due to the different affinities of the lipid receptors. At present, it is believed that in addition to lipotoxicity, hyperlipidemia induced-renal injury is also closely related to oxidative stress, endoplasmic reticulum stress, and inflammatory reactions, which are the result of multiple factors. Exercise plays an important role in the prevention of various chronic diseases and recently emerging researches indicated its positive effects to renal injury caused by hyperlipidemia. However, there are few studies summarizing the effects of exercise on this disease and the specific mechanisms need to be further explored. This article summarizes the mechanisms of hyperlipidemia induced-renal injury at the cellular level and discusses the ways in which exercise may regulate it. The results provide theoretical support and novel approaches for identifying the intervention target to treat hyperlipidemia induced-renal injury.

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Section: Survey Methodologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The role of exercise in improving hyperlipidemia-renal injuries induced by a high-fat diet: a literature review

Chen

Xie

Hong

2023

PeerJ

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“…MetS is approximately three times more common than diabetes, and the estimated global prevalence is approximately one-quarter of the world population ( Saklayen, 2018 ). Currently, a growing number of studies have reported that obesity ( Xu et al, 2021 ), hypertension ( Sun et al, 2020 ), diabetes, and hyperlipidemia ( Qian et al, 2021 ) can induce a wide range of kidney diseases. Therefore, MetS is prone to cause kidney injury.…”

Section: Introductionmentioning

confidence: 99%

Advances of berberine against metabolic syndrome-associated kidney disease: Regarding effect and mechanism

et al. 2023

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The prevalence of metabolic syndrome (MetS) is drastically growing worldwide, resulting in MetS-associated kidney disease. According to traditional theories, preventing blood pressure, lipid, glycose, and obesity and improving insulin resistance (IR), a couple of medications are required for MetS. It not only lowers patients’ compliance but also elevates adverse reactions. Accordingly, we attempted to seek answers from complementary and alternative medicine. Ultimately, berberine (BBR) was chosen due to its efficacy and safety on MetS through multi-pathways and multi-targets. The effects and mechanisms of BBR on obesity, IR, diabetic nephropathy, hypertension, hyperlipidemia, and hyperuricemia were elaborated. In addition, the overall properties of BBR and interventions for various kidney diseases were also collected. However, more clinical trials are expected to further identify the beneficial effects of BBR.

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Cholesterol Metabolism in Chronic Kidney Disease: Physiology, Pathologic Mechanisms, and Treatment

Pan

2022

Advances in Experimental Medicine and Biology

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Exercise reduces hyperlipidemia‑induced kidney damage in apolipoprotein E‑deficient mice

Cited by 6 publications

References 41 publications

The role of exercise in improving hyperlipidemia-renal injuries induced by a high-fat diet: a literature review

The role of exercise in improving hyperlipidemia-renal injuries induced by a high-fat diet: a literature review

Advances of berberine against metabolic syndrome-associated kidney disease: Regarding effect and mechanism

Cholesterol Metabolism in Chronic Kidney Disease: Physiology, Pathologic Mechanisms, and Treatment

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