Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells

Frodermann, Vanessa; Rohde, David; Courties, Gabriel; Sévère, Nicolas; Schloss, Maximilian J.; Amatullah, Hajera; McAlpine, Cameron S.; Cremer, Sebastian; Hoyer, Friedrich Felix; Ji, Fei; Koeverden, Ian D. van; Herisson, Fanny; Honold, Lisa; Masson, Gustavo Santos; Zhang, Shuang; Grune, Jana; Iwamoto, Yoshiko; Schmidt, Stephen; Wojtkiewicz, Gregory R.; Lee, I-Hsiu; Gustafsson, Karin; Pasterkamp, Gérard; Jager, Saskia C.A. de; Sadreyev, Ruslan I.; MacFadyen, Jean; Libby, Peter; Ridker, Paul M.; Scadden, David T.; Naxerova, Kamila; Jeffrey, Kate L.; Świrski, Filip K.; Nahrendorf, Matthias

doi:10.1038/s41591-019-0633-x

Cited by 192 publications

(191 citation statements)

References 78 publications

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“…Increased marrow adipocytes, in turn, reduce the number of HSCs [70−72]. In contrast, a recent study suggests that exercise reduces leptin, a hormone that governs energy expenditure, and reduction of leptin instructs BMSCs to express HSC niche factors to promote HSC quiescence [73]. These studies illuminate the links between metabolic and physical conditions to the bone marrow microenvironment to support HSCs, with obesity and exercise negatively and positively affecting HSCs, respectively.…”

Section: Diet Metabolism and Clonal Hematopoiesismentioning

confidence: 99%

Environmental influences on clonal hematopoiesis

King

Huang

Nakada

et al. 2020

Experimental Hematology

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Section: Diet Metabolism and Clonal Hematopoiesismentioning

confidence: 99%

Environmental influences on clonal hematopoiesis

King

Huang

Nakada

et al. 2020

Experimental Hematology

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“…At high concentrations, leptin stimulates oxidative stress, inflammation, thrombosis, angiogenesis, and atherogenesis, which predispose CVD [109]. In contrast, voluntary physical activity reduces leptin signaling to the stromal hematopoietic bone marrow niche, consequently decreasing chronic hematopoietic output of inflammatory leukocytes and protecting from CVD [110].…”

Section: Leptinmentioning

confidence: 99%

Adipokines and Adipose Tissue-Related Metabolites, Nuts and Cardiovascular Disease

Weschenfelder¹,

Quadros²,

Santos³

et al. 2020

Metabolites

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Adipose tissue is a complex structure responsible for fat storage and releasing polypeptides (adipokines) and metabolites, with systemic actions including body weight balance, appetite regulation, glucose homeostasis, and blood pressure control. Signals sent from different tissues are generated and integrated in adipose tissue; thus, there is a close connection between this endocrine organ and different organs and systems such as the gut and the cardiovascular system. It is known that functional foods, especially different nuts, may be related to a net of molecular mechanisms contributing to cardiometabolic health. Despite being energy-dense foods, nut consumption has been associated with no weight gain, weight loss, and lower risk of becoming overweight or obese. Several studies have reported beneficial effects after nut consumption on glucose control, appetite suppression, metabolites related to adipose tissue and gut microbiota, and on adipokines due to their fatty acid profile, vegetable proteins, l-arginine, dietary fibers, vitamins, minerals, and phytosterols. The aim of this review is to briefly describe possible mechanisms implicated in weight homeostasis related to different nuts, as well as studies that have evaluated the effects of nut consumption on adipokines and metabolites related to adipose tissue and gut microbiota in animal models, healthy individuals, and primary and secondary cardiovascular prevention.

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“…Recently, Frodermann et al provided evidence that the exercise decreased the release of hematopoietic progenitor cells from the bone marrow by modulating the leptin release from the adipocyte. In this manner, the cardiovascular damage was relieved by lessening the inflammatory process [87]. This evidence gave us clues that the pathologic status induced the inflammatory differentiation of hematopoietic progenitor cells, and that such inflammation worsened the endothelial injury.…”

Section: Hematopoietic Progenitor Cells and Arterial Calcificationmentioning

confidence: 88%

The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification

Hou

Zheng

et al. 2020

IJMS

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Vascular calcification, which involves the deposition of calcifying particles within the arterial wall, is mediated by atherosclerosis, vascular smooth muscle cell osteoblastic changes, adventitial mesenchymal stem cell osteoblastic differentiation, and insufficiency of the calcification inhibitors. Recent observations implied a role for mesenchymal stem cells and endothelial progenitor cells in vascular calcification. Mesenchymal stem cells reside in the bone marrow and the adventitial layer of arteries. Endothelial progenitor cells that originate from the bone marrow are an important mechanism for repairing injured endothelial cells. Mesenchymal stem cells may differentiate osteogenically by inflammation or by specific stimuli, which can activate calcification. However, the bioactive substances secreted from mesenchymal stem cells have been shown to mitigate vascular calcification by suppressing inflammation, bone morphogenetic protein 2, and the Wingless-INT signal. Vitamin D deficiency may contribute to vascular calcification. Vitamin D supplement has been used to modulate the osteoblastic differentiation of mesenchymal stem cells and to lessen vascular injury by stimulating adhesion and migration of endothelial progenitor cells. This narrative review clarifies the role of mesenchymal stem cells and the possible role of vitamin D in the mechanisms of vascular calcification.

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Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells

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Cited by 192 publications

References 78 publications

Environmental influences on clonal hematopoiesis

Environmental influences on clonal hematopoiesis

Adipokines and Adipose Tissue-Related Metabolites, Nuts and Cardiovascular Disease

The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification

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