Exercise suppresses NLRP3 inflammasome activation in mice with diet-induced NASH: a plausible role of adropin

Yang, Wenqi; Liu, Ling; Yuan, Wei; Fang, Chunlu; Liu, Shujing; Zhou, Fu; Li, Yaping; Zhao, Guisen; Guo, Ziyi; Luo, Yuan; Li, Liangming

doi:10.1038/s41374-020-00508-y

Cited by 38 publications

(26 citation statements)

References 46 publications

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“…NO can also reduce skin vascular resistance, thereby reducing hypertension. Third, NLRP3 inflammasome damages endothelial cells, and exercise reduces the expression of NLRP3 inflammasome components, thereby lowering blood pressure [ 39 , 40 ]. Fourth, performing Tai Chi can cultivate the mind, edify sentiments, make people broad-minded, open-minded, and optimistic, and eliminate the effects of bad mood on the nervous system caused by changes in blood pressure [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Tai Chi as a Therapy of Traditional Chinese Medicine on Reducing Blood Pressure: A Systematic Review of Randomized Controlled Trials

Pan

Tian

Yang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. This study systematically evaluated the effects of Tai Chi exercise on blood pressure, body mass index (BMI), and quality of life (QOL) in patients with hypertension. A meta-analysis was performed to provide a reliable reference for clinical practice. Methods. We searched for randomized controlled trials (RCTs) in five English databases and two Chinese databases, with the earliest data dated December 5, 2020. A quality assessment of the methods and a meta-analysis were also conducted. Results. The meta-analysis of 24 studies showed that the intervention group showed better outcomes in terms of systolic blood pressure (SBP) (SMD −1.05, 95% CI −1.44 to −0.67, P ≤ 0.001 ; I2 = 93.7%), diastolic blood pressure (DBP) (SMD −0.91, 95% CI −1.24 to −0.58, P ≤ 0.001 ; I2 = 91.9%), and QOL (physical functioning (SMD 0.86, 95% CI 0.36 to 1.37, P = 0.001 ; I2 = 91.3%), role-physical (SMD 0.86, 95% CI 0.61 to 1.11, P ≤ 0.001 ; I2 = 65%), general health (SMD 0.75, 95% CI 0.32 to 1.17, P = 0.001 ; I2 = 88.1%), bodily pain (SMD 0.65, 95% CI 0.29 to 1.00, P ≤ 0.001 ; I2 = 83.1%), vitality (SMD 0.71, 95% CI 0.34 to 1.07, P ≤ 0.001 ; I2 = 84.3%), social functioning (SMD 0.63, 95% CI 0.07 to 1.19, P = 0.027 ; I2 = 93.1%), role-emotional (SMD 0.64, 95% CI 0.22 to 1.06, P = 0.003 ; I2 = 88.1%), and mental health (SMD 0.73, 95% CI 0.31 to 1.16, P = 0.001 ; I2 = 88.2%)) compared to those of the control group. However, no significant improvements were seen in BMI of the intervention group (SMD −0.08, 95% CI −0.35 to −0.19, P = 0.554 ; I2 = 69.4%) compared to that of the control group. Conclusion. Tai Chi is an effective intervention to improve SBP and DBP in patients with essential hypertension.

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Section: Discussionmentioning

confidence: 99%

Tai Chi as a Therapy of Traditional Chinese Medicine on Reducing Blood Pressure: A Systematic Review of Randomized Controlled Trials

Pan

Tian

Yang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

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“…Inhibition of NLRP3 activation could effectively dull hepatocyte lipid accumulation and inflammation [32,33]. And exercise is shown to inhibit the activation of hepatic NLRP3 inflammasome in HFD-fed mice [34]. As shown in Fig.…”

Section: (Caption On Next Page)mentioning

confidence: 96%

“…NLRP3 inflammasome has been previously proved to aggravate lipid deposition in liver, and exercise can effectively inhibit the activity of NLRP3 inflammasome [32][33][34]. The activation NLRP3 inflammasome could be triggered by the oxidized-mitochondrial DNA (ox-mtDNA) released into cytosol [39].…”

Section: Disscusionmentioning

confidence: 99%

Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice

Zhu

Chen

et al. 2022

Metabolism

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“…As shown in Table 1 , endurance training was most widely used and treadmill running was the main exercise mode, followed by swimming and voluntary wheel running. It is worth mentioning that moderate-intensity treadmill exercise over 4 weeks was generally demonstrated to significantly inhibit the overactivation of the NLRP3 inflammasome of mice and rats in adipose tissue [ 49 , 50 ], liver [ 51 , 52 ], myocardium [ 53 , 54 , 55 ] hippocampus [ 56 , 57 , 58 , 59 , 60 , 61 ], prefrontal cortex [ 63 ] and substantia nigra [ 62 ] which were caused by metabolic disorder, DEN (diethylnitrosamine) damage, hypoxia, myocardial hypertrophy, aging, myocardial infarction, ovariectomy, Alzheimer’s’ disease, depression, cerebral ischemia and ischemia reperfusion. Similarly, human studies also showed that chronic moderate-intensity running significantly reduced the NLRP3 inflammasome activation in peripheral blood mononuclear cells (PBMCs) of healthy young men, while chronic high-intensity running activated the NLRP3 inflammasome [ 64 ].…”

Section: Effect Of Exercise On Nlrp3 Inflammasome Activationmentioning

confidence: 99%

Research Progress of Mitochondrial Mechanism in NLRP3 Inflammasome Activation and Exercise Regulation of NLRP3 Inflammasome

Zhang

Ding

Wang

2021

IJMS

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NLRP3 is an important pattern recognition receptor in the innate immune system, and its activation induces a large number of pro-inflammatory cytokines, IL-1β and IL-18 which are involved in the development of various diseases. In recent years, it has been suggested that mitochondria are the platform for NLRP3 inflammasome activation. Additionally, exercise is considered as an important intervention strategy to mediate the innate immune responses. Generally, chronic moderate-intensity endurance training, resistance training and high-intensity interval training inhibit NLRP3 inflammasome activation in response to various pathological factors. In contrast, acute exercise activates NLRP3 inflammasome. However, the mechanisms by which exercise regulates NLRP3 inflammasome activation are largely unclear. Therefore, the mechanism of NLRP3 inflammasome activation is discussed mainly from the perspective of mitochondria in this review. Moreover, the effect and potential mechanism of exercise on NLRP3 inflammasome are explored, hoping to provide new target for relevant research.

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Exercise suppresses NLRP3 inflammasome activation in mice with diet-induced NASH: a plausible role of adropin

Cited by 38 publications

References 46 publications

Tai Chi as a Therapy of Traditional Chinese Medicine on Reducing Blood Pressure: A Systematic Review of Randomized Controlled Trials

Tai Chi as a Therapy of Traditional Chinese Medicine on Reducing Blood Pressure: A Systematic Review of Randomized Controlled Trials

Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice

Research Progress of Mitochondrial Mechanism in NLRP3 Inflammasome Activation and Exercise Regulation of NLRP3 Inflammasome

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