2018
DOI: 10.1016/j.exger.2018.04.003
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Exercise training causes a partial improvement through increasing testosterone and eNOS for erectile function in middle-aged rats

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Cited by 17 publications
(9 citation statements)
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“…No significant difference in CRBN among the three groups was observed (Figure 2D). The level of AMPK, which was blocked by PKA [18] and directly affected by CRBN [13], in the STZ group was significantly lower than in the CON group ( p < 0.05), while the level of AMPK in the STZ + EXE group was significantly higher than in the STZ group ( p < 0.005, Figure 2E). The level of Akt, which interacts with AMPK [19], significantly increased in the STZ + EXE groups as compared to the STZ group ( p < 0.05, Figure 2F).…”
Section: Resultsmentioning
confidence: 99%
“…No significant difference in CRBN among the three groups was observed (Figure 2D). The level of AMPK, which was blocked by PKA [18] and directly affected by CRBN [13], in the STZ group was significantly lower than in the CON group ( p < 0.05), while the level of AMPK in the STZ + EXE group was significantly higher than in the STZ group ( p < 0.005, Figure 2E). The level of Akt, which interacts with AMPK [19], significantly increased in the STZ + EXE groups as compared to the STZ group ( p < 0.05, Figure 2F).…”
Section: Resultsmentioning
confidence: 99%
“…A recent study by Seo et al showed that exercise training has beneficial effects on erectile function in aged rats by increased T production from the testis and strengthening of the cavernous endothelium with the activation of eNOS. 24 In a previous study, T was shown to induce NO production in human amniotic epithelial cells via androgen receptor-dependent activation of eNOS. 25 Another study showed that in human umbilical vein endothelial cells, both T and DHT induced NO synthesis via eNOS activation, along with increased levels of eNOS.…”
Section: Discussionmentioning
confidence: 96%
“…However, the exact molecular basis underlying the regulation of NOS by T still remains to be fully elucidated. A recent study by Seo et al showed that exercise training has beneficial effects on erectile function in aged rats by increased T production from the testis and strengthening of the cavernous endothelium with the activation of eNOS 24 . In a previous study, T was shown to induce NO production in human amniotic epithelial cells via androgen receptor‐dependent activation of eNOS 25 .…”
Section: Discussionmentioning
confidence: 98%
“…Since the current study used RS female and age matched male rats, the effects of estrogen on cognition might be weaned off while those of testosterone (Bimonte-Nelson et al, 2003; Jian-xin et al, 2015) may persist and reflect on improved post-stroke cognition in exercised male rats. In middle-aged rats, similar to men, exercise training increases testosterone, sex-hormone binding globulin, and endothelial nitric oxide (e-NOS) (Zmuda et al, 1996; Seo et al, 2018). Therefore, the observed improvement in post-stroke cognition in exercised male rats could be due to enhanced cerebral blood flow and testosterone mediated effects.…”
Section: Discussionmentioning
confidence: 99%