Exercise training increases endothelial progenitor cells and decreases asymmetric dimethylarginine in peripheral arterial disease: A randomized controlled trial

Efeito do exercício físico nos níveis plasmático de Dimetilarginina Assimétrica (ADMA) e suas consequências na disfunção endotelial: uma revisão sistemática

“…(Wajchenberg, 2002;Giribela et al, 2011). (Tsarouhas et al, 2011;Turiel et al, 2011;Maeda et al, 2013;Lara et al, 2015) foi realizado com intensidade moderada e três pesquisas realizaram intervenções com esforço intenso (Reid et al, 2010;Thomson et al, 2012;Koichiro tanahash, 2014) e um estudo (Schlager et al, 2011) não relatou a intensidade do exercício.…”

“…Foi possível observar que cinco em estudos (Schlager et al, 2011;Tsarouhas et al, 2011;Turiel et al, 2011;Maeda et al, 2013;Koichiro tanahash, 2014) houve redução dos níveis de AD-MA após a intervenção do exercício aeróbio. Nos estudos que utilizaram o exercício de força ou misto (Reid et al, 2010;Thomson et al, 2012;Lara et al, 2015) não foi observado redução nos níveis plasmáticos de ADMA.…”

Endothelial Progenitor Cells Augment Collateralization and Hemodynamic Rescue in a Model of Chronic Cerebral Ischemia

“…Against this background, several experimental and clinical studies have reported beneficial implications of EPC to stimulate postnatal neovascularization in peripheral [6][7][8] and coronary artery disease. 9,10 However, little is known about the contribution of vasculogenesis and its main effectors-EPC-to collateral vessel formation in the cerebrovascular system.…”

Analysis of up-to-date studies investigating effects of physical rehabilitation on traditional and novel biochemical parameters in PAD patients with intermittent claudication: a review

“…Supervised treadmill training increases circulating EPC counts and produces decreases in ADMA levels, reflecting enhanced angiogenesis and improved endothelial function, which might contribute to cardiovascular risk reduction [52]. In the second work, high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), fibrinogen, soluble P-selectin, prothrombin fragment 1+2 (F1.2) and monocyte-platelet aggregates (MPA) were determined at study entry and after 3, 6 and 12 months.…”

“…Two controlled trial studies arranged by the same group of investigators explored the impact of a six--month supervised treadmill program on markers of angiogenesis and endothelial function in 40 PAD patients (first study) [52]. Serum markers of inflammation and platelet activation related to cardiovascular risk were determined in 53 PAD patients with intermittent claudication (second study) [53].…”