Exercise training-induced triglyceride lowering negatively correlates with DHEA levels in men with type 2 diabetes

Abstract

OBJECTIVE:To investigate the effect of an exercise training program on lipid pro®le in correlation with DHEA level and body weight and body composition in type 2 diabetic men. DESIGN: Longitudinal, controlled clinical intervention study with exercise training consisting of an 8 week supervised program of aerobic exercise (75% VO 2 peak, 45 min), twice a week and intermittent exercise, once a week, on a bicyle ergometer. SUBJECTS: Sixteen men (age 45.4 AE 7.2 y (mean AE s.d.), HbA1c 8.15 AE 1.7%, body mass index (BMI) 29.6 AE 4.6 kgam 2 ) were randomly divided into two groups: trained group (n 8) and control group (n 8 P`0.001), and DHEA levels (11.00 AE 3.10 vs 14.25 AE 4.10 nmolal, P`0.05) with no modi®cation in body weight. Changes in triglycerides were negatively correlated with changes in DHEA (r À0.81, P 0.03). This correlation was independent of changes in abdominal fat distribution. CONCLUSION: Training decreases abdominal fat depots, improves muscular mass and affects favourably triglyceride and DHEA levels. Changes in triglycerides and DHEA were inversely related.

Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in Type 2 diabetes mellitus

“…Eventually there were 15 eligible articles, but there were several multiple publications from the same trials [53,54,55,56,57,58,59,60]. Therefore, there were actually seven trials with appropriate VO 2max data that were included in the analysis.…”

Adipose tissue distribution and risk of metabolic disease: does thiazolidinedione-induced adipose tissue redistribution provide a clue to the answer?

“…For example, by comparing the V:S ratios measured before and after an intervention leading to improved systemic carbohydrate and lipid metabolism, it was found that the reduction in the V:S ratio after a given diet or exercise programme might range from ∼3-20% (Table 2). In one study, a 10-week physical exercise programme prescribed to type 2 diabetic patients reduced the V:S ratio by more than 33%, and this was associated with significantly decreased triacylglycerol and increased dehydroepiandrosterone levels [51] (Table 2). In contrast, another study in which metformin was used to treat patients with polycystic ovary syndrome for 12 weeks at a dosage of 500 mg three times daily, showed that the decreased total cholesterol and LDL-cholesterol levels were not accompanied by any significant change in body fat distribution [52] ( Table 2).…”

Effects of aerobic exercise on lipids and lipoproteins in adults with type 2 diabetes: A meta-analysis of randomized-controlled trials

“…6 In relation to diabetes treatment before the start of the study, one reported treatment with either diet alone, oral agents or insulin, 5 a second reported treatment with oral glucose-lowering drugs or insulin, 6 , a third reported treatment with diet, glibenclamide and metformin, 7 a fourth reported treatment with diet alone, sulphonylurea, metformin, or both, 8 a fifth reported that none of the participants were taking any type of hormone replacement therapy or pharmacologic therapy for Type 2 diabetes (oral hypoglycemic agents or insulin), 10 , a sixth reported that participants were taking oral hypoglycaemic medications but not insulin, 9 and a seventh reported that particpants continued to take their diabetic medication, if any, during the study as well as maintaining their usual diet. 4 Five studies reported that the participants had Type 2 diabetes for at least 1 year, 5-8,10 whereas another reported that participants had Type 2 diabetes for at least 3 months. 9 For cigarette smoking, one study reported that none of the particpants were cigarette smokers, 10 whereas two reported that some of the participants smoked.…”