Exercise training modulates cytokines activity in coronary heart disease patients

Goldhammer, Ehud; Tanchilevitch, A.; Maor, Irit; Beniamini, Yael; Rosenschein, Uri; Sagiv, Michael

doi:10.1016/j.ijcard.2004.08.073

Cited by 304 publications

(248 citation statements)

References 42 publications

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“…Despite previous conflicting data (10,11,16,17), we showed that exercise, per se, lowered IL-6 and hsCRP production, which is a promising finding. IL-18, another novel member of the IL-1 cytokine superfamily, is an independent predictor of cardiovascular events (4,18).…”

Section: Correlationsmentioning

confidence: 41%

Exercise Reduces Resistin and Inflammatory Cytokines in Patients With Type 2 Diabetes

et al. 2007

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Section: Correlationsmentioning

confidence: 41%

Exercise Reduces Resistin and Inflammatory Cytokines in Patients With Type 2 Diabetes

et al. 2007

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“…In the present study, the association between V O 2 max and IL-6 was independent of adiposity and physical activity. Whether exercise lowers levels of IL-6 cannot be confirmed by our cross-sectional study; however, several prospective studies of exercise training have demonstrated significant reductions in inflammatory markers (15,28,32,48,52). It has been reported that a single bout of exercise actually increases plasma levels of IL-6 and IL-1 (34), whereas repeated exercise training lowers the levels of these cytokines (49).…”

Section: Discussionmentioning

confidence: 58%

Markers of inflammation are inversely associated with V̇o_{2 max} in asymptomatic men

Kullo¹,

Khaleghi

Hensrud

2007

Journal of Applied Physiology

109

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Kullo IJ, Khaleghi M, Hensrud DD. Markers of inflammation are inversely associated with V O2 max in asymptomatic men. J Appl Physiol 102: 1374 -1379, 2007. First published December 14, 2006; doi:10.1152/japplphysiol.01028.2006.-We investigated whether markers of inflammation, including a cytokine (IL-6), acute-phase reactants [C-reactive protein (CRP) and fibrinogen], and white blood cell (WBC) count are associated with maximal O 2 consumption (V O2 max) in men without coronary heart disease (CHD). In asymptomatic men (n ϭ 172, 51 Ϯ 9.3 yr old), V O2 max was measured during a symptom-limited graded treadmill exercise test. Physical activity level was assessed by a standardized questionnaire. IL-6 and CRP were measured by immunoassays, fibrinogen by the Clauss method, and WBC count with a Coulter counter. IL-6 and CRP were logarithmically transformed to reduce skewness. Multivariable regression was used to assess whether markers of inflammation were associated with V O2 max after adjustment for age, body mass index, CHD risk factors, and lifestyle variables (physical activity level, percent body fat, and alcohol intake). V O2 max was 34.5 ml ⅐ kg Ϫ1 ⅐ min Ϫ1 (SD 6.1). Log IL-6 (r ϭ Ϫ0.38, P Ͻ 0.001), log CRP (r ϭ Ϫ0.40, P Ͻ 0.001), fibrinogen (r ϭ Ϫ0.42, P Ͻ 0.001), and WBC count (r ϭ Ϫ0.22, P ϭ 0.004) were each correlated with V O2 max. In separate multivariable linear regression models that adjusted for age, body mass index, CHD risk factors, and lifestyle variables, log IL-6 [␤-coeff ϭ Ϫ1.66 Ϯ 0.63 (SE), P ϭ 0.010], log CRP [␤-coeff ϭ Ϫ0.99 Ϯ 0.33 (SE), P ϭ 0.003], fibrinogen [␤-coeff ϭ Ϫ1.51 Ϯ 0.44 (SE), P ϭ 0.001], and WBC count [␤-coeff ϭ Ϫ0.52 Ϯ 0.30 (SE), P ϭ 0.088] were each inversely associated with V O2 max. In conclusion, higher circulating levels of IL-6, CRP, and fibrinogen are independently associated with lower V O2 max in asymptomatic men.fitness; interleukin-6; C-reactive protein; fibrinogen SEVERAL PROSPECTIVE STUDIES have shown greater cardiorespiratory fitness to be associated with a lower risk of coronary heart disease (CHD) in asymptomatic individuals (3,4,13,19,31,33). The association is independent of measures of adiposity, and a potential underlying mechanism may be that greater cardiorespiratory fitness reduces systemic inflammation (51). Atherosclerosis is recognized as a chronic inflammatory disorder, and activation of inflammatory pathways is a key event in the initiation as well as progression of atherosclerotic vascular disease (42).Prior studies have shown acute-phase reactants, such as C-reactive protein (CRP) and fibrinogen, and white blood cell (WBC) count to be inversely related to cardiorespiratory fitness (6,7,21,22,38,54). Whether more "proximal" mediators in the inflammatory cascade, such as the cytokines, are similarly associated with cardiorespiratory fitness is not known. Furthermore, previous studies of inflammation and cardiorespiratory fitness used treadmill time, rather than a direct measure of cardiorespiratory fitness, i.e., maximal O 2 consumption (V O 2 max ). ...

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“…Moreover, the enhancement of the antioxidant enzymatic capacity [63], the improvement of vasodilatation capacity of blood vessels [38] and the favourable modifications of lipoprotein blood profile [6,32] and the increment of LDL oxidation resistance [150] have also been described as favourable adaptations of diabetic patients taking part in physical exercise programmes. All these advantages may also be complemented by the improvement in the profile of inflammatory markers induced by physical exercise in diabetic patients, namely a diminution of the C-reactive protein [54,67,103], IL-1 [54], IL-6 [40, 54,67], IL-8 [93], IL-18 [67], tumour necrosis factor-α [67], interferon γ [54] and ICAM-1 [151] and an increase in IL-10 [54].…”

Section: Ages and Regular Physical Activitymentioning

confidence: 99%

Involvement of advanced glycation end products in the pathogenesis of diabetic complications: the protective role of regular physical activity

Magalhães

Appell

Duarte

2008

Eur Rev Aging Phys Act

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Exercise training modulates cytokines activity in coronary heart disease patients

Cited by 304 publications

References 42 publications

Exercise Reduces Resistin and Inflammatory Cytokines in Patients With Type 2 Diabetes

Exercise Reduces Resistin and Inflammatory Cytokines in Patients With Type 2 Diabetes

Markers of inflammation are inversely associated with V̇o_{2 max} in asymptomatic men

Involvement of advanced glycation end products in the pathogenesis of diabetic complications: the protective role of regular physical activity

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Exercise training modulates cytokines activity in coronary heart disease patients

Cited by 304 publications

References 42 publications

Exercise Reduces Resistin and Inflammatory Cytokines in Patients With Type 2 Diabetes

Exercise Reduces Resistin and Inflammatory Cytokines in Patients With Type 2 Diabetes

Markers of inflammation are inversely associated with V̇o2 max in asymptomatic men

Involvement of advanced glycation end products in the pathogenesis of diabetic complications: the protective role of regular physical activity

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Markers of inflammation are inversely associated with V̇o_{2 max} in asymptomatic men