2008
DOI: 10.2165/00007256-200838120-00005
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Exercise, Vascular Wall and Cardiovascular Diseases

Abstract: Cardiovascular disease (CVD) remains the leading cause of morbidity and premature mortality in both women and men in most industrialized countries, and has for some time also established a prominent role in developing nations. In fact, obesity, diabetes mellitus and hypertension are now commonplace even in children and youths. Regular exercise is rapidly gaining widespread advocacy as a preventative measure in schools, medical circles and in the popular media. There is overwhelming evidence garnered from a num… Show more

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Cited by 159 publications
(132 citation statements)
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“…Evidence supports the protective effect of exercise on the decrease of oxidative stress, which has a direct impact on the use of exercise practice as treatment of cardiovascular diseasesproporcionas 1,5,15 . This review tries to associate physical exercise and endothelial function, not only under normal physiological patterns, but also related to cardiovascular diseases.…”
mentioning
confidence: 87%
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“…Evidence supports the protective effect of exercise on the decrease of oxidative stress, which has a direct impact on the use of exercise practice as treatment of cardiovascular diseasesproporcionas 1,5,15 . This review tries to associate physical exercise and endothelial function, not only under normal physiological patterns, but also related to cardiovascular diseases.…”
mentioning
confidence: 87%
“…The damage to the vascular endothelium caused by risk factors such as dyslipidemia and systemic arterial hypertension causes the progressive loss of these physiological protective functions, characterizing the endothelial dysfunction 1,4,5,19,21 . Figure 1 shows this association 22 .…”
Section: Ghisi Et Al Physical Exercise and Endothelial Dysfunctionmentioning
confidence: 99%
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“…A reabilitação cardíaca através do treinamento físico está associada com a melhora da função endotelial, estresse oxidativo e inflamação 11,12 , além de promover efeitos benéficos sobre os desfechos cardiovasculares e diminuir as internações hospitalares e a mortalidade 13,14 .…”
Section: Introductionunclassified
“…Endothelium plays a role in vascular homeostasis and has many endocrine, autocrine and paracrine functions, 3 which is why it is responsible for synthesizing vasoconstrictor and vasodilator substances. 4 Intact endothelium plays a protective role in blood vessels that is triggered by physiological stimuli such as shear stress exerted by blood flow against endothelial cells, resulting in production of nitric oxide (NO), the function of which is to maintain the blood vessel in a constant state of vasodilation. 5 In contrast, endothelin-1 (ET-1) has the opposite effect to NO, with a vasoconstrictor action.…”
Section: Introductionmentioning
confidence: 99%