Exhaled ERCC-1 and ERCC-2 microsatellite alterations in NSCLC patients

Carpagnano, Giovanna Elisiana; Palladino, Grazia Pia; Gramiccioni, Claudia; Barbaro, Maria Pia Foschino; Martinelli, Domenico

doi:10.1016/j.lungcan.2010.01.020

Cited by 20 publications

(15 citation statements)

References 8 publications

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“…ERCC1 and ERCC2 genes are known to be associated with the resistance to platinum-based chemotherapy [38]. Thus, it is not surprising that 19q13.2-3 damage resulting in ERCC1 and ERCC2 gene deletions detected in exhaled breath condensate-DNA, are predictors of poor survival in NSCLC patients [39]. Researches with cohort of patients with lung SCC using array-based CGH identified that gain of 19q12 increased localized lymph node metastases rather than remote metastases [22].…”

Section: Bioinformatic Annotation Of Chromosome 19mentioning

confidence: 99%

Association of chromosome 19 to lung cancer genotypes and phenotypes

Wang

Zhang

Nilsson

et al. 2015

Cancer Metastasis Rev

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The Chromosome 19 Consortium, a part of the Chromosome-Centric Human Proteome Project (C-HPP, http://www.C-HPP.org ), is tasked with the understanding chromosome 19 functions at the gene and protein levels, as well as their roles in lung oncogenesis. Comparative genomic hybridization (CGH) studies revealed chromosome aberration in lung cancer subtypes, including ADC, SCC, LCC, and SCLC. The most common abnormality is 19p loss and 19q gain. Sixty-four aberrant genes identified in previous genomic studies and their encoded protein functions were further validated in the neXtProt database ( http://www.nextprot.org/ ). Among those, the loss of tumor suppressor genes STK11, MUM1, KISS1R (19p13.3), and BRG1 (19p13.13) is associated with lung oncogenesis or remote metastasis. Gene aberrations include translocation t(15, 19) (q13, p13.1) fusion oncogene BRD4-NUT, DNA repair genes (ERCC1, ERCC2, XRCC1), TGFβ1 pathway activation genes (TGFB1, LTBP4), Dyrk1B, and potential oncogenesis protector genes such as NFkB pathway inhibition genes (NFKBIB, PPP1R13L) and EGLN2. In conclusion, neXtProt is an effective resource for the validation of gene aberrations identified in genomic studies. It promises to enhance our understanding of lung cancer oncogenesis.

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Section: Bioinformatic Annotation Of Chromosome 19mentioning

confidence: 99%

Association of chromosome 19 to lung cancer genotypes and phenotypes

Wang

Zhang

Nilsson

et al. 2015

Cancer Metastasis Rev

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“…There are several non-invasive biomarkers measurable in exhaled breath condensate, such as ferritin and superoxide dismutase [130], LTB-4 and IL-8 [131], microsatellite alterations (MAs) at the long arm of chromosome 19 [132], cyclooxygenase (COX-2) and survivin [133], IL-2, TNF-alpha and leptin [134], which, if deemed feasible, have clinical implications in the monitoring of lung cancer and as an religious outcome predictor.…”

Section: Cancermentioning

confidence: 99%

Religious and Spiritual Biomarkers in Both Health and Disease

Kharitonov¹

2012

Religions

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Religious thought and spirituality can be considered as a part of natural human capacities. There is an exponential rise in clinical research in the relationship between religion, spirituality and positive health outcomes. Most of these studies, however, have been primarily descriptive, rather than explanatory, focusing on identifying their underlying mechanisms. Almost no attempts have been made to find novel methods to mirror and monitor positive, and possibly negative, reactions related to the local and general effects of religion and spirituality in healthy subjects and patients. As this area of interest is rather new, we propose to put forward a new hypothesis that effects of religion and spirituality can be objectively studied by various exhaled biomarkers, some of which have already been developed and tested in health and disease. The lungs are particularly well suited for this purpose, as we have easy access to exhaled air and thereby a possibility to develop methods that measure compounds directly released from them. This work is the first step in the convergence of medical and theological research by linking various biomarkers and physiological measures with indicators of individual belief systems, religiosity and spirituality.

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“…Numerous genetic alterations have been recognised as critical effects of cigarette smoke and studied in the airways of current and former smokers. Microsatellite alterations (MAs) at 3p and 19q are among the most studied, being considered useful markers of genetic susceptibility and genome destabilisation in susceptible smokers [2,3]. Instability and/or loss of heterozygosity at 3p and 19q have largely been reported in the lung tissue, sputum and blood of smokers and lung tumour patients [2,4].…”

Section: To the Editorsmentioning

confidence: 99%

“…Instability and/or loss of heterozygosity at 3p and 19q have largely been reported in the lung tissue, sputum and blood of smokers and lung tumour patients [2,4]. These mutations, which are considered an early effect of cigarette smoke, are dose-dependent and related to the number of cigarettes smoked in a lifetime [3]. In addition, short-term exposure to cigarette smoke seems to cause MAs at 3p that are not necessarily a consequence of the development of a neoplastic mass [5].…”

Section: To the Editorsmentioning

confidence: 99%