Existe-t-il un risque particulier lié aux infections à papillomavirus chez les femmes lupiques ?

Berthier, S.; Mougin, Christiane; Vercherin, Paul; Desmurs, H; Gil, H.; Wazières, B. de; Dupond, J.L.

doi:10.1016/s0248-8663(99)83029-x

Cited by 18 publications

(7 citation statements)

References 29 publications

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“…A study from of 85 SLE patients from China revealed intermediate- or high-risk HPV genotype infection in 10.6% of SLE patients versus 4.2% in controls (9). In a French study consisted of 11 women with SLE, HPV-positivity was observed in 37.5% of the patients compared to 14.7% of the controls (13). We observed that 24.6% of the 134 Korean SLE patients were infected with high-risk HPV.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Human Papilloma Virus Infections and Cervical Cytological Abnormalities among Korean Women with Systemic Lupus Erythematosus

et al. 2010

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We performed a multicenter cross-sectional study of 134 sexually active systemic lupus erythematosus (SLE) patients to investigate the prevalence of and risk factors for high risk human papilloma virus (HPV) infection and cervical cytological abnormalities among Korean women with SLE. In this multicenter cross-sectional study, HPV testing and routine cervical cytologic examination was performed. HPV was typed using a hybrid method or the polymerase chain reaction. Data on 4,595 healthy women were used for comparison. SLE patients had greater prevalence of high-risk HPV infection (24.6% vs. 7.9%, P<0.001, odds ratio 3.8, 95% confidence interval 2.5-5.7) and of abnormal cervical cytology (16.4 vs. 2.8%, P<0.001, OR 4.4, 95% CI 2.5-7.8) compared with controls. SLE itself was identified as independent risk factors for high risk HPV infection among Korean women (OR 3.8, 95% CI 2.5-5.7) along with ≥2 sexual partners (OR 8.5, 95% CI 1.2-61.6), and Pap smear abnormalities (OR 97.3, 95% CI 6.5-1,456.7). High-risk HPV infection and cervical cytological abnormalities were more common among Korean women with SLE than controls. SLE itself may be a risk factor for HPV infection among Korean women, suggesting the importance of close monitoring of HPV infections and abnormal Pap smears in SLE patients.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Human Papilloma Virus Infections and Cervical Cytological Abnormalities among Korean Women with Systemic Lupus Erythematosus

et al. 2010

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“…An increased rate of HPV infection could also be responsible for the increased frequency of cervical dysplasia in women with SLE. In women with normal Pap smears, patients with SLE are more likely than healthy subjects to have an HPV infection [95]. Additionally, patients with SLE are more likely to develop infections with multiple HPV strains as well as infections with high-risk HPV subtypes [96].…”

Section: Factors Potentially Mediating Riskmentioning

confidence: 99%

A review on SLE and malignancy

Choi

Flood

Bernatsky

et al. 2017

Best Practice & Research Clinical Rheumatology

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Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease characterized by autoantibody production, complement activation, and immune complex deposition. It predominantly affects young and middle-aged women. While improvements in the diagnosis and treatment of SLE have altered prognosis, morbidity and mortality rates remain higher than the general population. In addition to renal injury, cardiovascular disease, and infection, malignancy is known to be a significant cause of death in this population. There is increasing evidence to suggest that patients with SLE have a slightly higher overall risk of malignancy. The risk of malignancy in SLE is of considerable interest because the immune and genetic pathways underlying the pathogenesis of SLE and the immunosuppressant drugs (ISDs) used in its management may mediate this altered risk. Our current understanding of these and other risk factors and the implications for treating SLE and screening for malignancy is still evolving. This review summarizes the association between SLE and malignancy. The first section discusses the risk of overall and site-specific malignancies in both adult- and pediatric-onset SLE. Next, we evaluate the risk factors and possible mechanisms underlying the link between malignancy and SLE, including the use of ISDs, presence of certain SLE-related autoantibodies, chronic immune dysregulation, environmental factors, and shared genetic susceptibility. Finally, we review guidelines regarding cancer screening and vaccination for human papilloma virus.

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“…Mycophenolate mofetil was shown to reduce the number of B cells and natural killer cells in SLE patients, thus enhancing the risk of an HPV infection [ 9 ]. Interestingly, the use of immunosuppressive drugs was not always associated with a higher prevalence of HPV infection, probably because of an inadequate number of cases analyzed or controls [ 2 , 3 , 12 , 13 ]. In the study of Klumb et al [ 2 ], SLE patients with mild or no immunosuppressant use were more often diagnosed with an HPV infection, although the difference was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Multiple HPV-Induced Squamous Cell Carcinomas on the Fingers of a Patient with Systemic Lupus Erythematosus: A Case and Review

et al. 2015

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Human papilloma virus (HPV) infection is documented to be involved in the development of epithelial malignancies, mostly in cervical cancer. Systemic lupus erythematosus (SLE) patients have an increased prevalence of such an infection. We report the case of a 55-year-old female SLE patient who developed multiple in situ squamous cell carcinomas on her fingers, after chronic HPV infection. HPV-33 DNA was isolated from the lesions. The purpose of this case presentation is to raise awareness about HPV-induced malignancies for this high-risk group and propose an early HPV vaccination to efficiently prevent such comorbidities.

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Existe-t-il un risque particulier lié aux infections à papillomavirus chez les femmes lupiques ?

Cited by 18 publications

References 29 publications

Prevalence of Human Papilloma Virus Infections and Cervical Cytological Abnormalities among Korean Women with Systemic Lupus Erythematosus

Prevalence of Human Papilloma Virus Infections and Cervical Cytological Abnormalities among Korean Women with Systemic Lupus Erythematosus

A review on SLE and malignancy

Multiple HPV-Induced Squamous Cell Carcinomas on the Fingers of a Patient with Systemic Lupus Erythematosus: A Case and Review

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