In this article we study the problemwhere 2 := ( ) is the biharmonic operator, a, b > 0 are constants, N ≤ 7, p ∈ (4, 2 * ) for 2 * defined below, and V (x) ∈ C(R N , R). Under appropriate assumptions on V (x), the existence of least energy sign-changing solution is obtained by combining the variational methods and the Nehari method.