Existence, Functional Impairment And Therapeutic Potential Of Endothelial Colony Forming Cells (ECFCs) In Oxygen-Induced Arrested Alveolar Growth

Alphonse, Rajesh S.; Vadivel, Arul; Waszak, Paul; Fung, Moses; Coltan, Lavinia; Eaton, Farah; Yöder, Mervin C.; Thébaud, Bernard

doi:10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1237

Cited by 4 publications

(3 citation statements)

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“…Recently several studies In various animal models of BPD have demonstrated that intravenous or intratracheal delivery of bone marrow-derived MSCs (BMSCs) was capable of regenerating lung vascular and alveolar growth and reversing associated pulmonary hypertension [ 90 ]. The same effects in BPD models have been obtained with human UCB-derived EPCs [ 91 ]. However, a very important acquisition emerging from stem cells studies is that, rather than cells replacement, the beneficial therapeutic effect of BM and UCB-derived MSCs or EPCs can be mediated through a paracrine mechanism [ 92 ].…”

Section: Introductionsupporting

confidence: 52%

Molecular physiopathogenetic mechanisms and development of new potential therapeutic strategies in persistent pulmonary hypertension of the newborn

Distefano

Sciacca

2015

Ital J Pediatr

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Persistent pulmonary hypertension of the newborn (PPHN) is a cyanogenic plurifactorial disorder characterized by failed postnatal drop of pulmonary vascular resistance and maintenance of right-to-left shunt across ductus arteriosus and foramen ovale typical of intrauterine life. The pathogenesis of PPHN is very complex and can result from functional (vasoconstriction) or structural (arteriolar remodeling, reduced pulmonary vessels density) anomalies of pulmonary circulation. Etiopathogenetic factors heterogeneity can strongly condition therapeutical results and prognosis of PPHN that is particularly severe in organic forms that are usually refractory to selective pulmonary vasodilator therapy with inhaled nitric oxide. This paper reports the more recent acquisitions on molecular physiopathogenetic mechanisms underlying functional and structural forms of PPHN and illustrates the bases for adoption of new potential treatment strategies for organic PPHN. These strategies aim to reverse pulmonary vascular remodeling in PPHN with arteriolar smooth muscle hypertrophy and stimulate pulmonary vascular and alveolar growth in PPHN associated with lung hypoplasia.In order to restore lung growth in this severe form of PPHN, attention is focused on the results of studies of mesenchymal stem cells and their therapeutical paracrine effects on bronchopulmonry dysplasia, a chronic neonatal lung disease characterized by arrested vascular and alveolar growth and development of pulmonary hypertension.

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Section: Introductionsupporting

confidence: 52%

Molecular physiopathogenetic mechanisms and development of new potential therapeutic strategies in persistent pulmonary hypertension of the newborn

Distefano

Sciacca

2015

Ital J Pediatr

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“…Aside from these circulating ECFCs, the lung also harbors its own resident population of ECFCs, resident microvascular endothelial progenitor cells, that express the progenitor marker CD34 and give rise to large colonies in vitro (Alvarez et al, ; Schniedermann et al, ). Moreover, Alphonse et al found that lung endogenous ECFCs isolated from rat pups after exposure to hyperoxia exhibit decreased proliferative, clonogenic, and in vitro vessel‐forming potential, while exogenous human cord‐derived ECFCs were able to promote lung repair in this model (Alphonse et al, ). Because pulmonary capillary endothelial cells can support the expansion of epithelial cells and subsequently alveolar development through angiocrine signaling (Ding et al, ), an impairment of the lung endogenous ECFC population may be directly linked to both the simplified alveolar and microvascular development in BPD.…”

Section: Endothelial and Other Progenitors Of The Distal Lungmentioning

confidence: 99%

Progenitor cells of the distal lung and their potential role in neonatal lung disease

Collins

Thébaud

2014

Birth Defects Research

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Bronchopulmonary dysplasia (BPD) is the most common adverse outcome in extreme preterm neonates (born before 28 weeks gestation). BPD is characterized by interrupted lung growth and may predispose to early-onset emphysema and poor lung function in later life. At present, there is no treatment for BPD. Recent advances in stem/progenitor cell biology have enabled the exploration of endogenous lung progenitor populations in health and disease. In parallel, exogenous stem/progenitor cell administration has shown promise in protecting the lung from injury in the experimental setting. This review will provide an outline of the progenitor populations that have currently been identified in all tissue compartments of the distal lung and how they may be affected in BPD. A thorough understanding of the lung's endogenous progenitor populations during normal development, injury and repair may one day allow us to harness their regenerative capacity.

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“…It has been demonstrated that both circulating and resident lung EPCs are likely to contribute to endothelial cell regeneration and repair in the lung. 49,50 The recent surge in our knowledge of stem cell biology and the availability of advanced research tools in this field has motivated researchers in exploring the role of lung stem cells in the pathogenesis of lung diseases. Indeed, several major lung diseases likely involve dysregulation in the numbers and/or the function of resident lung stem/progenitor cells.…”

Section: Lung Mesenchymal Stem Cellsmentioning

confidence: 99%

Cell-Based Strategies to Reconstitute Lung Function in Infants with Severe Bronchopulmonary Dysplasia

O’Reilly

Thébaud

2012

Clinics in Perinatology

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Recent advances in our understanding of stem/progenitor cells and their potential to repair damaged organs offer the possibility of cell-based treatments for neonatal lung injury. This review summarizes basic concepts of stem/progenitor cell biology and discusses the recent advances and challenges of cell-based therapies for lung diseases, with a particular focus on bronchopulmonary dysplasia (BPD), a form of chronic lung disease that primarily affects very preterm infants. Despite advances in perinatal care, BPD still remains the most common complication of extreme prematurity, and there is no specific treatment.

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Existence, Functional Impairment And Therapeutic Potential Of Endothelial Colony Forming Cells (ECFCs) In Oxygen-Induced Arrested Alveolar Growth

Cited by 4 publications

References 0 publications

Molecular physiopathogenetic mechanisms and development of new potential therapeutic strategies in persistent pulmonary hypertension of the newborn

Molecular physiopathogenetic mechanisms and development of new potential therapeutic strategies in persistent pulmonary hypertension of the newborn

Progenitor cells of the distal lung and their potential role in neonatal lung disease

Cell-Based Strategies to Reconstitute Lung Function in Infants with Severe Bronchopulmonary Dysplasia

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