In this paper, we study a nonlinear interaction problem between compressible viscous fluids and plates. For this problem, we introduce relative entropy and relative energy inequality for the finite energy weak solutions (FEWS). First, we prove that for all FEWS, the relative energy inequality is satisfied and that the structure displacement enjoys improved regularity by utilizing the dissipation effects of the fluid onto the structure. Then, we show that all FEWS enjoy the weak-strong uniqueness property, thus extending the classical result for compressible Navier-Stokes system to this fluidstructure interaction problem.