We studied a class of generalized n-species non-autonomous cooperative Lotka–Volterra (L-V) systems with time delays. We obtained new criteria on the dynamic properties of the systems. First, we obtained the boundedness and permanence of the system using the inequality analysis technique and comparison method. Then, the existence of positive periodic solutions was investigated using the coincidence degree theory. The global attractivity of the system was obtained by constructing suitable Lyapunov functionals and utilizing Barbalat’s lemma. The existence and global attractivity of the periodic solutions were also obtained. Finally, we conducted two numerical simulations to validate the feasibility and practicability of our results.