Exogenous Hydrogen Sulfide Plays an Important Role Through Regulating Autophagy in Ischemia/Reperfusion Injury

Lv, Shuangyu; Wang, Zhu; Wang, Jie; Wang, Honggang

doi:10.3389/fmolb.2021.681676

Cited by 14 publications

(10 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We previously reported increased CGL expression correlates with increased endogenous H 2 S production capacity and is required for DR-mediated protection from hepatic ischemia reperfusion injury (IRI) [ 30 ], the growth of blood vessels in skeletal muscle [ 28 ], maintaining proper IGF-1 and thyroid hormonal response to fasting [ 37 ], protection against vein graft disease [ 12 ], and expanding tissue-specific protein persulfidomes [ 38 ]. Exogenous H 2 S not only protects against multi-tissue IRI [ 39 , 40 , 41 , 42 ], but protects against radiation-induced myelosuppression [ 43 ] and cell death [ 44 ]. We thus examined the requirement for sulfur amino acid metabolism via the transsulfuration pathway enzyme CGL, along with H 2 S itself, in DR-mediated radioprotection in BM and hematopoietic systems.…”

Section: Resultsmentioning

confidence: 99%

Sulfur Amino Acid Supplementation Abrogates Protective Effects of Caloric Restriction for Enhancing Bone Marrow Regrowth Following Ionizing Radiation

et al. 2022

View full text Add to dashboard Cite

Radiation therapy damages and depletes total bone marrow (BM) cellularity, compromising safety and limiting effective dosing. Aging also strains total BM and BM hematopoietic stem and progenitor cell (HSPC) renewal and function, resulting in multi-system defects. Interventions that preserve BM and BM HSPC homeostasis thus have potential clinical significance. Here, we report that 50% calorie restriction (CR) for 7-days or fasting for 3-days prior to irradiation improved mouse BM regrowth in the days and weeks post irradiation. Specifically, one week of 50% CR ameliorated loss of total BM cellularity post irradiation compared to ad libitum-fed controls. CR-mediated BM protection was abrogated by dietary sulfur amino acid (i.e., cysteine, methionine) supplementation or pharmacological inhibition of sulfur amino acid metabolizing and hydrogen sulfide (H2S) producing enzymes. Up to 2-fold increased proliferative capacity of ex vivo-irradiated BM isolated from food restricted mice relative to control mice indicates cell autonomy of the protective effect. Pretreatment with H2S in vitro was sufficient to preserve proliferative capacity by over 50% compared to non-treated cells in ex vivo-irradiated BM and BM HSPCs. The exogenous addition of H2S inhibited Ten eleven translocation 2 (TET2) activity in vitro, thus providing a potential mechanism of action. Short-term CR or fasting therefore offers BM radioprotection and promotes regrowth in part via altered sulfur amino acid metabolism and H2S generation, with translational implications for radiation treatment and aging.

show abstract

Section: Resultsmentioning

confidence: 99%

Sulfur Amino Acid Supplementation Abrogates Protective Effects of Caloric Restriction for Enhancing Bone Marrow Regrowth Following Ionizing Radiation

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Mitochondrial BNIP3 binds to autophagosome LC3 to regulate cell death in ischemic stroke [36][37][38]. Mitochondrial dysfunction during ischemic stroke affects the level of autophagy, involving metabolic imbalance, oxidative stress, apoptosis, endoplasmic reticulum stress, and many other aspects, which may provide inspiration for the development of new targeted therapies for ischemic stroke [39][40][41][42][43][44][45]. Cellular responses to ischemic stroke are represented by autophagy, which is an adaptive mechanism [46].…”

Section: Related Workmentioning

confidence: 99%

A Bibliometric Analysis for Global Trends and Full View of the Autophagy in Ischemic Stroke from 2006 to 2022

Song

Yuan

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

Autophagy plays a key role in ischemic stroke, but its mechanism remains to be elucidated. In order to explore the effect of autophagy on ischemic stroke, bibliometric analysis and view tools are used to identify the directions of the global research trends and construct full view of the autophagy in ischemic stroke from 2006 to 2022. The research hotspots of autophagy related to ischemic stroke are visually analyzed and generated various visual maps to display publications, authors, sources, countries, organizations, and keywords. By bibliometric analysis, it can be seen that the investigations of autophagy in ischemic stroke is focused on both brain injury and neuroprotection. The impact of a variety of inflammatory factors and signaling pathways on autophagy following an ischemic stroke is also studied. Autophagy plays an important role in all phases of ischemic stroke. It is of great significance to guide the development of treatment plans for ischemic stroke.

show abstract

“…In recent years, more and more evidence demonstrates that dysfunctional autophagy is related with many diseases, including ischemia/reperfusion injury. However, the related mechanisms are not fully clear [ 35 , 36 , 37 ].…”

Section: Overview Of Autophagymentioning

confidence: 99%

The Role of Pyroptosis and Autophagy in Ischemia Reperfusion Injury

Zhao

Yang

et al. 2022

Biomolecules

Self Cite

View full text Add to dashboard Cite

Pyroptosis is a process of programmed cell death mediated by gasdermin (GSDM) found in recent years. In the process of pyroptosis, caspase-1 or caspase-11/4/5 is activated, which cleaves gasdermin D and separates its N-terminal pore-forming domain (PFD). The oligomers of PFD bind to the cell membrane and form macropores on the membrane, resulting in cell swelling and membrane rupture. Increasing evidence indicates that pyroptosis is involved in many diseases, including ischemia reperfusion injury. Autophagy is a highly conserved catabolic process in eukaryotic cells. It plays an important role in the survival and maintenance of cells by degrading organelles, proteins, and macromolecules in the cytoplasm and recycling degradation products. Increasing evidence shows that dysfunctional autophagy participates in many diseases. Recently, autophagy and pyroptosis have been reported to play a vital role in the process of ischemia/reperfusion injury, but the related mechanisms are not completely clear. Therefore, this article reviews the role of autophagy and pyroptosis in ischemia–reperfusion injury and analyzes the related mechanisms to provide a basis for future research.

show abstract

Exogenous Hydrogen Sulfide Plays an Important Role Through Regulating Autophagy in Ischemia/Reperfusion Injury

Cited by 14 publications

References 63 publications

Sulfur Amino Acid Supplementation Abrogates Protective Effects of Caloric Restriction for Enhancing Bone Marrow Regrowth Following Ionizing Radiation

Sulfur Amino Acid Supplementation Abrogates Protective Effects of Caloric Restriction for Enhancing Bone Marrow Regrowth Following Ionizing Radiation

A Bibliometric Analysis for Global Trends and Full View of the Autophagy in Ischemic Stroke from 2006 to 2022

The Role of Pyroptosis and Autophagy in Ischemia Reperfusion Injury

Contact Info

Product

Resources

About