2016
DOI: 10.4103/1793-5482.145375
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Exogenous lactate infusion improved neurocognitive function of patients with mild traumatic brain injury

Abstract: Background:Many studies showed a better recovery of cognitive function after administration of exogenous lactate during moderate-severe traumatic brain injury. However, the study evaluating lactate effect on mild traumatic brain injury is still limited.Aims:To evaluate the effect of exogenous lactate on cognitive function in mild traumatic brain injury patients.Settings and Design:Prospective, single blind, randomized controlled study on 60 mild traumatic brain injury patients who were undergoing neurosurgery.… Show more

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Cited by 33 publications
(28 citation statements)
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“…In addition, exogenous administration of lactate reduced brain lesion size in a rat controlled cortical impact models of TBI (Alessandri et al, 2012) and in patients with severe TBI (Bouzat et al, 2014). Similarly, lactate infusion prevented intracranial hypertensive episodes in patients with severe TBI (Ichai et al, 2009, 2013; Bouzat et al, 2014), and attenuated cognitive deficits in rat lateral fluid percussion injury (Rice et al, 2002; Holloway et al, 2007) and in patients with mild TBI (Bisri et al, 2016). …”
Section: Metabolic Treatments In Alsmentioning
confidence: 97%
“…In addition, exogenous administration of lactate reduced brain lesion size in a rat controlled cortical impact models of TBI (Alessandri et al, 2012) and in patients with severe TBI (Bouzat et al, 2014). Similarly, lactate infusion prevented intracranial hypertensive episodes in patients with severe TBI (Ichai et al, 2009, 2013; Bouzat et al, 2014), and attenuated cognitive deficits in rat lateral fluid percussion injury (Rice et al, 2002; Holloway et al, 2007) and in patients with mild TBI (Bisri et al, 2016). …”
Section: Metabolic Treatments In Alsmentioning
confidence: 97%
“…On the contrary, the continuously increased serum lactate level during exogenous infusion of hypertonic sodium lactate could indicate better survival and recovery after TBI [30,38,39]. Because increased serum lactate during exogenous supplement is not a re ection of initial tissue hypoperfusion and organ failure, but only means more alternative energy fuel for injured brain.…”
Section: Discussionmentioning
confidence: 99%
“…Eventually, the edematous fluid will be drawn into the blood vessel and greatly contribute to lowering ICP. [ 37 38 ]…”
Section: The Usage Of Hypertonic Sodium Lactate In Traumatic Brain Inmentioning
confidence: 99%
“…HSL contains inorganic cation (Na+, K+, and Ca2 + ) and organic anion of lactate, while HTS 3% has inorganic cation and anion of sodium and chloride. [ 37 ] Several researches have been proven that HSL significantly reduces ICP and maintain mean arterial pressure (MAP) remained in the figures recommended by the Brain Trauma Foundation. [ 38 ] In addition, HSL also has the additional effect in the improvement of cognitive function after TBI.…”
Section: The Usage Of Hypertonic Sodium Lactate In Traumatic Brain Inmentioning
confidence: 99%
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