Exogenous testosterone treatment decreases diaphragm neuromuscular transmission failure in male rats

Blanco, Cesar E.; Zhan, Wen Zhi; Fang, Yun; Sieck, Gary C.

doi:10.1152/jappl.2001.90.3.850

Cited by 23 publications

(15 citation statements)

References 43 publications

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“…None of the TOE methods tested provided an acceptable approximation to a previously validated reference technique [2,3]. As expected with the exogenous use of testosterone, the patient was suffering primary hypogonadism from negative feedback inhibition of the pituitary gland.…”

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confidence: 86%

“…As expected with the exogenous use of testosterone, the patient was suffering primary hypogonadism from negative feedback inhibition of the pituitary gland. There is an emphasis on the patient's hypogonadism contributing to his demise despite the fact that hypogonadism is not an uncommon finding in elderly males, with a significant number of these hypogonadal elderly males undergoing aortic valve replacement without difficulty [2,3]. Cardiac arrhythmia was also implicated as a possible contributing factor in this case and was thought to be secondary to myocyte toxicity and fibrosis from anabolic steroid use.…”

mentioning

confidence: 89%

“…Although we realise that such a rapid improvement of respiratory function is . ..................................................................................................................................................................................................................... Ó 2005 Blackwell Publishing Ltd not easy to explain, there is experimental data suggesting that testosterone can influence neuromuscular transmission in the diaphragm of rats [2,3]. Furthermore, it was seen after shorter rather than longer periods of treatment (2.5 weeks vs. 10 weeks) [4].…”

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confidence: 99%

“…Of the various methods to simulate a restricted view of the vocal cords in a manikin such as the use of a cervical collar, in-line immobilisation of head and neck, or limited traction on the laryngoscope, the authors chose limited traction on a laryngoscope. However, the use of such methodology, so far removed from clinical practice, to evaluate devices and procedures advocated for difficult laryngoscopy, is questionable [2].…”

Section: A Replymentioning

confidence: 99%

“…It seems much more plausible that the respiratory failure was due to a complication of the aortic valve surgery and subsequent upper respiratory infection. Respiratory failure is a known complication of aortic valve replacement [2]. The patient evidently had a period of increased respiratory drive after injections with testosterone.…”

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The postoperative catabolic state: when do you intervene?

Dickerman¹,

Morgan²,

McConathy³

et al. 2005

Anaesthesia

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confidence: 89%

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confidence: 99%

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confidence: 99%

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The postoperative catabolic state: when do you intervene?

Dickerman¹,

Morgan²,

McConathy³

et al. 2005

Anaesthesia

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Structure and Function of the Mammalian Neuromuscular Junction

Davis

Fogarty

Brown

et al. 2022

Comprehensive Physiology

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The mammalian neuromuscular junction (NMJ) comprises a presynaptic terminal, a postsynaptic receptor region on the muscle fiber (endplate), and the perisynaptic (terminal) Schwann cell. As with any synapse, the purpose of the NMJ is to transmit signals from the nervous system to muscle fibers. This neural control of muscle fibers is organized as motor units, which display distinct structural and functional phenotypes including differences in pre-and postsynaptic elements of NMJs. Motor units vary considerably in the frequency of their activation (both motor neuron discharge rate and duration/duty cycle), force generation, and susceptibility to fatigue. For earlier and more frequently recruited motor units, the structure and function of the activated NMJs must have high fidelity to ensure consistent activation and continued contractile response to sustain vital motor behaviors (e.g., breathing and postural balance). Similarly, for higher force less frequent behaviors (e.g., coughing and jumping), the structure and function of recruited NMJs must ensure short-term reliable activation but not activation sustained for a prolonged period in which fatigue may occur. The NMJ is highly plastic, changing structurally and functionally throughout the life span from embryonic development to old age. The NMJ also changes under pathological conditions including acute and chronic disease. Such neuroplasticity often varies across motor unit types.

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Hormone Use and Abuse by Athletes

Ghigo¹,

Lanfranco²,

Strasburger³

2011

Endocrine Updates

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), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein.Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) v Physical activity exerts an important influence on the endocrine system, modulating synthesis and secretion of several hormones. Almost every organ and system in the body is affected by physical activity and exercise, mainly through the endocrine and neuroendocrine system. Mode, intensity, and duration of the exercise bout, age, gender, and fitness level of the individual as well as environmental and psychological factors may affect the endocrine response to physical activity.On the other hand, several hormones are able to influence physical performance and body composition. Thus, a biunivocal interrelationship between exercise and hormones exists.In this book, new developments on metabolic and endocrine response to exercise are revised and the "hot topic" of hormonal doping in sports is introduced. In the past decades, hormone abuse has become a widespread habit among professional and -most of all and more frequently -recreational athletes. A substantial part of this volume is devoted to the effects of exogenous hormones on performance. Anabolic steroids, growth hormone and erythropoietin properties, use and misuse in sports are widely described. Specific methods to detect hormone abuse are presented and discussed.The contributors to this volume are well-known experts and dedicated researchers in the fields of sports medicine and endocrinology, endocrine physiology, pharmacology, and doping detection.The purpose of this volume is to provide all professionals involved in sports medicine and endocrinology a state-of-the-art overview of the complex interactions between physical activity and the endocrine system and to focus on hormone abuse in sports at competitive and recreational level highlighting its negative consequences for long-term health.

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Exogenous testosterone treatment decreases diaphragm neuromuscular transmission failure in male rats

Cited by 23 publications

References 43 publications

The postoperative catabolic state: when do you intervene?

The postoperative catabolic state: when do you intervene?

Structure and Function of the Mammalian Neuromuscular Junction

Hormone Use and Abuse by Athletes

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